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Crossregulation Between Th1 and Th2 Cells
Critical Reviews™ in Immunology, 1998Th1 and Th2 subsets have been characterized on the basis of the cytokines they secrete and the immune functions they mediate. Th1 cells secrete IL-2, IFN-gamma, and lymphotoxin and are important in the cell-mediated response; Th2 cells secrete IL-4, IL-5, IL-10, and IL-13 and are important in the control of macrophage function and in the stimulation of
P A, Morel, T B, Oriss
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TH2 and ‘TH2-like’ cells in allergy and asthma: pharmacological perspectives
Trends in Pharmacological Sciences, 1994Recently, considerable progress has been made in understanding the molecular basis by which cytokines released from CD4+ helper T cells contribute to allergic disease. A subset of CD4+ helper T cells, termed TH2 cells, produce interleukin 4 (IL-4) and IL-5, but not interferon gamma.
G P, Anderson, A J, Coyle
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Targeting Th2 Cells in Asthmatic Airways
2010Asthma represents a profound worldwide public health problem. The most effective anti-asthmatic drugs currently available include inhaled β2 -agonists and glucocorti-coids; these control asthma in about 90–95% of patients. However, the future therapies will need to focus on the 5–10% patients who do not respond well to these treatments and who account ...
CARAMORI, Gaetano +5 more
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T-cell subsets (Th1 versus Th2)
Annals of Allergy, Asthma & Immunology, 2000To understand the current status of knowledge in the basic field of polarized specific immune responses mediated by CD4+ T helper (Th) lymphocytes, based on their profile of cytokine production (type 1 or Th1 and type 2 or Th2).Relevant articles and publications from the medical literature, especially review articles dealing with properties, mechanisms
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[Th1 cells, Th2 cells and atopic dermatitis].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1997The immunological hallmark of atopic dermatitis (AD) is a Th1/Th2 dysbalance. The reaction to high molecular weight environmental allergens (e.g. pollen, house dust mites), production of IgE and activation of eosinophil granulocytes result from Th2 dominance. The Th2-cytokine interleukin-4 (IL-4) is necessary for IgE synthesis.
I, Böhm, R, Bauer
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Dendritic cell regulation of TH1-TH2 development
Nature Immunology, 2000Understanding the control exerted by cytokines on T helper cell subsets 1 and 2 (TH1-TH2) development has progressed to a fairly satisfying knowledge of intracellular signals and transcription factors. Less is understood about the molecular basis of TH1-TH2 development exerted by other parameters, such as how the antigen presenting cell can influence ...
Moser, Muriel, Murphy, Kevin
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Biology of human TH1 and TH2 cells
Journal of Clinical Immunology, 1995Evidence is accumulating to suggest the existence of polarized human T-cell responses, reminiscent of TH1 and TH2 subsets described for mouse T cells. Human TH1 cells preferentially develop during infections by intracellular bacteria and trigger phagocyte-mediated host defense, whereas TH2 cells, which predominate during helminthic infestations and in ...
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Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology, 2019
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