Results 91 to 100 of about 5,234,585 (193)

Neonatal Exposure to Antibiotics Triggers Obesity in Adulthood by Permanent Microbiota Dysbiosis and Reduction of Adipose Regulatory T Cells

Barrier Immunity, Volume 2, Issue 3, Page 147-164, September 2026.
ABSTRACT Neonatal dysbiosis of the gut microbiota represents a critical environmental factor promoting obesity, but the underlying immunological mechanisms remain unknown. We show here that neonatal treatment of mice with broad‐spectrum antibiotics for the first 3 weeks of life (NeoATB) resulted in the development of obesity and metabolic abnormalities
Peter Zanvit, Junji Xu, Wenjing Yang, Nancy Guo, Tianming Yu, Xue Jiao, Michaela Prochazkova, Wenwen Jin, Na Liu, Sang‐A Park, Cheryl Chia, Daxesh P. Patel, Dunfang Zhang, Nathan Goldberg, Alexander Cain, Frank J. Gonzalez, Yasmine Belkaid, Yingzi Cong, WanJun Chen   +18 more
wiley   +1 more source

Herbal Extracts and Plant‐Derived Bioactives in Atopic Dermatitis: Evidence, Mechanisms, Pediatric Safety, and Translational Priorities

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Food‐derived bioactives, herbal extracts, and standardized botanical products are being investigated as adjunctive strategies for atopic dermatitis. Their biological activity is shaped not only by plant source and nominal dose, but also by fermentation, drying, heating, extraction, food‐matrix binding, gastrointestinal transformation, and formulation ...
Muhuang Zeng, Qianlan Yuan, Shuojia Huang, Xiaofei Lu   +3 more
wiley   +1 more source

Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis.

PLoS ONE, 2010
BackgroundAlthough recent studies indicate a crucial role for IL-17A and IL-22 producing T cells in the pathogenesis of psoriasis, limited information is available on their frequency and heterogeneity and their distribution in skin in situ.Methodology ...
Pieter C M Res, Gamze Piskin, Onno J de Boer, Chris M van der Loos, Peter Teeling, Jan D Bos, Marcel B M Teunissen   +6 more
doaj   +1 more source

Inflammatory Aging‐Driven Immune Axis Imbalance and the Mechanisms of Chronicity in Elderly Atopic Dermatitis: A Systematic Review and Meta‐Analysis

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Elderly atopic dermatitis (elderly AD) is increasingly recognized as a chronic inflammatory skin disorder with immunopathological features that may differ from those in younger populations. Age‐related chronic low‐grade inflammation (inflammaging) may contribute to this phenotype, but its relationship with immune dysfunction and ...
Nan Wu, Yingjie Li, Xiaojie Wang, Yangyang Wu, Wenhao Yin   +4 more
wiley   +1 more source

ART interruption severely decreases IL-17 and IL-22 producing cell function and levels.

, 2016
(A) Levels of RB Th17 (red), Th22 (blue), and Th17/Th22 (green) cells, measured as percentages of total CD4+ T-cell population, significantly decreased following ART interruption (180 days off-ART). Averaged data are presented as means ± SEM.
Luca Micci (427502), Mirko Paiardini (243070), Nicolas Chomont (175516), Rémi Fromentin (659658), Colleen S. McGary (430430), Sara Paganini (2172766), Emily S. Ryan (651787), Kirk Easley (356159)   +7 more
core   +1 more source

Supplementary Material for: Staphylococcal Exotoxins Induce Interleukin 22 in Human Th22 Cells

, 2017
Background: We have shown previously that T cells from atopic dermatitis (AD) patients produce more IL-22 upon staphylococcal exotoxin stimulation compared to psoriasis patients and healthy controls.
Satzger I. (3355949), Werfel T. (4148740), Mainardy J. (4148749), Heratizadeh A. (4148746), Niebuhr M. (4148743)   +4 more
core   +1 more source

T Helper 22 Pathway Evaluation in Type 1 Diabetes and Its Complications

Iranian Journal of Allergy, Asthma and Immunology, 2018
A subset of CD4+ T cells named T helper (Th)22 cells play some pathogenic roles in some autoimmune disorders such as type 1 diabetes (T1D). We aimed to study the correlation between the circulatory number of these cells and serum levels of its related ...
Hossein Akbari, Mostafa Ghardashi, Alireza Soleimani, Hanieh Mohammadi, Hassan Nikoueinejad   +4 more
doaj  

ART treatment is insufficient for full restoration of cell subset levels and function.

, 2016
(A-C) Longitudinal functional scores of Th17, Th22, and Th17/Th22 cells in RB at pre-infection (d. -20 p.i.), pre-ART (d. 58 p.i.), and throughout ART (d. 84 p.i. through d. 256 p.i.).
Luca Micci (427502), Mirko Paiardini (243070), Nicolas Chomont (175516), Rémi Fromentin (659658), Colleen S. McGary (430430), Sara Paganini (2172766), Emily S. Ryan (651787), Kirk Easley (356159)   +7 more
core   +1 more source

2406 The microbial-derived short-chain fatty acid butyrate directly and differentially inhibits gut T helper cell subset activation and proliferation

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: A hallmark of progressive HIV-1 infection is the massive activation and depletion of the gut barrier protective CD4 T helper subsets (Th17 and Th22) in the intestinal mucosa.
Jon Kibbie, Stephanie Dillon, Moriah Castleman, Jay Liu, Martin McCarter, Cara Wilson   +5 more
doaj   +1 more source

Identifizierung und Charakterisierung neuer regulierender Faktoren von Th17 und Th22-Zellen

, 2018
This study identified an upregulated expression of LINGO4 in Th17 cells and FOXO4 in IL-22 producing as well as Th22 cells. LINGO4 expression strongly correlated with the expression of the key transcription factor of Th17 cells, RORC2, and was identified
Atenhan, Anne
core