Results 41 to 50 of about 47,030 (243)
THALIDOMIDE AMELIORATES ERYTHROPOIESIS AND IRON HOMEOSTASIS IN TRANSFUSION-DEPENDENT β-THALASSEMIA
Mediterranean Journal of Hematology and Infectious DiseasesThalidomide is a therapeutic option for patients with β-thalassemia by increasing fetal hemoglobin and thereby reducing the requirement for blood transfusions.
Kun Yang, Jian Xiao
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Thalidomide attenuates the hyporesponsiveness of isolated atria to chronotropic stimulation in BDL rats: The involvement of TNF-α, IL-6 inhibition, and SOCS1 activation [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Cirrhotic cardiomyopathy is a complication of uncured cirrhosis which is associated with hyporesponsiveness of the heart to sympathetic stimulation. The enhancement of portal pressure, nitric oxide (NO) level, pro-inflammatory mediators and
Ali Hosseini-chegeni +5 more
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Advanced Intelligent Discovery, EarlyView.This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng +4 more
wiley +1 more source
Thalidomide surveillance and pharmacovigilance in Brazil – an overview
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2020 Introduction: The thalidomide is probably the best-known teratogenic drug and still results in cases of severe physical deformities in children born in Brazil.
Lisiane Freitas Leal +1 more
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Reversible Pulmonary Hypertension Related to Thalidomide Treatment for Multiple Myeloma
Case Reports in Oncology, 2011 Multiple myeloma (MM) is thrombogenic as a consequence of multiple hemostatic effects. Thalidomide is an effective treatment; however, it has been associated with an increased risk of thromboembolic events including pulmonary hypertension (PH). PH in the
Antonio Villa +4 more
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Safety of thalidomide and bevacizumab in patients with hereditary hemorrhagic telangiectasia
Orphanet Journal of Rare Diseases, 2019 BackgroundHereditary hemorrhagic telangiectasia (HHT) is a multisystemic inherited vascular dysplasia that leads to nosebleeds and visceral arteriovenous malformations (AVMs).
E. Buscarini +9 more
semanticscholar +1 more source
Scientific ReportsStudies of (S)-thalidomide were conducted on zebrafish embryos subjected to electroporation processes using a square wave pulse generator. The results showed that the electroporation increases the absorption of (S)-thalidomide through the chorion into ...
Anna Małkowska +7 more
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Thalidomide alleviated IgA nephropathy through “gut-kidney axis”
Linchuang shenzangbing zazhiObjective Thalidomide has anti-inflammatory, immunomodulatory and renoprotective effects. However, its study in IgA nephropathy has remained scarce. The aim was to explore the role and possible mechanism of thalidomide in IgA nephropathy.
Rui-hua Wang +3 more
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Haematologica, 2012 Background Thalidomide has potent antimyeloma activity, but no prospective, randomized controlled trial has evaluated thalidomide monotherapy in patients with relapsed/refractory multiple myeloma.Design and Methods We conducted an international ...
Martin Kropff +17 more
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Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease. [PDF]
PLoS ONE, 2013 Thalidomide is a tumor necrosis factor alpha (TNFα) inhibitor which has been found to have abilities against tumor growth, angiogenesis and inflammation.
Ping He +4 more
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