Results 101 to 110 of about 107,712 (298)

Fast-track strategy for the prevention of Hb Bart’s hydrops fetalis syndrome

Thalassemia Reports, 2017
We propose a fast-track strategy [direct blood DNA analysis using a quantitative real-time polymerase chain reaction (PCR) technique] for the early risk detection and prenatal diagnosis of α(0)-thalassemia (SEA and Thai deletion).
Narutchala Suwannakhon, Khajohnsilp Pongsawatkul, Teerapat Seeratanachot, Wirawan Rasri, Khwanruedee Mahingsa, Arunee Pingyod, Wanwipa Bumrungpakdee, Torpong Sanguansermsri   +7 more
doaj   +1 more source

Beta-thalassemia: renal complications and mechanisms: a narrative review

Hematology, 2019
Objectives: Beta-thalassemias are a group of recessively autosomal inherited disorders of hemoglobin synthesis, which, due to mutations of the beta-globin gene, lead to various degrees of defective beta-chain production, an imbalance in alpha/beta-globin
C. Demosthenous, E. Vlachaki, C. Apostolou, P. Eleftheriou, A. Kotsiafti, Evangelia Vetsiou, E. Mandala, V. Perifanis, P. Sarafidis   +8 more
semanticscholar   +1 more source

Iron overload and morbidities in Chinese with non‐transfusion‐dependent thalassaemia

British Journal of Haematology, EarlyView.
A cross‐sectional study in Hong Kong included 109 adult and paediatric Chinese patients with non‐transfusion dependent thalassaemia (NTDT). The study found significant chronic health issues in 52% of patients. More severe disease was observed in patients with non‐deletional α‐thalassaemia intermedia, β‐thalassaemia intermedia, advanced age and history ...
Wing‐yan Leung, Tracy Yuen‐han Lee, Yu‐yan Hwang, Jasmine Tsz‐man Lee, Chun‐Fung Sin, Sio‐peng Mok, Chung‐yin Ha, Allen Li, Wendy Wai‐man Lam, Man‐fung Yuen, Yok‐lam Kwong, Dorine W. Swinkels, Coby M. Laarakkers, Daniel Ka‐leung Cheuk, Godfrey Chi‐fung Chan, Chak‐ho Li, Yiu‐fai Cheung, Chi Chiu So, Shau‐yin Ha, Anthony Pak‐yin Liu   +19 more
wiley   +1 more source

Prognostic significance of mutated genes in megakaryocytic disorders

Oncology Reviews, 2019
Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors.
Ali Amin Asnafi, Mohammad bagher Mohammadi, Hadi Rezaeeyan, Nader Davari, Najmaldin Saki   +4 more
doaj   +1 more source

Laboratory assessment of fetomaternal haemorrhage and Rh immune globulin management: Canadian practice and scoping review

British Journal of Haematology, EarlyView.
Fetomaternal haemorrhage (FMH) in RhD‐negative individuals can cause alloimmunization with future antibody‐mediated destruction of fetal red blood cells. Accurate FMH estimation guides Rh immune globulin dosing. The rosette test, the most used qualitative method, may yield false negatives with fetal RhD variants or false positives with maternal ...
Omar I. Hajjaj, Jeannie Callum, Nadine Shehata, Ashley Farrell, Gwen Clarke, Lani Lieberman   +5 more
wiley   +1 more source

Thalassemia and Hemoglobin E in Southern Thai Blood Donors

Advances in Hematology, 2014
Thalassemia and hemoglobin E (Hb E) are common in Thailand. Individuals with thalassemia trait usually have a normal hemoglobin concentration or mild anemia. Therefore, thalassemic individuals who have minimum acceptable Hb level may be accepted as blood
Manit Nuinoon, Kwanta Kruachan, Warachaya Sengking, Dararat Horpet, Ubol Sungyuan   +4 more
doaj   +1 more source

Multiple Inherited Erythrocyte Abnormalities in an American Negro Family: Hereditary Spherocytosis, Sickling and Thalassemia [PDF]

, 1959
Flossie Cohen, Wolf W. Zuelzer, James V. Neel, Abner R. Robinson   +3 more
openalex   +1 more source

Minihepcidins improve ineffective erythropoiesis and splenomegaly in a new mouse model of adult β-thalassemia major

Haematologica, 2019
Minihepcidins are hepcidin agonists that have been previously shown to reverse iron overload and improve erythropoiesis in mice affected by non-transfusion-dependent thalassemia.
C. Casu, Roberta Chessa, Alison Liu, Ritama Gupta, H. Drakesmith, R. Fleming, Y. Ginzburg, B. Macdonald, S. Rivella   +8 more
semanticscholar   +1 more source

BRAF mutation in hairy cell leukemia

Oncology Reviews, 2014
BRAF is a serine/threonine kinase with a regulatory role in the mitogen-activated protein kinase (MAPK) signaling pathway. A mutation in the RAF gene, especially in BRAF protein, leads to an increased stimulation of this cascade, causing uncontrolled ...
Ahmad Ahmadzadeh, Saeid Shahrabi, Kaveh Jaseb, Fatemeh Norozi, Mohammad Shahjahani, Tina Vosoughi, Saeideh Hajizamani, Najmaldin Saki   +7 more
doaj   +1 more source

FURTHER STUDIES ON THE GENETICS OF THALASSEMIA [PDF]

, 1947
James V. Neel, William N. Valentine
openalex   +1 more source