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Increased Th22 cells are independently associated with Th17 cells in type 1 diabetes
Endocrine, 2013Type 1 diabetes (T1D) is perceived as an autoimmune disease caused by T cell-mediated destruction of the insulin-producing pancreatic β cells. However, the number of inflammatory T cells in blood, as well as the relative importance of each cell type is unclear. Forty-two patients with T1D and 30 controls were enrolled. Circulating primary CD4(+) or CD8(
Xinyu, Xu +7 more
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Th22 Cells Induce Müller Cells Activation Via the Act1/Traf6 Pathway in Diabetic Retinopathy
SSRN Electronic Journal, 2022T helper 22 (Th22) cells have been implicated in diabetic retinopathy (DR), but it remains unclear whether Th22 cells involve in the pathogenesis of DR. To investigate the role of Th22 cells in DR mice, the animal models were established by intraperitoneal injection of STZ and confirmed by fundus fluorescein angiography and retinal haematoxylin-eosin ...
Yufei Wang +9 more
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Clinica Chimica Acta, 2013
Immune regulation is important for the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL). Th22 cells are recently-identified CD4(+) T cells that implicated in the pathogenesis of many hematological diseases, such as AML. However, the role of Th22 cells in the pathophysiology of T-ALL remains unclear.
Cunzhong Yuan, Daoxin Ma, Na He
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Immune regulation is important for the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL). Th22 cells are recently-identified CD4(+) T cells that implicated in the pathogenesis of many hematological diseases, such as AML. However, the role of Th22 cells in the pathophysiology of T-ALL remains unclear.
Cunzhong Yuan, Daoxin Ma, Na He
exaly +3 more sources
The role of IL-22 and Th22 cells in human skin diseases
Journal of Dermatological Science, 2013Interleukin (IL)-22 is a cytokine that is involved in the modulation of tissue responses during inflammation. It is produced by immune cell subsets such as T cells, while the expression of its receptor is restricted to cells of non-hematopoietic origin, particularly epithelial cells.
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Th22 cells in autoimmunity: a review of current knowledge.
European annals of allergy and clinical immunology, 2015Newly identified T helper cell 22 (Th22) is a subset of CD4+ T cells with specific properties apart from other known CD4+ T cell subsets. Th22 is obviously discrete from Th17 and Th1 subsets by production of interleukin (IL)-22 but not IL-17 or IFN-γ, and also with distinguished expression of aryl hydrocarbon receptor (AHR) as the key transcription ...
G, Azizi, R, Yazdani, A, Mirshafiey
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Pathogenic Th17 and Th22 cells are increased in patients with autoimmune thyroid disorders
Endocrine, 2017To study the levels of pathogenic and non-pathogenic Th17 and Th22 cells in autoimmune thyroid disorders patients. Although Th17 cells seem to play an important role in the pathogenesis of thyroid autoimmune disorders, the specific subsets of these lymphocytes have not been analyzed in this condition.We assessed the levels of Th17 (pathogenic and non ...
Marlen, Vitales-Noyola +6 more
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[Change and significance of Th22 cells in patients with aplastic anemia].
Zhonghua yi xue za zhi, 2014To explore the proportion of Th22 cells in peripheral blood of patients with aplastic anemia (AA) and evaluate its significance.From January 2011 to June 2012, a total of 47 AA patients were recruited and divided into 4 groups: severe aplastic anemia (SAA) pre-therapy (group A, n = 11), non-severe aplastic anemia (NSAA) pre-therapy (group B, n = 12 ...
Li-min, Liu +7 more
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