Results 91 to 100 of about 22,410 (257)

Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma

Advanced Science, EarlyView.
Hepatoblastoma, an aggressive childhood liver tumor, origins from malignant hepatoblast‐like cells. Single‐cell analysis reveals IGF2‐driven pathways promoting malignancy. Targeting these pathways offers promising treatments, with serum IGF2 as a potential diagnostic biomarker.
Miao Ding, Siwei Mao, Han Wu, Sijia Fang, Ni Zhen, Tianshu Chen, Jiabei Zhu, Xiaochen Tang, Xiaoyang Wang, Fenyong Sun, Guoqing Zhu, Qiuhui Pan, Ji Ma   +12 more
wiley   +1 more source

Crosstalk between ILC2s and Th2 cells varies among mouse models

Cell Reports, 2023
Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are still
Rama K. Gurram, Danping Wei, Qiao Yu, Matthew J. Butcher, Xi Chen, Kairong Cui, Gangqing Hu, Mingzhu Zheng, Xiaoliang Zhu, Jangsuk Oh, Bing Sun, Joseph F. Urban, Jr., Keji Zhao, Warren J. Leonard, Jinfang Zhu   +14 more
doaj  

RESPON Th2 PADA INFEKSI CACING USUS

Majalah Kedokteran Andalas, 2009
AbstrakPenyakit kecacingan masih merupakan masalah kesehatan di beberapa negara berkembang termasuk Indonesia. Prevalensi penyakit kecacingan ini masih cukup tinggi terutama pada kelompok masyarakat dengan higienisitas dan sanitasi yang rendah.Penyakit ...
Selfi Renita Rusjdi
doaj   +1 more source

Evidence for excessive Th2 CD4+ subset activity in vivo. [PDF]

, 1993
Elizabeth H. Field, R J Noelle, Todd Rouse, James A. Goeken, Thomas J. Waldschmidt   +4 more
openalex   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, Volume 12, Issue 18, May 15, 2025.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Off-label use of Baricitinib improves moderate and severe atopic dermatitis in China through inhibiting MAPK and PI3K/Akt/mTOR pathway via targeting JAK-STAT signaling of CD4+ cells

Frontiers in Pharmacology
As an inflammatory disease with a disrupted immune system, cytokine disorders in atopic dermatitis (AD) are closely related to the abnormal activation of JAK-STAT signal pathway.
Shuang Chen, Caihua Li, Caihua Li, Zeng Tu, Tao Cai, Xinying Zhang, Xinying Zhang, Lei Wang, Ruoyuan Tian, Ruoyuan Tian, Jinglan Huang, Jinglan Huang, Yuxuan Gong, Xiaotong Yang, Zetong Wu, Sirong He, Sirong He, Wenyan He, Dan Wang   +18 more
doaj   +1 more source

NKG2A inhibits TH2 cell effector function in vitro

BMC Pulmonary Medicine, 2007
Background We previously reported that NKG2A, a key inhibitory ligand for HLA-E, is expressed on activated TH2 but not TH1 cells. Here we measured cytokine expression in human ex vivo TH2 cells upon activation with anti-CD3/28 and challenge with an NKG2A-
Mojgani Bahar, Freishtat Robert J, Nazemzadeh Maryam, Nagaraju Kanneboyina, Hoffman Eric P   +4 more
doaj   +1 more source

Fast Reverse Design of 4D‐Printed Voxelized Composite Structures Using Deep Learning and Evolutionary Algorithm

Advanced Science, Volume 12, Issue 12, March 27, 2025.
A DL‐PEA system is developed by combining deep learning and evolutionary algorithms for the fast inverse design of 4D‐printed voxelized composite structures. DL‐PEA can accurately achieve the inverse design of target shapes by applying voxelization to hydrogels.
Mengtao Wang, Zaiyang Liu, Hidemitsu Furukawa, Zhuo Li, Yifei Ge, Yifan Xu, Zhe Qiu, Yang Tian, Zhongkui Wang, Ren Xu, Lin Meng   +10 more
wiley   +1 more source

A common factor regulates both Th1- and Th2-specific cytokine gene expression. [PDF]

, 1994
John W. Rooney, Martin R. Hodge, Patricia G. McCaffrey, Arjun A. Rao, Laurie H. Glimcher   +4 more
openalex   +1 more source

Iron Deficiency Impairs Dendritic Cell Development and Function, Compromising Host Anti‐Infection Capacity

Advanced Science, EarlyView.
Iron deficiency reduces monocyte dendritic cell progenitor (MDP) numbers by inhibiting migration and proliferation while promoting apoptosis, subsequently reducing downstream common dendritic cell precursors (CDP) and dendritic cell (DC). Impaired DCs enter the lungs via blood circulation, where reduced antigen presentation impairs T‐cell activation ...
Quanzhong Ren, Xiaotong Xu, Zheng Dong, Jiahuang Qiu, Qing'e Shan, Rui Chen, Yajun Liu, Juan Ma, Sijin Liu   +8 more
wiley   +1 more source