Results 61 to 70 of about 113,223 (329)

Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by destruction of the myelin sheath structure.
Rongzeng Liu, Shushu Du, Lili Zhao, Sahil Jain, Kritika Sahay, Albert Rizvanov, Vera Lezhnyova, Timur Khaibullin, Ekaterina Martynova, Svetlana Khaiboullina, Manoj Baranwal   +10 more
doaj   +1 more source

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall, A Cruz, A Glatman-Freedman, AM Cooper, AR Martineau, B Nandi, C Diveu, C Keller, CE Sutton, CG Feng, Christopher M. Sassetti, CJ Thalhofer, CY Hu, D Kitamura, DB Rawool, DJ Cua, DV Jovanovic, E Lockhart, E Marino, E Roy, E Torrado, EB Eruslanov, FE Lund, FL Ribeiro-Gomes, J Hinchey, J Pedrosa, Jiayong Xu, JL Flynn, JM Daley, Joanne L. Flynn, John Chan, JS Thorson, JU Igietseme, K Dunussi-Joannopoulos, K Hamel, KA Sweeney, Kyri Dunussi-Joannopoulos, L Desvignes, L Li, Lee Kozakiewicz, LJ Brady, M Cella, M Laan, M Zhang, MC Tsai, ML Michel, NK Damle, P Miossec, P Seiler, P Ye, PJ Maglione, PJ Maglione, PJ Maglione, PR Hamann, PS Redford, Qinglin Ou, R Appelberg, R Blomgran, R Gopal, RJ North, SA Fulton, SA Khader, ST Passos, Steven A. Porcelli, T Eddens, T Hamilton, T Korn, T Matsushita, TK Kondratieva, W Ouyang, William R. Jacobs, X Zhang, Y Ito, Yanhua Wang, Yong Chen   +74 more
core   +3 more sources

Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance [PDF]

Haematologica, 2011
The levels and clinical relevance of Th17 cells and other interleukin-17-producing cells have not been analyzed in chronic lymphocytic leukemia. The objective of this study was to quantify blood and tissue levels of Th17 and other interleukin-17-producing cells in patients with this disease and correlate blood levels with clinical outcome.Intracellular
Jain, Preetesh, Javdan, Mohammad, Feger, Franziska K., Chiu, Pui Yan, Sison, Cristina, Damle, Rajendra N., Bhuiya, Tawfiqul A., Sen, Filiz, Abruzzo, Lynne V., Burger, Jan A., Rosenwald, Andreas, Allen, Steven L., Kolitz, Jonathan E., Rai, Kanti R., Chiorazzi, Nicholas, Sherry, Barbara   +15 more
openaire   +3 more sources

Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New

Clinical and Developmental Immunology, 2012
Pathogenic mechanisms underlying the development of systemic lupus erythematosus (SLE) are very complex and not yet entirely clarified. However, the pivotal role of T lymphocytes in the induction and perpetuation of aberrant immune response is well ...
Alessia Alunno, Elena Bartoloni, Onelia Bistoni, Giuseppe Nocentini, Simona Ronchetti, Sara Caterbi, Valentina Valentini, Carlo Riccardi, Roberto Gerli   +8 more
doaj   +1 more source

Differentiation of Th subsets inhibited by nonstructural proteins of respiratory syncytial virus is mediated by ubiquitination. [PDF]

PLoS ONE, 2014
Human respiratory syncytial virus (RSV), a major cause of severe respiratory diseases, constitutes an important risk factor for the development of subsequent asthma. However, the mechanism underlying RSV-induced asthma is poorly understood.
Ling Qin, Dan Peng, Chengping Hu, Yang Xiang, Yigang Zhou, Yurong Tan, Xiaoqun Qin   +6 more
doaj   +1 more source

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function. [PDF]

, 2019
Objective: We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of transcription-3 (STAT3) in early rheumatoid arthritis (RA).
Aletaha, Alonzi, Anderson, Anderson, Arnett, Atsumi, Bettelli, Charlot-Rabiega, Chen, Choy, Dienz, Filer, Genovese, Heinrich, Hidalgo, Hunter, Isomaki, Jones, Karlson, Kokkonen, Kremer Joel, Kuuliala, Lawson, Liu, Manel, Ohshima, Pratt, Purvis, Purvis, Ridgley, Rincón, Sallusto, Smolen, Unutmaz   +33 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

Nature Communications, 2017
Spondyloarthritis is an inflammatory disease with Th17 cells implicated in the pathogenesis. Here the authors show that patients with spondyloarthritis have increased numbers of GM-CSF-secreting blood and synovial lymphocytes, Th17 or not, that carry a ...
M. H. Al-Mossawi, L. Chen, H. Fang, A. Ridley, J. de Wit, N. Yager, A. Hammitzsch, I. Pulyakhina, B. P. Fairfax, D. Simone, Yao Yi, S. Bandyopadhyay, K. Doig, R Gundle, B. Kendrick, F. Powrie, J. C. Knight, P. Bowness   +17 more
doaj   +1 more source

Red Wine Extract Disrupts Th17 Lymphocyte Differentiation in a Colorectal Cancer Context [PDF]

Molecular Nutrition & Food Research, 2020
ScopeScope: It is well established that immune response and inflammation promote tumoral progression. Immune cells communicate through direct contact or through cytokine secretion, and it is the pro‐inflammatory status that will tip the balance toward tumor progression or anti‐tumor immunity.
Chalons, Pauline, Courtaut, Flavie, Limagne, Emeric, Chalmin, Fanny, Cantos-Villar, Emma, Richard, Tristan, Auger, Cyril, Chabert, Philippe, Schini- Kerth, Valérie, Ghiringhelli, François, Aires, Virginie, Delmas, Dominique   +11 more
openaire   +3 more sources