Crosstalk between ILC2s and Th2 cells varies among mouse models. [PDF]
Cell Rep, 2023 Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are still
Gurram RK +14 more
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Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis. [PDF]
Front Immunol, 2022 Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, to trigger inflammatory responses.
Kokubo K +5 more
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SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells. [PDF]
Respir Res, 2021 Background Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role in the T-helper type 2 (Th2) response of allergic asthma is not known.
Mo Y +8 more
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Differentiation and Regulation of Bovine Th2 Cells In Vitro. [PDF]
CellsBovine Th2 cells have usually been characterized by IL4 mRNA expression, but it is unclear whether their IL4 protein expression corresponds to transcription.
Kandel A, Li L, Wang Y, Tuo W, Xiao Z.
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Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. [PDF]
PLoS One, 2021 Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine.
Iwasaki N +6 more
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New Insights into HIV Life Cycle, Th1/Th2 Shift during HIV Infection and Preferential Virus Infection of Th2 Cells: Implications of Early HIV Treatment Initiation and Care. [PDF]
Life (Basel)The theory of immune regulation involves a homeostatic balance between T-helper 1 (Th1) and T-helper 2 (Th2) responses. The Th1 and Th2 theories were introduced in 1986 as a result of studies in mice, whereby T-helper cell subsets were found to direct ...
Hokello J +6 more
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An in silico approach for modelling T-helper polarizing iNKT cell agonists [PDF]
, 2014 Many analogues of the glycolipid alpha-galactosylceramide (α-GalCer) are known to activate iNKT cells through their interaction with CD1d-expressing antigen-presenting cells, inducing the release of Th1 and Th2 cytokines. Because of iNKT cell involvement
ASPESLAGH, SANDRINE +9 more
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Interleukin-33/ST2: A new signaling pathway in immunity and immunopathology [PDF]
Vojnosanitetski Pregled, 2012 nema
Pavlović Slađana +5 more
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Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity. [PDF]
PLoS ONE, 2013 Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear.
Tetsuya Sasaki +9 more
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Increased Proportion of Dual-Positive Th2–Th17 Cells Promotes a More Severe Subtype of Asthma
Canadian Respiratory Journal, 2021 Asthma is a heterogeneous disease, and abnormal activation of T cells is the driving link of asthma’s pathophysiological changes. Dual-positive Th2–Th17 cells, as newly discovered T-helper cells, have the functions of Th2 and Th17 cells and can coproduce
Wenjin Sun +9 more
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