Results 21 to 30 of about 158,259 (287)
Frontiers in Immunology, 2018 Antigen-primed T cells respond to restimulation much faster than naïve T cells and form the cellular basis of immunological memory. The formation of memory Th2 cells starts when naïve CD4 T cells are transformed into effector Th2 cells and is completed ...
Atsushi Onodera +3 more
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JID Innovations, 2021 Group 2 innate lymphoid cells (ILCs) are thought to contribute to the pathogenesis of atopic dermatitis (AD). IL-4 stimulates T helper type 2 (Th2) cells and ILC2s to proliferate and produce cytokines. Dupilumab, an antibody against the IL-4 receptor, is
Yasutomo Imai +4 more
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PLoS Neglected Tropical Diseases, 2019 T cell-intrinsic regulation, such as anergy, adaptive tolerance and exhaustion, is central to immune regulation. In contrast to Type 1 and Type 17 settings, knowledge of the intrinsic fate and function of Th2 cells in chronic Type 2 immune responses is ...
Johanna A Knipper +2 more
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Mercury: god of Th2 cells? [PDF]
Clinical and Experimental Immunology, 1995 link_to_subscribed_fulltext
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Beyond CCR7: dendritic cell migration in type 2 inflammation
Frontiers in ImmunologyConventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues
Audrey Meloun +2 more
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Pathogenic Effector Th2 Cells in Allergic Eosinophilic Inflammatory Disease
Frontiers in Medicine, 2017 There is an absolute requirement for Th2 cells in the pathogenesis of allergen-driven eosinophil-rich type 2 inflammation. Although Th2 cells are generally regarded as a homogeneous population, in the past decade there has been increasing evidence for a ...
Alyssa Mitson-Salazar, Calman Prussin
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Impact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis
Frontiers in Immunology, 2017 Enhancer of zeste homolog 2 (Ezh2) has been shown to play a role in the differentiation of T helper (Th) 1 and 2 cells in mice studies using Ezh2-deficient T cells.
Tsung-Yun Hou +10 more
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NKG2A inhibits TH2 cell effector function
BMC Pulmonary Medicine, 2007 Background We previously reported that NKG2A, a key inhibitory ligand for HLA-E, is expressed on activated TH2 but not TH1 cells. Here we measured cytokine expression in human ex vivo TH2 cells upon activation with anti-CD3/28 and challenge with an NKG2A-
Mojgani Bahar +4 more
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Thymic Stromal Lymphopoietin and Cancer: Th2-Dependent and -Independent Mechanisms
Frontiers in Immunology, 2020 The thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine originally cloned from a murine thymic stromal cell line, and subsequently a human homolog was identified using database search methods.
Maria Pia Protti +3 more
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Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells. [PDF]
PLoS ONE, 2009 Inducible Costimulator (ICOS) is an important regulator of Th2 lymphocyte function and a potential immunotherapeutic target for allergy and asthma. A SNP in the ICOS 5' promoter in humans is associated with increased atopy and serum IgE in a founder ...
Bryan S Clay +7 more
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