Results 51 to 60 of about 42,998 (266)

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Electronic properties of ThC ⁻ and ThC

Physical Chemistry Chemical Physics
The low-lying electronic states, spin–orbit states, spectroscopic parameters, and energetics of ThC and ThC − are investigated using multireference and coupled-cluster theories.
openaire   +2 more sources

Eine kohlenstoffinduzierte Oberflächenrekonstruktion auf einem Fischer‐Tropsch‐Katalysator im Betrieb

Angewandte Chemie, EarlyView.
Nach einer weitverbreiteten Annahme erfährt der Cobalt‐basierte Fischer‐Tropsch‐Katalysator eine anfängliche Aufrauung, die zu einer Aktivitätssteigerung führt und vom hohen chemischen Potential des Kohlenstoffs getrieben wird. In der vorliegenden Operando‐STM‐ und DFT‐Untersuchung simulieren wir solche Bedingungen.
Sebastian Kläger, Sung Sakong, Axel Groß, Joost Wintterlin   +3 more
wiley   +1 more source

Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol

Arhiv za Higijenu Rada i Toksikologiju, 2020
Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of the cannabinoid receptor ligands is entirely CB1- or CB2-specific. The effects of cannabinoids therefore differ not just because
Černe Katarina
doaj   +1 more source

A Carbon‐Induced Surface Reconstruction on an Operating Fischer–Tropsch Catalyst

Angewandte Chemie International Edition, EarlyView.
It is widely believed that a cobalt Fischer–Tropsch catalyst initially undergoes an activity‐enhancing roughening, driven by the high chemical potential of carbon. In this operando STM and DFT study, we simulate such conditions. We show that, instead, a triangular stacking‐fault reconstruction may form, leaving the catalytic activity unchanged ...
Sebastian Kläger, Sung Sakong, Axel Groß, Joost Wintterlin   +3 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

SPE-GC-MS determination of THC, THC-OH and THC-COOH in urine samples

Arhiv za higijenu rada i toksikologiju, 2012
Cannabis is the most commonly used illicit drug in the world. Therefore, there is a great demand for reliable and sensitive methods for determining their presence in biological samples. Its use is detected by determining the presence of the main active compound Δ9-tetrahydrocannabinol (THC) and its metabolites 11-hydroxy-Δ9-tetrahydrocannabinol (THC-OH)
Nestić, Marina, Babić, Sandra, Mutavdžić Pavlović, Dragana, Sutlović, Davorka   +3 more
openaire   +2 more sources

Pharmacokinetics and Tolerability of Δ9-THC-Hemisuccinate in a Suppository Formulation as an Alternative to Capsules for the Systemic Delivery of Δ9-THC

Medical Cannabis and Cannabinoids, 2018
The objectives of this study were: (1) to assess the safety, tolerability, and pharmacokinetics of ascending doses of Δ9-tetrahydrocannabinol-hemisuccinate (THC-HS) after rectal administration as suppositories in male volunteers; and (2) to ...
Mahmoud A. ElSohly, Waseem Gul, Larry A. Walker   +2 more
doaj   +1 more source

Intoxicação por Cannabis sativa: Desafios relacionados à clínica de animais de companhia

Pubvet, 2020
As plantas do gênero Cannabis produzem, entre outros, uma classe de compostos químicos com relevante ação psicotrópica, os fitocanabinoides, por este motivo ela é a droga recreativa de maior consumo mundial.
Otávio Luiz Cardoso Rios, Kelmanny Crislen Ferreira Sousa, Thiago Barros Correia da Silva, Fernando Wiecheteck de Souza, Marcia Kikuyo Notomi   +4 more
doaj   +1 more source