Results 211 to 220 of about 189,103 (261)
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Inflammatory Bowel Diseases, 1999
A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
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A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
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Crossregulation Between Th1 and Th2 Cells
Critical Reviews™ in Immunology, 1998Th1 and Th2 subsets have been characterized on the basis of the cytokines they secrete and the immune functions they mediate. Th1 cells secrete IL-2, IFN-gamma, and lymphotoxin and are important in the cell-mediated response; Th2 cells secrete IL-4, IL-5, IL-10, and IL-13 and are important in the control of macrophage function and in the stimulation of
P A, Morel, T B, Oriss
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Th1 T-CELL AND MONOCYTE DEFECTS
Pediatric Clinics of North America, 2000Mutations predisposing to infections with intracellular pathogens and affecting Th1 T-cells and monocytes have been identified in the past few years. In this article, the authors review the interaction of T cells and monocytes in the context of host defense against intracellular pathogens. Known genetic defects in these pathways are summarized.
G, Uzel, S M, Holland
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1996
Markers of TH1 and TH2 lymphocyte subpopulations.
ALMERIGOGNA, FABIO +3 more
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Markers of TH1 and TH2 lymphocyte subpopulations.
ALMERIGOGNA, FABIO +3 more
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Science Signaling, 2000
Immune responses can be mediated by cells (cell-mediated immunity) or through circulating factors like antibodies (humoral immunity), depending on whether naive T cells differentiate into T helper 1 (Th1) or T helper 2 (Th2) cells. Li et al .
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Immune responses can be mediated by cells (cell-mediated immunity) or through circulating factors like antibodies (humoral immunity), depending on whether naive T cells differentiate into T helper 1 (Th1) or T helper 2 (Th2) cells. Li et al .
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Zeitschrift fur Rheumatologie, 2012
T helper cells contribute to the induction and maintenance of rheumatic inflammation through the secretion of cytokines. The analysis of Th1 cells expressing interferon-γ, Th17 cells expressing interleukin-17 and the newly described Th1+17 cells could give insight into the pathophysiological mechanisms of rheumatic diseases.
H-D, Chang, T, Kamradt, H, Schulze-Koops
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T helper cells contribute to the induction and maintenance of rheumatic inflammation through the secretion of cytokines. The analysis of Th1 cells expressing interferon-γ, Th17 cells expressing interleukin-17 and the newly described Th1+17 cells could give insight into the pathophysiological mechanisms of rheumatic diseases.
H-D, Chang, T, Kamradt, H, Schulze-Koops
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T-cell subsets (Th1 versus Th2)
Annals of Allergy, Asthma & Immunology, 2000To understand the current status of knowledge in the basic field of polarized specific immune responses mediated by CD4+ T helper (Th) lymphocytes, based on their profile of cytokine production (type 1 or Th1 and type 2 or Th2).Relevant articles and publications from the medical literature, especially review articles dealing with properties, mechanisms
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[Th1 cells, Th2 cells and atopic dermatitis].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1997The immunological hallmark of atopic dermatitis (AD) is a Th1/Th2 dysbalance. The reaction to high molecular weight environmental allergens (e.g. pollen, house dust mites), production of IgE and activation of eosinophil granulocytes result from Th2 dominance. The Th2-cytokine interleukin-4 (IL-4) is necessary for IgE synthesis.
I, Böhm, R, Bauer
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Dendritic cell regulation of TH1-TH2 development
Nature Immunology, 2000Understanding the control exerted by cytokines on T helper cell subsets 1 and 2 (TH1-TH2) development has progressed to a fairly satisfying knowledge of intracellular signals and transcription factors. Less is understood about the molecular basis of TH1-TH2 development exerted by other parameters, such as how the antigen presenting cell can influence ...
Moser, Muriel, Murphy, Kevin
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CD4+ cell memory: the enigma of Th1 cells
Trends in Molecular Medicine, 2003Despite a wealth of information pertaining to functional and phenotypic attributes of memory CD4(+) cells, the mechanisms that underlie the generation and persistence of memory in this subset are largely unknown. Recent work suggests that the development of memory might be differently regulated in T-helper-1 and T-helper-2 cells, owing to differences ...
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