Results 111 to 120 of about 165,252 (249)

Seismic analysis and design of tunnels within fault ground: A review

Deep Underground Science and Engineering, EarlyView.
The research methods of seismic response of tunnels within fault ground, including field investigations, analytical solutions, physical experiments, and numerical simulations, and seismic countermeasures are discussed. The present study examines the shortcomings and limitations of the current research and design, and puts forward proposals for future ...
Xingda Wang, Yujing Jiang, Xuepeng Zhang, Yuyong Jiao, Ningbo Li, Xiao Wang, Bo Li   +6 more
wiley   +1 more source

Biomarkers of lung congestion and injury in acute heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi, Gabriele Novello, Francesca Bursi, Anna Caretti, Noemi Furlotti, Ross Arena, Paola Argiento, Julio Núñez, Antoni Bayes‐Genis, Marco Metra   +9 more
wiley   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Reframing Eczema: Th2-Skewed Contact Sensitization, Atopy Patch Testing, and Systemic Contact Dermatitis. [PDF]

Curr Allergy Asthma Rep
Jacob SE, Scheman A, Nedorost S.
europepmc   +1 more source

Intelligent Control Framework of District Heating Systems Considering Waste Heat Utilization in Data Centers

Energy Science &Engineering, EarlyView.
A deep reinforcement learning–based control architecture is proposed to coordinate heat pumps, thermal storage, renewable energy, and demand response in data center waste heat recovery systems. The agent learns optimal control actions from system states and reward feedback to achieve electrical–thermal co‐optimization under realistic operational ...
Rendong Shen, Ruifan Zheng, Shengyuan Zhong, Lei Gu, Dongfang Yang, Jun Zhao   +5 more
wiley   +1 more source

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation. [PDF]

J Exp Med
Golec DP, Gazzinelli-Guimaraes PH, Chauss D, Yu K, Nagashima H, Cruz AC, Hill T, Ganesan S, Cannons JL, Perry JK, Nivelo L, Joshi I, Pereira N, Silva Oliveira FM, Zheng Y, Jean Pierre M, Druey KM, Lack JB, Dang EV, Nutman TB, Villarino AV, O'Shea JJ, Afzali B, Schwartzberg PL.   +23 more
europepmc   +1 more source

Surmounting Recalcitrant Airway Inflammatory Disorders With a Multi‐Targeting Therapeutic Strategy by Tannic Acid‐Modified CuInP2S6 Nanosheets

Exploration, EarlyView.
Our findings underscore a multi‐targeting strategy for severe airway inflammation that multi‐targeting nanoformulation C‐TA1 markedly attenuated airway inflammation by (1) cfDNA elimination to alleviate neutrophilic/eosinophilic inflammation mediated by the TLR9 pathway, (2) prevention of RONS‐induced tissue injury and inflammatory response, (3 ...
Ming Liu, Changyi Xu, Renqiang Ma, Xinran Xie, Ying Xie, Mengya Du, Zhaofeng Xu, Shuaiyin Zhang, Jian Li, Weiping Wen, Zhaoxu Tu   +10 more
wiley   +1 more source

Tryptophan metabolism reprogramming regulates Th1/Th2 immune balance and inhibits mast cell activation. [PDF]

Amino Acids
Huang D, Huang D, Su L, He C, Zhang X, Peng J, Fan L, Cao Y, Chen L, Tong H.   +9 more
europepmc   +1 more source

Ultrasmall Au10–12 Nanoclusters: A Novel Platform for 223Ra‐Targeted Tumor α‐Therapy

Exploration, EarlyView.
Encapsulating 223Ra in Au10‐12 nanoclusters and functionalizing them with RGD peptides enables targeted α‐therapy and immune microenvironment remodeling in non‐osseous tumors like triple‐negative breast cancer. This study establishes a foundational framework for novel 223Ra‐labeled α‐radiopharmaceuticals and shows strong potential for clinical ...
Yifei Jiang, Huizhen Yang, Guoping Jia, Wangxi Hai, Rongyi Huang, Peng Wang, Min Zhang, Danni Li, Yizhou Chen, Xiao Li, Biao Li, Chunfu Zhang   +11 more
wiley   +1 more source

A Question of Nature: Some Antigens Are Bound to Be Allergens

Frontiers in Immunology, 2014
Lain ePontes-de-Carvalho, Lain ePontes-de-Carvalho, Jose eMengel, Jose eMengel   +3 more
doaj   +1 more source