Results 31 to 40 of about 107,712 (298)
Epidemiology of the Incidence, Prevalence, and Mortality of Thalassemia in Iran: A Secondary Analysis of Global Burden of Disease 2019. [PDF]
Health Sci RepABSTRACT Background and Aims Compared to other regions, Iran is one of the countries where the prevalence of thalassemia is higher. The purpose of the present study is to investigate the epidemiology of the incidence, prevalence, and mortality of thalassemia in Iran. Methods The present study is a correlation analysis.
Sheikhi K +6 more
europepmc +2 more sources
New England Journal of Medicine, 2014 More than 100 varieties of α-thalassemia have been identified. Their geographic distribution and the challenges associated with screening, diagnosis, and management suggest that α-thalassemias should have a higher priority on global public health agendas.
Longo, DL, Piel, FB, Weatherall, DJ
openaire +5 more sources
Hematology, 2012 Thalassemia is the most common form of inherited anemia worldwide. The World Health Organization reports suggest that about 60,000 infants are born with a major thalassemia every year. Although individuals originating from the tropical belt are most at risk, it is a growing global health problem due to extensive population migrations. Despite important
openaire +5 more sources
Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation
Drugs, 2020 Hemoglobinopathies are among the most common monogenic diseases worldwide. Approximately 1–5% of the global population are carriers for a genetic thalassemia mutation.
I. Motta +3 more
semanticscholar +1 more source
Thalassemias: An Overview [PDF]
International Journal of Neonatal Screening, 2019 Thalassemia syndromes are among the most serious and common genetic conditions. They are indigenous in a wide but specific geographical area. However, through migration they are spreading across regions not previously affected. Thalassemias are caused by mutations in the α (HBA1/HBA2) and β globin (HBB) genes and are usually inherited in an autosomal ...
Michael Angastiniotis, Stephan Lobitz
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International Journal of Environmental Research and Public Health, 2020 Alpha(α)-thalassemia is a blood disorder caused by many types of inheritable α-globin gene mutations which causes no-to-severe clinical symptoms, such as Hb Bart’s hydrops fetalis that leads to early foetal death. Therefore, the aim of this meta-analysis
L. P. W. Goh, E. Chong, Ping-Chin Lee
semanticscholar +1 more source
Nature Network Boston, 2020 β-Thalassemia pathology is due not only to loss of β-globin (HBB), but also to erythrotoxic accumulation and aggregation of the β-globin-binding partner, α-globin (HBA1/2).
M. Cromer +22 more
semanticscholar +1 more source
The Prevention of Thalassemia [PDF]
Cold Spring Harbor Perspectives in Medicine, 2013 The thalassemias are among the most common inherited diseases worldwide, affecting individuals originating from the Mediterranean area, Middle East, Transcaucasia, Central Asia, Indian subcontinent, and Southeast Asia. As the diseases require long-term care, prevention of the homozygous state constitutes a major armament in the management. This article
Cao, Antonio, Kan, Yuet Wai
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Orphanet Journal of Rare Diseases, 2020 Background ß-thalassemia is one of the most common inherited blood disorders in the world and a major deterrent to the public health of Bangladesh. The management of thalassemia patients requires lifelong frequent blood transfusion and the available ...
F. A. Noor +13 more
semanticscholar +1 more source
Mediterranean Journal of Hematology and Infectious Diseases, 2019 Therapeutic advances, including the availability of oral iron chelators and new non-invasive methods for early detection and treatment of iron overload, have significantly improved the life expectancy and quality of life of patients with thalassemia, with a consequent increase in their reproductive potential and desire to have children.
Raffaella Origa, Federica Comitini
openaire +4 more sources