Results 101 to 110 of about 5,799 (244)

Impact of multi-micronutrient fortified rice on hemoglobin, iron and vitamin A status of Cambodian schoolchildren : a double-blind cluster-randomized controlled trial [PDF]

, 2016
In Cambodia, micronutrient deficiencies remain a critical public health problem. Our objective was to evaluate the impact of multi-micronutrient fortified rice (MMFR) formulations, distributed through a World Food Program school-meals program (WFP-SMP ...
Berger, Jacques, Burja, K., Chamnan, C., Dijkhuizen, M.A., Fiorentino, Marion, Kuong, K., Parker, M., Perignon, Marlène, Wieringa, Franck   +8 more
core   +4 more sources

Medical haematology: Repositioning haematology at the centre of medicine

British Journal of Haematology, EarlyView.
The complementary domains of Medical Haematology and Haemato‐Oncology share a biological framework. The left panel depicts red cells, platelets, coagulation, thrombosis and innate immunity, while the right panel shows lymphoid and myeloid malignancies.
Cheng Hock Toh, Imelda Bates, Sue Pavord
wiley   +1 more source

EHA Research Roadmap on Hemoglobinopathies and Thalassemia: An Update

HemaSphere, 2019
. The inherited disorders of hemoglobin, which include sickle cell disease and thalassemias, are the most common and widespread distributed monogenic disorders.
Achille Iolascon, Lucia De Franceschi, Martina Muckenthaler, Ali Taher, David Rees, Mariane de Montalembert, Stefano Rivella, Androulla Eleftheriou, Maria Domenica Cappellini   +8 more
doaj   +1 more source

شيوع هموگلوبينوپاتی با توجه به ميزان انواع هموگلوبين و ارتباط آنها با حجم متوسط گلبول قرمز در بين دانش آموزان پيش‌دانشگاهی شهر بوشهر؛ 1386 [PDF]

, 2009
زمينه: هموگلوبينوپاتی ها از جمله تالاسمی و کم‎خونی داسی شکل از فراوان ترين اختلالات ژنتيکی در انسان می باشند. اين بيماری ها در حالت هتروزيگوت بدون علائم بالينی بوده ولی در حالت هموزيگوت نياز به خون و مراقبت های بيمارستانی دارند.
خمیسی پور, غلامرضا, عبیدی, نرگس, موحد, علی   +2 more
core  

Stroke burden and functional impacts in adults with sickle cell disease

British Journal of Haematology, EarlyView.
Stroke was identified in 4.6% of 454 adults with sickle cell disease. Stroke occurred not only across HbSS/Sβ0 phenotypes but also HbSC/Sβ+ as well, challenging traditional assumptions. Stroke was associated with long‐term functional impairment, including cognitive deficits and higher disability scores.
Jonathan St‐Onge, Tzvetena Hristova, Chrystelle Charles, Olena Bereznyakova, Gregory Jacquin, Olivier Pouliot, Janick Caron‐Lecuyer, Mia Stevanovik, Sara‐Maude Desforges, Costa M. Kazadi, Julian Alejandro Rivillas, Christian Stapf, Stéphanie Forté   +12 more
wiley   +1 more source

Establishment of MUi009 – A human induced pluripotent stem cells from a 32 year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2

Stem Cell Research, 2017
The thalassemias are a group of genetic disorders characterized by a deficiency in the synthesis of globin chains. In this study the MUi009-A human induced pluripotent stem cell line was successfully generated from peripheral blood CD34+ haematopoietic ...
Wasinee Wongkummool, Warun Maneepitasut, Pirut Tong-ngam, Amornrat Tangprasittipap, Thongperm Munkongdee, Chanikarn Boonchuay, Saovaros Svasti, Narisorn Kitiyanant, Kittiphong Paiboonsukwong, Suthat Fucharoen, Alisa Tubsuwan   +10 more
doaj   +1 more source

Making Advanced Therapies Affordable and Accessible: Two Strategic Approaches

Developing World Bioethics, EarlyView.
ABSTRACT This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create ‘valleys of death’ that prevent innovation from reaching ...
Ubaka Ogbogu, Lauren Albrecht
wiley   +1 more source

Whole Blood Transcriptomic Analysis of Sickle Cell Trait

European Journal of Haematology, EarlyView.
ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner   +12 more
wiley   +1 more source

Molecular Diagnostics of ß-Thalassemia

Balkan Journal of Medical Genetics, 2012
A high-quality hemoglobinopathy diagnosis is based on the results of a number of tests including assays for molecular identification of causative mutations.
Plaseska-Karanfilska Dijana, Atanasovska B, Bozhinovski G, Chakalova L, Kocheva S, Karanfilski O   +5 more
doaj   +1 more source

β-THALASSEMIA DISTRIBUTION IN THE OLD WORLD: A HISTORICAL STANDPOINT OF AN ANCIENT DISEASE

Mediterranean Journal of Hematology and Infectious Diseases, 2017
Background: Haemoglobinopathies constitute the commonest recessive monogenic disorders worldwide, and the treatment of affected individuals presents a substantial global disease burden.
Vincenzo De Sanctis
doaj   +1 more source