Results 91 to 100 of about 149,069 (251)
Is DNA Damage Response Ready for Action Anywhere? [PDF]
, 2012 Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions.
Genescà, A. +4 more
core +4 more sources
Advanced Science, EarlyView.Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen +12 more
wiley +1 more source
Advanced Science, EarlyView.Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang +12 more
wiley +1 more source
Cancer Medicine, 2020 Background Defects in DNA damage repair (DDR) system may lead to genomic instability and manifest as increased immunogenicity. DDR deficiency is prevalent in ovarian cancer (OvCa); however, the association of DDR mutation with immune profiles in OvCa ...
Wenjuan Tian +13 more
doaj +1 more source
The relevance of schizotypal traits for understanding interpersonal functioning in adolescents with psychiatric problems. [PDF]
, 2017 A
De Clercq, Barbara +4 more
core +2 more sources
Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors
Advanced Science, EarlyView.Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu +11 more
wiley +1 more source
Frontiers in Oncology, 2019 Alterations in DNA damage response (DDR) is one of the several hallmarks of cancer. Genomic instability resulting from a disrupted DDR mechanism is known to contribute to cancer progression, and are subjected to radiation, cytotoxic, or more recently ...
Shaoli Das +2 more
doaj +1 more source
Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li +7 more
wiley +1 more source
One-dimensional Chern-Simons theory and the $\hat{A}$ genus
, 2013 We construct a Chern-Simons gauge theory for dg Lie and L-infinity algebras on any one-dimensional manifold and quantize this theory using the Batalin-Vilkovisky formalism and Costello's renormalization techniques.
Berline +17 more
core +1 more source
Energy Science &Engineering, EarlyView.Cuttings transport simulation workflow. ABSTRACT Efficient cuttings transport is essential for wellbore stability and minimizing non‐productive time in deviated and horizontal wells. This study applies global sensitivity analysis (GSA) to evaluate the influence of 14 drilling parameters on cuttings transport using WellPlanTM hydraulic simulations ...
Esraa A. Refaie +3 more
wiley +1 more source