Results 191 to 200 of about 22,410 (257)

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

The NLRP3 inflammasome pathway contributes to chronic inflammation in experimental autoimmune uveitis

Animal Models and Experimental Medicine, EarlyView.
The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome, Ilva D. Rupenthal, Rachael L. Niederer, Odunayo O. Mugisho   +3 more
wiley   +1 more source

Comparative analysis of short‐term and long‐term LL‐37‐induced rosacea‐like mouse models: Histopathological features and inflammatory immune responses

Animal Models and Experimental Medicine, EarlyView.
The aim of this study was to improve the long‐term LL‐37 mouse model and compare the disease manifestations and pathophysiology of short‐term and long‐term LL‐37‐induced rosacea‐like models. The results show that the long‐term LL‐37 induced mouse model provides a practical animal model for further study of the pathological mechanism of severe rosacea ...
Yiling Wu, Chuanxi Zhang, Hui Jin, Ruiping Zheng, Tian Li, Fuyu Jin, Yaqian Li, Xuemin Gao, Hong Xu, Zhongqiu Wei, Jie Yang   +10 more
wiley   +1 more source

Down-Regulation of IL-4 Gene Transcription and Control of Th2 Cell Differentiation by a Mechanism Involving NFAT1

, 1997
Alexander Kiani, João P. B. Viola, Andrew H. Lichtman, Anjana Rao   +3 more
openalex   +1 more source

Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7- 1, B7-2 and CD28

, 1998
Mark Ryan
openalex   +1 more source

Sézary Syndrome—Eosinophilia Explained by a Blood Film

American Journal of Hematology, EarlyView.
Merel T. A. Soeterik, Joris Janssen, Leo M. Budel, Anton W. Langerak, Yorick Sandberg, Barbara J. Bain   +5 more
wiley   +1 more source

The Induction and Characterization of a Potential Rough‐Type Brucella Vaccine Candidate Strain RA343, and Its Safety, Protective Efficacy in Mouse and Guinea Pig Models

Animal Research and One Health, EarlyView.
Brucellosis is a zoonotic disease caused by Brucella spp. which seriously jeopardize the health and safety of animals and human beings. In this study, a genetically stable Brucella rough RA343 strain was obtained by cross‐induction. The virulence and protective efficacy of RA343 were subsequently assessed. Overall, the RA343 strain is a promising novel
Linjiao Li, Guangzhi Zhang, Minghe Liu, Lang Lv, Xiaowei Peng, Yu Feng, Xiaotong Yang, Jiabo Ding, Chunhai Liu, Jianhua Qin, Peng Li, Hui Jiang, Xuezheng Fan   +12 more
wiley   +1 more source

Plants, plant‐derived compounds, probiotics, and postbiotics as green agents to fight against poultry coccidiosis: A review

Animal Research and One Health, EarlyView.
Therapeutic effect of natural products on chicken coccidiosis. Abstract The intestinal tract is the main place for animals to digest food and absorb nutrients, which also serves as the first line of defense against pathogens that invade the internal environment.
Pan Chen, Kaili Liu, Taojing Yue, Yanan Lu, Senyang Li, Fuchun Jian, Shucheng Huang   +6 more
wiley   +1 more source

Metabolic Stress Expands Polyfunctional, Proinflammatory Th17 Cells in Patients With Psoriatic Arthritis for Whom There is Interleukin‐23–Independent Interleukin‐17 Production

Arthritis &Rheumatology, EarlyView.
Objective Genetic associations and blockade of the interleukin (IL)‐23/IL‐17 axis with monoclonal antibodies support a role for this pathway in patients with psoriatic arthritis (PsA). This study examines the requirement of IL‐23 for IL‐17 production and the role of the metabolic microenvironment in the expansion of Th17‐derived cells in patients with ...
Carmel B. Stober, Louise Ellis, Jane C. Goodall, Marc Veldhoen, J. S. Hill Gaston   +4 more
wiley   +1 more source

Effects of TH1 and TH2 cytokines on CD8+ cell response against human immunodeficiency virus: implications for long-term survival.

, 1995
Edward Barker, Carl E. Mackewicz, Jay A. Levy   +2 more
openalex   +1 more source