Results 201 to 210 of about 71,330 (251)
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Cardiac complications in thalassemia major
Annals of the New York Academy of Sciences, 2016The myocardium is particularly susceptible to complications from iron loading in thalassemia major. In the first years of life, severe anemia leads to high‐output cardiac failure and death if not treated. The necessary supportive blood transfusions create loading of iron that cannot be naturally excreted, and this iron accumulates within tissues ...
Auger, D, Pennell, DJ
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Pulmonary function in thalassemia major
The Journal of Pediatrics, 1987Pulmonary function tests were evaluated in 28 Chinese patients with beta-thalassemia major receiving regular transfusions and desferoxamine, and in 34 height-matched normal Chinese children. Comparison of lung function using analysis of covariance with reference to standing height showed that patients with thalassemia had a proportional decrease in ...
Fung, K.P. +3 more
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Psychosocial implications of Thalassemia Major
Pediatrics International, 2005Abstract Background : Many causes including the chronicity of disease, burden of treatment modalities, morbidities, and the expectation of early death resulting from the disease complications, may lead to psychosocial burden in Thalassemia Major (TM) patients.
Aydinok Y. +4 more
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Cardiovascular MRI in thalassemia major
Annals of the New York Academy of Sciences, 2010MRI assessment of myocardial iron and function has revolutionized the treatment of thalassemia major patients. While knowledge of somatic iron stores is vital for iron chelation management, it does not adequately monitor cardiac risk. MRI monitoring of cardiac T2* allows preclinical recognition of myocardial iron, stratifies prospective cardiac risk ...
John C, Wood, Leila, Noetzli
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Endocrine Function in Thalassemia Major
The Journal of Clinical Endocrinology & Metabolism, 1968Abstract Seven patients with thalassemia major, ranging in age from 6½ to 23 yr, were studied. Growth retardation was present in all except the youngest patient. Thyroid and adrenal function was normal. Three patients, however, showed an unexplained increase in the serum protein bound iodine level.
B, Kuo, E, Zaino, M S, Roginsky
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Complications of thalassemia major and their treatment
Expert Review of Hematology, 2011The life of patients with thalassemia has improved both in duration and in quality in industrialized countries. Complications are still common and include heart disease (heart failure and arrhythmias), chronic liver hepatitis, which can evolve in cirrhosis and, rarely, in hepatocellular carcinoma, endocrine problems (hypogonadism, hypothyroidism ...
BORGNA, Caterina, M. R. Gamberini
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Renal Enlargement in Thalassemia Major
Radiology, 1971Twenty-four patients with thalassemia major and no urinary tract complaints underwent excretory urography. The kidneys were large bilaterally in 17 patients; 2 other patients had enlargement of the left kidney. The autopsies of 13 patients were reviewed; the kidneys were large in all 13.
H, Grossman +3 more
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Iron Chelation in Thalassemia Major
Clinical Therapeutics, 2015Iron chelation has improved survival and quality of life of patients with thalassemia major. there are currently 3 commercially available iron-chelating drugs with different pharmacokinetic and pharmacodynamic activity. The choice of adequate chelation treatment should be tailored to patient needs and based on up-to-date scientific evidence.A review of
BORGNA, Caterina, Marsella, M.
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Auditory Involvement in Thalassemia Major
Acta Haematologica, 2009The auditory function of 75 children affected by homozygous β°-thalassemia, managed with a low transfusion scheme and treated irregularly with low doses of desferrioxamine, and of 75 controls were examined. In 12 patients a mild bilateral conductive hearing impairment due to bony hypertrophy and/or adenoid hypertrophy was found.
S, De Virgiliis +7 more
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Growth and Puberty in Thalassemia Major
Journal of Pediatric Endocrinology and Metabolism, 1995Growth and sexual development were evaluated in 54 (29 female, 25 male) patients with beta-thalassemia major aged 2.7-21.3 years (mean 10.4 yr). Mean pretransfusion hemoglobin concentration was 7.8 +/- 0.7 mg/dl. All patients except 6 were on desferrioxamine. Age of starting of therapy was 6.8 +/- 3.9 years.
N, Saka +5 more
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