Results 61 to 70 of about 45,377 (263)

Pharmacokinetics and Tolerability of Δ9-THC-Hemisuccinate in a Suppository Formulation as an Alternative to Capsules for the Systemic Delivery of Δ9-THC

open access: yesMedical Cannabis and Cannabinoids, 2018
The objectives of this study were: (1) to assess the safety, tolerability, and pharmacokinetics of ascending doses of Δ9-tetrahydrocannabinol-hemisuccinate (THC-HS) after rectal administration as suppositories in male volunteers; and (2) to ...
Mahmoud A. ElSohly   +2 more
doaj   +1 more source

Intoxicação por Cannabis sativa: Desafios relacionados à clínica de animais de companhia

open access: yesPubvet, 2020
As plantas do gênero Cannabis produzem, entre outros, uma classe de compostos químicos com relevante ação psicotrópica, os fitocanabinoides, por este motivo ela é a droga recreativa de maior consumo mundial.
Otávio Luiz Cardoso Rios   +4 more
doaj   +1 more source

Potential Contamination Cases in Anti‐Doping: Experiences and Practices of 33 Anti‐Doping Organisations

open access: yesDrug Testing and Analysis, EarlyView.
Across 33 Anti‐Doping Organisations (ADOs), 85% reported experiencing at least one contamination‐claim case in 2024–2025, but only 36% operate a standardised process for handling such claims. Dietary supplements were the leading alleged contamination source (76% of ADOs), followed by food (42%) and pharmaceutical products, intimate contact, and other ...
Kristian Slíž   +2 more
wiley   +1 more source

The Role of Nitrous Oxide (“Laughing Gas”) in DUID Cases and Its Impact on Driving Fitness

open access: yesDrug Testing and Analysis, EarlyView.
A total number of 39 cases of driving under the influence of nitrous oxide were investigated. Plasma concentrations of 0.22 to 17 mL/L (median:3.7 mL/L) were measured in blood samples withdrawn 38 to 144 min (median: 85 min) after control via Headspace‐GC–MS.
L. Lucuta   +4 more
wiley   +1 more source

Evaluación Experimental de los Efectos Agudos, Tolerancia Crónica y Especificidad Contextual de la Tolerancia al Cannabis en Indicadores Locomotores

open access: yesPsykhe, 2023
La evaluación experimental de la tolerancia al cannabis, entendida como el decremento en la respuesta a una cantidad específica de dicha droga luego de repetidas administraciones, ha carecido hasta el momento de una aproximación asociativa, centrándose ...
Felipe I. Varas   +9 more
doaj  

Carbon Anodes for Low‐Temperature Nonaqueous Alkali Metal‐Ion Batteries

open access: yesEcoEnergy, EarlyView.
This review summarizes recent progress in carbon anodes for low‐temperature nonaqueous alkali‐metal ion batteries. Fundamental thermodynamic and kinetic limitations are examined, alongside a systematic discussion of graphite, hard carbon, and emerging carbon architectures.
Zhichun Miao   +11 more
wiley   +1 more source

Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice.

open access: yesFrontiers in Cellular Neuroscience, 2013
Neuregulin 1 (NRG1) is linked to an increased risk of developing schizophrenia and cannabis dependence. Mice that are hypomorphic for Nrg1 (Nrg1 HET mice) display schizophrenia-relevant behavioural phenotypes and aberrant expression of serotonin and ...
Jarrah R Spencer   +14 more
doaj   +1 more source

Efficient Synthesis of Cannabinoid Acids

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
In this study, an alternative synthesis of cannabinoid acids was developed based on an O→C acyl rearrangement. Specifically, this strategy involved regioselective bromination followed by halogen–lithium exchange and intramolecular nucleophilic addition, which led to successful carboxylation.
Ryosuke Arai   +8 more
wiley   +1 more source

Medical Cannabis in Children

open access: yesRambam Maimonides Medical Journal, 2020
The use of medical cannabis in children is rapidly growing. While robust evidence currently exists only for pure cannabidiol (CBD) to treat specific types of refractory epilepsy, in most cases, artisanal strains of CBD-rich medical cannabis are being ...
Adi Aran, Dalit Cayam-Rand
doaj   +1 more source

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