Results 111 to 120 of about 198,196 (300)

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

The IFN-γ production from IL-18 and/or IL-12 stimulated Th1 cells from TRAM-deficient mice and MyD88 deficient mice.

, 2012
The IFN-γ production levels were significantly reduced in TRAM deficient mice and MyD88 deficient mice. The black bars show the production levels from IL-18 and IL-12 co-stimulated Th1 cells, grey bars show those from IL-18 solely stimulated Th1 cells ...
Hidehito Tochio (16608), Norio Kawamoto (159575), Takahiro Yamamoto (159582), Tatsuyoshi Funasaka (159583), Hiroshi Nakano (159586), Hidenori Ohnishi (159568), Takeshi Kimura (159578), Naomi Kondo (159588), Zenichiro Kato (159571), Kazuo Kubota (159580), Masahiro Shirakawa (16613), Richard W. Wong (159587)   +11 more
core   +1 more source

In vivo generated Th1 cells can migrate to B cell follicles to support B cell responses [PDF]

, 2004
The description of Th1 and Th2 T cell subsets rationalized the inverse correlation between humoral and cell-mediated immunity. Although Th1 cells were described to support cell-mediated immune responses, their role in supporting certain B cell responses ...
Smith, Karen M., Rush, Catherine, Riley, Jillian, Brewer, James M., Rush, Catherine M., Garside, Paul   +5 more
core   +1 more source

Hardware‐Attentive Programmable Fourier Ptychography Enables Task‐Adaptive Label‐Free Virtual Staining

Advanced Science, EarlyView.
Task‐adaptive programmable optics enables label‐free virtual staining through optical‐attention‐guided acquisition and reconstruction. By optimizing wavelength, illumination angle, exposure time, and imaging depth, the framework learns task‐relevant optical measurements, generating clinically interpretable virtual stains with improved fidelity, non ...
Tianyue He, Wenyi Jing, Le Zhang, Qican Zhang, Tingdong Kou, Xin He, Yan Qiu, Yang Lu, Jian Cui, Yongfu Wen, Zhenrong Zheng, Hongying Zhang, Dayong Jin, Junfei Shen   +13 more
wiley   +1 more source

Treg-derived IFN-γ supports the differentiation of Th1-Treg in tumor immunity and autoimmunity

Frontiers in Immunology
Regulatory T cells (Tregs) within the tumor microenvironment (TME) exhibit functional heterogeneity, including a Foxp3+T-bet+ subset known as Th1-type Treg (Th1-Treg) cells that exert potent immunosuppressive activity.
Ayumi Kuratani, Ayumi Kuratani, Masaaki Okamoto, Sekar Arumsari, Sekar Arumsari, Takashi Kobayashi, Takashi Kobayashi, Miwa Sasai, Miwa Sasai, Miwa Sasai, Masahiro Yamamoto, Masahiro Yamamoto, Masahiro Yamamoto   +12 more
doaj   +1 more source

The Imbalance between Foxp3+Tregs and Th1/Th17/Th22 Cells in Patients with Newly Diagnosed Autoimmune Hepatitis

Journal of Immunology Research, 2018
This study is aimed at examining the potential role of regulatory T- (Treg-) Th1-Th17-Th22 cells in the pathogenic process of autoimmune hepatitis (AIH). The numbers of Foxp3+Tregs and Th1, Th17, and Th22 cells were measured in 32 AIH patients using flow
Ma Liang, Zhang Liwen, Zhuang Yun, Ding Yanbo, Chen Jianping   +4 more
doaj   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

Effects of deoxycycline induced lentivirus encoding FasL gene on apoptosis of Th1 cells

, 2013
Fas/Fas ligand (FasL)-mediated apoptosis plays a critical role in deletion of activated T cells. This study aimed to construct the lentivirus encoding FasL gene induced by deoxycycline and evaluate its effects on apoptosis of Th1 cells.
Jiang, H, Wang, J, Luo, A, Shi, Q, Luo, H, Zhao, Y, Wang, T   +6 more
core   +2 more sources

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Regulation of the differentiation and proliferation of Th1 cells by ES-DCs.

, 2014
(A) 7.0×105 naïve CD4+ T cells (CD4+ CD62L+) were purified from spleen of B6 mice and cultured for 3 days under Th1, Th17 and iTreg cell differentiation conditions as described in Material and Methods, in the presence or absence of cultured supernatant ...
Seiho Nagafuchi (450302), Shinya Hirata (676770), Hirotake Tsukamoto (503571), Makoto Uchino (227122), Koutaro Takamatsu (425941), Yasuharu Nishimura (111310), Yukio Ando (559961), Miwa Haruta (425936), Satoru Senju (425942), Tokunori Ikeda (425940), Takaaki Ito (676771)   +10 more
core   +1 more source