Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity. [PDF]
PLoS ONE, 2013 Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear.
Tetsuya Sasaki +9 more
doaj +1 more source
Alarming dendritic cells for Th2 induction [PDF]
The Journal of Experimental Medicine, 2008 There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses.
MacDonald, Andrew S., Maizels, Rick M.
openaire +5 more sources
An in silico approach for modelling T-helper polarizing iNKT cell agonists [PDF]
, 2014 Many analogues of the glycolipid alpha-galactosylceramide (α-GalCer) are known to activate iNKT cells through their interaction with CD1d-expressing antigen-presenting cells, inducing the release of Th1 and Th2 cytokines. Because of iNKT cell involvement
ASPESLAGH, SANDRINE +9 more
core +6 more sources
Regulation of Th2 Cell Immunity by Dendritic Cells [PDF]
Immune Network, 2016 Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell ...
Hyeongjin Na +2 more
openaire +3 more sources
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]
, 2017 IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri +8 more
core +1 more source
Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment
Frontiers in Immunology, 2021 The function of T cells is critically dependent on their ability to generate metabolic building blocks to fulfil energy demands for proliferation and consecutive differentiation into various T helper (Th) cells.
Simon Schreiber +10 more
doaj +1 more source
Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells [PDF]
The Journal of Immunology, 2017 Abstract Posttranslational modifications of histones are well-established epigenetic modifications that play an important role in gene expression and regulation. These modifications are partly mediated by the Trithorax group (TrxG) complex, which regulates the induction or maintenance of gene transcription.
Atsushi Onodera +8 more
openaire +3 more sources
Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma [PDF]
, 2017 The pathophysiology of allergic asthma is driven by T-helper 2 (Th2) immune responses following aeroallergen inhalation. The mechanisms that initiate, potentiate and regulate airways allergy are incompletely characterized.
Crompton, Tessa +4 more
core +2 more sources
Enhanced mechanical heterogeneity of cell collectives due to temporal fluctuations in cell elasticity [PDF]
Phys. Rev. E 107, 014401 (2023), 2022 Cells are dynamic systems characterized by temporal variations in biophysical properties such as stiffness and contractility. Recent studies show that the recruitment and release of actin filaments into and out of the cell cortex - a network of proteins underneath the cell membrane - leads to cell stiffening prior to division and softening immediately ...
arxiv +1 more source
Suppression of allergic airway inflammation by helminth-induced regulatory T cells [PDF]
, 2005 Allergic diseases mediated by T helper type (Th) 2 cell immune responses are rising dramatically in most developed countries. Exaggerated Th2 cell reactivity could result, for example, from diminished exposure to Th1 cell–inducing microbial infections ...
Balic, Adam +5 more
core +2 more sources