Results 111 to 120 of about 22,410 (257)

Nanotherapy for Neural Retinal Regeneration

open access: yesAdvanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu   +11 more
wiley   +1 more source

Subcellular Cavitation Bubbles Induce Cellular Mechanolysis and Collective Wound Healing in Ultrasound‐Inflicted Cell Ablation

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
This study develops an integrated platform for real‐time, on‐the‐fly imaging of focused ultrasound‐induced cell ablation and responses at cellular and subcellular levels. It reveals that focused ultrasound could induce cellular mechanolysis through subcellular cavitation bubbles growing under confined contact with cells.
Ziyue Bai, Zaimeng Li, Yue Shao
wiley   +1 more source

Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells

open access: yesAdvanced Science, EarlyView.
Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao   +11 more
wiley   +1 more source

NETs‐CD44‐IL‐17A Feedback Loop Drives Th17‐Mediated Inflammation in Behçet's Uveitis

open access: yesAdvanced Science, Volume 12, Issue 16, April 24, 2025.
In experimental autoimmune uveitis (EAU), neutrophils interact with T helper 17 (Th17) cells through neutrophil extracellular traps (NETs) to exert a pro‐inflammatory effect. In vitro and in vivo experiments identify that NETs promote IL‐17A secretion in Th17 cells via CD44, and increasing IL‐17A further induces more NETs formation.
Yi Wu   +11 more
wiley   +1 more source

Electret‐Inspired Charge‐Injected Hydrogel for Scar‐Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
This study presents an electret‐inspired charge‐injected self‐powered hydrogel (QOSP) for the treatment of second‐degree burn wounds infected with Staphylococcus aureus and Pseudomonas aeruginosa. The hydrogel effectively eliminates bacteria and enhances cell proliferation through electrical stimulation, thereby accelerating wound healing. Additionally,
Mujie Liu   +29 more
wiley   +1 more source

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