Results 91 to 100 of about 45,377 (263)

Protodesnitazene: The identification and tissue distribution of a new nitazene

Journal of Forensic Sciences, EarlyView.
Abstract Multiple new analogues from the 2‐benzyl benzimidazole or “nitazene” class of drugs have emerged on the drug market in recent years. Nitazenes are highly potent μ‐opioid receptor agonists that present a substantial public health concern due to their elevated risk of severe toxicity in overdose and their significant potential for misuse.
Andrew Griffiths, Nathan Milne, Michelle Johnston, Karen Blakey, Rogan Scott   +4 more
wiley   +1 more source

GC/MS determination of gabapentin in human plasma and vitreous humor and its application to forensic samples

Journal of Forensic Sciences, EarlyView.
Abstract Gabapentin (GBP) is widely prescribed off‐label, and cases of misuse, abuse, self‐medication, and intentional self‐harm have been reported. This study aimed to develop and validate a simple GC‐MS method for the determination of GBP in plasma and vitreous humor (VH) and to explore the relationship between concentrations in both matrices in ...
Pamela Cabarcos‐Fernández, Inés Sánchez‐Sellero, Iván Álvarez‐Freire, María Jesús Tabernero‐Duque, Ana María Bermejo‐Barrera   +4 more
wiley   +1 more source

Vsebnost kanabinoidov v različnih fenotipih konoplje (Cannabis sativa L.) carmagnola selected in selekcije finola

Hmeljarski Bilten
Konoplja vsebuje zanjo specifične sekundarne metabolite kanabinoide, ki imajo veliko pozitivnih učinkov na zdravje ljudi in živali. Zaradi dvodomnosti in tujeprašnosti vrste ter populacijskih sort pogosto prihaja do pojava različnih fenotipov znotraj ...
Marjeta Eržen, Iztok Jože Košir, Miha Ocvirk, Samo Kreft, Andreja Čerenak   +4 more
doaj  

Estimating thresholds for risk of cannabis use disorder using standard delta‐9‐tetrahydrocannabinol (THC) units

Addiction, EarlyView.
Abstract Background and aims Lower risk guidelines for safer levels of cannabis use could help to reduce the health burden posed by cannabis use disorder (CUD). We aimed to estimate risk thresholds for CUD based on delta‐9‐tetrahydrocannabinol (THC) consumption using standard THC units (1 unit = 5 mg THC).
Rachel Lees Thorne, Will Lawn, Kat Petrilli, Katie Trinci, Anya Borissova, Shelan Ofori, Claire Mokrysz, H. Valerie Curran, Lindsey A. Hines, Tom P. Freeman   +9 more
wiley   +1 more source

Alcohol and cannabis use severity in relation to compulsive sexual behavior and problematic pornography use in a non-clinical sample: a cross-sectional study

Frontiers in Psychiatry
IntroductionCompulsive Sexual Behavior Disorder (CSBD) and problematic pornography use (PPU) frequently co-occur with substance use disorders, yet their associations with specific substances in non-clinical populations remain poorly understood.
Wiktoria Stasica, Alicja Anna Binkowska
doaj   +1 more source

Detecting cannabis use reduction through biochemical verification of urinary cannabinoids: An aggregated analysis of cannabis use disorder treatment trials examining average reductions and individual cut‐points

Addiction, EarlyView.
Abstract Background and aims Currently, there is no data‐driven cannabis reduction metric using biochemical verification, which represents a significant gap in cannabis harm reduction research, treatment and policy. Using aggregated data from 7 cannabis use disorder treatment trials, the aims of this analysis were to 1) determine if decreases in self ...
Erin A. McClure, Brian Neelon, Rachel L. Tomko, Ashley Dowd, Kevin M. Gray, Aimee L. McRae‐Clark, Nathaniel Baker   +6 more
wiley   +1 more source

Observational Analysis of the Influence of Medical Marijuana Use on Quality of Life in Patients

Medical Cannabis and Cannabinoids
Introduction: A significant gap exists in the understanding and utilization of medical marijuana and its effects on a patient’s quality of life. This is largely attributed to Cannabis’ sp.
Mark D. Kelley, Marwah Obaid, Edward M. Miller, Marla Bowie, Zachary S. Heeter   +4 more
doaj   +1 more source

Varenicline for cannabis use disorder: A randomized controlled trial

Addiction, EarlyView.
Abstract Background and aims Although cannabis use is widespread and prevalence of cannabis use disorder (CUD) is increasing, limited advancements have been made in CUD medication development. The objective of this study was to test the efficacy of varenicline with medical management for reducing cannabis use in treatment‐seeking individuals with CUD ...
Aimee L. McRae‐Clark, Kevin M. Gray, Nathaniel L. Baker, Brian J. Sherman, Bryan Tolliver, Jessica Burt, Alonzo Steplight, Elizabeth Chapman, Amanda Wagner   +8 more
wiley   +1 more source

Neurophysiological and Behavioural Effects of Combined Cannabis Concentrates and Alcohol Among People Who Regularly Use Alcohol and Cannabis. [PDF]

Addict Biol
This naturalistic feasibility study explored the effects of alcohol and cannabis co‐intoxication on behavioural performance and brain activity using electroencephalography. A performance monitoring task was administered three times over 4.5‐h at sober, intoxication, and recovery timepoints.
Hetelekides EM, Davies PL, Prince MA, Gavin WJ, Karoly HC.   +4 more
europepmc   +2 more sources

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source