Results 101 to 110 of about 5,234,585 (193)

Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis

Molecular Medicine Reports, 2016
Psoriasis is a common chronic inflammatory and T cell-meditated skin disease. Runt-related transcription factor 3 (RUNX3), one of the runt‑domain family of transcription factors, has been reported to be a susceptibility gene for psoriasis. The present study was designed to delineate the role and underlying mechanism of RUNX3 involved in the ...
FU, DANDAN, SONG, XIANGFENG, HU, HUA, SUN, MIN, LI, ZHANGUO, TIAN, ZHONGWEI   +5 more
openaire   +3 more sources

T-helper 22 cells develop as a distinct lineage from Th17 cells during bacterial infection and phenotypic stability is regulated by T-bet.

, 2021
CD4+ T-helper 22 (Th22) cells are a phenotypically distinct lymphocyte subset that produces high levels of interleukin (IL)-22 without co-production of IL-17A.
Foster, PS, Hansbro, PM, Lochrin, A, Belz, GT, Plank, MW, Tay, HL, Barnes, JL, Asquith, K, Sabino, LR, Keely, S, Mayall, JR, Maltby, S, Kaiko, GE, Horvat, JC, Kim, RY, Lorena R. Sabino, Paul S. Foster, Richard Y. Kim, Jessica L. Barnes, Kelly Asquith, Simon Keely, Gabrielle T. Belz, Alyssa Lochrin, Philip M. Hansbro, Jemma R. Mayall, Maximilian W. Plank, Hock L. Tay, Gerard E. Kaiko, Steven Maltby, Jay C. Horvat   +29 more
core   +1 more source

Increased frequency of circulating Th22 cells in patients with B-cell non-Hodgkin's lymphoma

Oncotarget, 2016
T helper (Th) 22 cells play important roles in the pathogenesis of autoimmune and inflammatory diseases, and their function in tumors remains uncertain. In the current study, we investigated the alternations and clinical significance of circulating Th22 cells in patients with B-cell non-Hodgkin's lymphoma (B-NHL).
Lu, Ting, Liu, Yan, Yu, Shuang, Yin, Congcong, Li, Peng, Ye, Jingjing, Ma, Daoxin, Ji, Chunyan   +7 more
openaire   +3 more sources

Correlation between Th17 and Th22 and CD26 cell subsets.

, 2015
A) In the whole cohort, the frequency of CD45R0+CD26- subset correlates negatively with the Th17 CCR4- cells but positively with the other Th17 and Th22 subsets (Th22CCR4- did not correlate in the whole cohort but it did among different patients’ groups,
José María Pego (770190), Cristina Calviño-Sampedro (770184), Marina Rodríguez-López (770188), Coral Mouriño (770186), Íñigo Hernández-Rodríguez (770187), Tania López-González (770183), Juan E. Viñuela (770185), Oscar J. Cordero (628413), Bruno Aspe de la Iglesia (770189), Rubén Varela-Calviño (770182)   +9 more
core   +1 more source

Effect of methimazole treatment on Th1, Th17, and Th22 lymphocytes in pediatric Graves’ disease patients [PDF]

Graves’ disease is the leading cause of autoimmune hyperthyroidism. Thyroid hormones are an essential element of the endocrine system, playing a pivotal role in the body’s development, especially important in children with intensified growth. Disturbance
Kamil Grubczak, Aleksandra Opęchowska, Marcin Moniuszko, Filip Bossowski, Artur Bossowski, Aleksandra Starosz, Karolina Stożek   +6 more
core   +1 more source

Increased circulating Th22 cells in patients with acute gouty arthritis

Medicine, 2017
T-helper 22 (Th22) cells are involved in host immunity against pathogen invasion and have been implicated in the pathogenesis of inflammatory diseases. However, the roles of Th22 cells in acute gouty arthritis remain unclear.A case-control study was employed to illustrate the clinical significance of Th22 cells in acute gouty arthritis.
Luo, Guangcheng, Yi, Tingting, Zhang, Guoyuan, Guo, Xiaolan, Jiang, Xingliang   +4 more
openaire   +2 more sources

The Imbalance between Foxp3+Tregs and Th1/Th17/Th22 Cells in Patients with Newly Diagnosed Autoimmune Hepatitis

, 2018
This study is aimed at examining the potential role of regulatory T- (Treg-) Th1-Th17-Th22 cells in the pathogenic process of autoimmune hepatitis (AIH). The numbers of Foxp3+Tregs and Th1, Th17, and Th22 cells were measured in 32 AIH patients using flow
Zhuang Yun, Ma Liang, Ding Yanbo, Zhang Liwen, Chen Jianping   +4 more
core   +1 more source

Differential human Th22-lymphocyte response triggered by Aggregatibacter actinomycetemcomitans serotypes

, 2017
Objective: In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on lipopolysaccharide (LPS) antigenicity. When T lymphocytes were stimulated with these serotypes, different patterns of T-helper (Th)1 and Th17-type of ...
Rolando Vernal, Jaime Díaz-Zúñiga, Myriam Pujol, Leticia Rojas, Carla Alvarez, Gustavo Monasterio, Paola Carvajal, Samanta Melgar-Rodríguez, Alvarez C., Rojas L., Díaz-Zúñiga J., Melgar-Rodríguez S., Carvajal P., Vernal R., Monasterio G., Pujol M.   +15 more
core   +2 more sources

Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17/Th1 cell in patients with acute coronary syndrome.

, 2013
BackgroundAtherosclerosis is a chronic inflammatory disease mediated by immune cells. Th22 cells are CD4(+) T cells that secret IL-22 but not IL-17 or IFN-γ and are implicated in the pathogenesis of inflammatory disease.
Xiao-qi Wang, Guo-hai Su, Rui-zhi Du, Shuang Yu, Zhen-hua Li, Xin-guang Liu, Dao-xin Ma, Ting Wang, Kai-ning Zhang, Lei Zhang, Nai-li Du, Yu-qing Guan   +11 more
core   +1 more source

IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection. [PDF]

, 2013
Type 2 immune responses are essential in protection against intestinal helminth infections. In this study we show that IL-22, a cytokine important in defence against bacterial infections in the intestinal tract, is also a critical mediator of anti ...
Stockinger, Brigitta, Helmby, Helena, Brigitta Stockinger, Helmby Helena, Turner, Jan-Eric, Helena Helmby, Turner Jan-Eric, Stockinger Brigitta, Jan-Eric Turner   +8 more
core   +1 more source