Results 41 to 50 of about 63,898 (235)
THALIDOMIDE AMELIORATES ERYTHROPOIESIS AND IRON HOMEOSTASIS IN TRANSFUSION-DEPENDENT β-THALASSEMIA
Mediterranean Journal of Hematology and Infectious DiseasesThalidomide is a therapeutic option for patients with β-thalassemia by increasing fetal hemoglobin and thereby reducing the requirement for blood transfusions.
Kun Yang, Jian Xiao
doaj +1 more source
Thalidomide induced impotence in male hematology patients: a common but ignored complication?
Haematologica, 2007 Thalidomide has become an important agent in the treatment of myeloma. However, thalidomide induced erectile dysfunction is a serious complication which has received very little attention. In our hematology department, 6 out of 11 male patients developed
Philip T. Murphy, John Rory O’Donnell
doaj +1 more source
Using serum CA125 to assess the activity of potential cytostatic agents in ovarian cancer [PDF]
, 2015 Objective: New strategies are required to rapidly identify novel cytostatic agents before embarking on large randomized trials. This study investigates whether a change in rate of rise (slope) of serum CA125 from before to after starting a novel agent ...
Ann Petruckevitch +21 more
core +1 more source
Thalidomide surveillance and pharmacovigilance in Brazil – an overview
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2020 Introduction: The thalidomide is probably the best-known teratogenic drug and still results in cases of severe physical deformities in children born in Brazil.
Lisiane Freitas Leal +1 more
doaj
Reversible Pulmonary Hypertension Related to Thalidomide Treatment for Multiple Myeloma
Case Reports in Oncology, 2011 Multiple myeloma (MM) is thrombogenic as a consequence of multiple hemostatic effects. Thalidomide is an effective treatment; however, it has been associated with an increased risk of thromboembolic events including pulmonary hypertension (PH). PH in the
Antonio Villa +4 more
doaj +1 more source
BMJ, 1994 EDITOR, - Use of thalidomide only on a named patient basis does not necessarily mean that patients are protected from its side effects, as implied by Baroness Cumberlege, the junior health minister.1 According to Sir William Asscher, the former chairman of the Committee on the Safety of Medicines, “the companies who supply a drug for named patient use ...
openaire +3 more sources
The effect of thalidomide on visceral fat pad mass and triglyceride concentration of the skeletal muscles in rats [PDF]
Yeungnam University Journal of Medicine, 2018 Background Body fats, especially both of abdominal fat pad mass and skeletal muscle fat content, are inversely related to insulin action. Therefore, methods for decreasing visceral fat mass and muscle triglyceride content may be helpful for the ...
Ki-Hoon Kim +2 more
doaj +1 more source
Thalidomide alleviated IgA nephropathy through “gut-kidney axis”
Linchuang shenzangbing zazhiObjective Thalidomide has anti-inflammatory, immunomodulatory and renoprotective effects. However, its study in IgA nephropathy has remained scarce. The aim was to explore the role and possible mechanism of thalidomide in IgA nephropathy.
Rui-hua Wang +3 more
doaj +1 more source
Canadian Journal of Gastroenterology and Hepatology, 2020 Objective. To observe the effects of thalidomide on 2,4,6-trinitrobenzenesulfonic acid- (TNBS-) induced experimental colitis in rats and to explore the possible mechanism of thalidomide in the treatment of CD. Methods.
Ying Xie +5 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear.
Jiang-Ming Chen +30 more
doaj +1 more source