Results 11 to 20 of about 158,259 (287)

Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity. [PDF]

PLoS ONE, 2013
Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear.
Tetsuya Sasaki, Atsushi Onodera, Hiroyuki Hosokawa, Yukiko Watanabe, Shu Horiuchi, Junji Yamashita, Hitoshi Tanaka, Yasumasa Ogawa, Yutaka Suzuki, Toshinori Nakayama   +9 more
doaj   +1 more source

Increased Proportion of Dual-Positive Th2–Th17 Cells Promotes a More Severe Subtype of Asthma

Canadian Respiratory Journal, 2021
Asthma is a heterogeneous disease, and abnormal activation of T cells is the driving link of asthma’s pathophysiological changes. Dual-positive Th2–Th17 cells, as newly discovered T-helper cells, have the functions of Th2 and Th17 cells and can coproduce
Wenjin Sun, Yu Yuan, Lulu Qiu, Qingping Zeng, Jingsi Jia, Xudong Xiang, Aijun Jia, Libing Ma, Shaokun Liu, Bing Xiao   +9 more
doaj   +1 more source

Eosinophils: Cells known for over 140 years with broad and new functions

Allergology International, 2021
Eosinophils are multifunctional leukocytes, being involved in the host defense against helminth infection, tissue homeostasis and repair of injured tissue.
Ami Aoki, Kiyoshi Hirahara, Masahiro Kiuchi, Toshinori Nakayama   +3 more
doaj   +1 more source

Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment

Frontiers in Immunology, 2021
The function of T cells is critically dependent on their ability to generate metabolic building blocks to fulfil energy demands for proliferation and consecutive differentiation into various T helper (Th) cells.
Simon Schreiber, Christoph M. Hammers, Achim J. Kaasch, Achim J. Kaasch, Burkhart Schraven, Burkhart Schraven, Anne Dudeck, Anne Dudeck, Sascha Kahlfuss, Sascha Kahlfuss, Sascha Kahlfuss   +10 more
doaj   +1 more source

CD11a polymorphisms regulate TH2 cell homing and TH2-related disease [PDF]

Journal of Allergy and Clinical Immunology, 2014
TH2-dependent diseases vary in severity according to genotype, but relevant gene polymorphisms remain largely unknown. The integrin CD11a is a critical determinant of allergic responses, and allelic variants of this gene might influence allergic phenotypes.We sought to determine major CD11a allelic variants in mice and human subjects and their ...
Knight, John, Lee, Seung-Hyo, Roberts, Luz, Smith, C. Wayne, Weiss, Scott, Kheradmand, Farrah, Corry, David B.   +6 more
openaire   +3 more sources

Phenotypic Analysis of Nasal CD69 CD4 Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps [PDF]

Journal of Rhinology
Background and Objectives Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease, classified into eosinophilic and non-eosinophilic subtypes. Although CD4+ tissue-resident memory T (TRM) cells play diverse roles in tissue homeostasis, their
Min-Seok Rha, Gyeongyeob Kim, Sol Lee
doaj   +1 more source

Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells

Frontiers in Cellular and Infection Microbiology, 2017
Infections by the soil-transmitted threadworm Strongyloides stercoralis affect 30–100 million people worldwide, predominantly in tropic and sub-tropic regions. Here we assessed the T helper cell phenotypes in threadworm-infected patients and experimental
Cristin N. Bock, Subash Babu, Subash Babu, Minka Breloer, Anuradha Rajamanickam, Yukhti Boothra, Marie-Luise Brunn, Anja A. Kühl, Roswitha Merle, Max Löhning, Max Löhning, Susanne Hartmann, Sebastian Rausch   +12 more
doaj   +1 more source

Immune cell profiling of atopic dermatitis patients before and after treatment with halometasone cream wet-wrap therapy by single-cell sequencing

Indian Journal of Dermatology, 2023
Objectives: Peripheral blood immune cell profiling of atopic dermatitis patients before and after treatment by single-cell RNA sequencing technique has not been reported.
Xiao-Guang Gu, Xin Yu, Bo-Yang Zhou, Ming Li, Wei Xu, Yan Li, Lin-Feng Li   +6 more
doaj   +1 more source

Alarming dendritic cells for Th2 induction [PDF]

The Journal of Experimental Medicine, 2008
There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses.
MacDonald, Andrew S., Maizels, Rick M.
openaire   +5 more sources

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. [PDF]

The Journal of Immunology, 2007
AbstractIL-27 up-regulates Th1 but down-regulates Th2 responses. However, its molecular mechanism and regulatory effects on polarized Th2 cells remain unclear. In this study, we have revealed that IL-27 inhibits Th2 cell development as well as Th2 cytokines production from already polarized Th2 cells by down-regulation of GATA-3 and up-regulation of T ...
Tomohiro, Yoshimoto, Takayuki, Yoshimoto, Koubun, Yasuda, Junichiro, Mizuguchi, Kenji, Nakanishi   +4 more
openaire   +3 more sources