Results 81 to 90 of about 45,377 (263)

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, and Cannabis

Frontiers in Pharmacology
BackgroundThe recent exponential increase in legalized medical and recreational cannabis, development of medical cannabis programs, and production of unregulated over-the-counter products (e.g., cannabidiol (CBD) oil, and delta-8-tetrahydrocannabinol ...
Rahul Nachnani, Amy Knehans, Jeffrey D. Neighbors, Paul T. Kocis, Paul T. Kocis, Tzuo Lee, Kayla Tegeler, Thomas Trite, Wesley M. Raup-Konsavage, Kent E. Vrana   +9 more
doaj   +1 more source

Alcohol and cannabinoids differentially affect HIV infection and function of human monocyte-derived dendritic cells (MDDC)

Frontiers in Microbiology, 2015
During human immunodeficiency virus (HIV) infection, alcohol has been known to induce inflammation while cannabinoids have been shown to have an anti-inflammatory role. For instance cannabinoids have been shown to reduce susceptibility to HIV-1 infection
Marisela eAgudelo, Gloria eFigueroa, Adriana eYndart, Gianna eCasteleiro, Karla eMuñoz, Thangavel eSamikkannu, Venkata Subba Rao Atluri, Madhavan P. Nair   +7 more
doaj   +1 more source

UK Medical Cannabis Registry: A Two-Year Prospective Observational Cohort Study of Clinical Outcomes in Insomnia. [PDF]

Neuropsychopharmacol Rep
Insomnia affects around one in ten adults. In this 2‐year UK Medical Cannabis Registry cohort study of 211 adults with insomnia, treatment with cannabis‐based medicinal products was associated with a sustained improvement in self‐reported sleep quality across 24 months.
Koye A, Erridge S, Clarke E, McLachlan K, Coomber R, Rucker JJ, Weatherall MW, Sodergren MH.   +7 more
europepmc   +2 more sources

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota, Jacy B. Parmera, Matheus Deltreggia, Pedro N. Martins, Anna Letícia M. Alves, Ananda C.M. de Falcone, Ana Rosa Santana, Maria Alice P. Falcão, Mayara A. Dias, Larissa I. Moreira, Paulo C. de Fonseca Filho, Eberval G. Figueiredo, Egberto R. Barbosa, Rubens G. Cury, Daniel C. de Andrade   +14 more
wiley   +1 more source

Cannabis and Health: Exploring Risks, Benefits and Research Horizons

Advances in Human Biology
Cannabis is the most widely used illicit substance globally, with its psychoactive compound, Delta-9-tetrahydrocannabinol (THC), exerting significant systemic effects. Upon consumption, tetrahydrocannabinol (THC) rapidly enters the bloodstream, affecting
Murali Punniakotti, Rahnuma Ahmad, James Villanueva, Tushar Roy, Keagan Mohammed, Dahiru Sani, Shegufta Mohammad, Manu Sundaram, Mainul Haque, Sayeeda Rahman   +9 more
doaj   +1 more source

Automated Magnetic Resonance Volumetry to Measure Multiple System Atrophy Disease Progression in Clinical Trials

Movement Disorders, EarlyView.
Abstract Background Recent studies have reported longitudinal brain atrophy in multiple system atrophy (MSA) in relatively small patient cohorts. Objective To compare longitudinal regional brain volume and clinical changes as endpoint measures for MSA clinical trials.
Andrea Quattrone, Ida Wilkens, Zeyu Zhu, Irfan A. Qureshi, Nicolai Franzmeier, Günter U. Höglinger, for the M‐STAR Study Group, Phillip Low, Wolfgang Singer, Stuart Isaacson, Susan Perlman, Tao Xie, Zbigniew Wszolek, Diana Kerwin, Diana Apateurova, Theresa Zesiewicz, Roy Freeman, Rajesh Pahwa, Nikolaus McFarland, Eric Molho, Michael Geschwind, Rajeev Kumar, Sana Aslam, Dignity Health, Jee Bang, Aaron Ellenbogen, Italo Biaggioni, Andres Deik, Patricio Millar Vernetti, Jose‐Alberto Palma‐Carazo, Horacio Kaufmann, Pravin Khemani, Jeremy Schmahmann, Xuemei Huang, Irene Litvan, Mitchell Miglis, Deborah Hall, Sheng‐Han Kuo, Stewart Factor, Steven Vernino, Werner Poewe, Caroline Thun‐Hohenstein, Sophie Drapier, Alexandre Eusebio, Wassilios Meissner, Anne Pavy Le Traon, Christine Tranchant, Daniela Berg, Jost‐Julian Rumpf, Karla Eggert, Alfons Schnitzler, Lars Tönges, Jens Ebentheuer, Claudia Trenkwalder, Inga Claus, Tobias Warnecke, Guenter Hoeglinger, Annika Spottke, Nicola Pavese, Alessio DiFonzo, Paolo Barone, Huw Morris, Klaus Seppi   +62 more
wiley   +1 more source

The potential global distribution of Drosophila suzukii, including consideration of irrigation and Australian host cropping areas

Pest Management Science, EarlyView.
This CLIMEX model of Drosophila suzukii fits the global distribution very well and includes irrigation effects. It indicates that D. suzukii could threaten all Australian berry and cherry production areas if introduced. Abstract BACKGROUND Spotted wing drosophila, Drosophila suzukii (Matsumura), is a major fruit fly pest of cherries and berries across ...
Jessica Mae Kriticos, Elle Saber, Eric Stone   +2 more
wiley   +1 more source

Efficacy and Safety of Cannabis Derivates and Their Synthetic Analogs. Overview of Systematic Reviews

Phytotherapy Research, EarlyView.
ABSTRACT The use of medicinal products derived from cannabis and its synthetic analogues has grown in recent years for various health conditions, which led to an increase in systematic reviews (SR) on the topic. The objective of this overview was to identify, synthesize, and critically appraise the evidence from SR on the benefits and harms of cannabis
Rafael Leite Pacheco, Daniela Fortunato Rêgo, Carolina de Oliveira Cruz Latorraca, Marco Aurelio de Carvalho Nascimento, André Bastos Daher, Rachel Riera   +5 more
wiley   +1 more source

Prevalence of novel psychoactive substances in selected clinical urine specimens submitted for drug monitoring

Journal of Forensic Sciences, EarlyView.
Abstract Novel psychoactive substances (NPS) are compounds emerging as alternatives to more established drugs of abuse. They are constantly changing and being modified, which makes their detection difficult. The study objective was to determine the prevalence of NPS in selected clinical specimens. Deidentified urine specimen remnants were analyzed that
Jillian R. Neifeld, Theresa M. Meli, Sarah H. Bartock   +2 more
wiley   +1 more source