Results 91 to 100 of about 30,219 (216)

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

Cancer Science, EarlyView.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut, Sébastien Martinez, Ludivine Pruvost, Louisane Eve, Rania El‐Botty, Laura Sourd, Elodie Montaudon, Ahmed Dahmani, Heloise Derrien, Stéphanie Sentis, Coralie Poulard, Elisabetta Marangoni, Olivier Trédan, Muriel Le Romancer   +13 more
wiley   +1 more source

Zeocin-induced DNA damage response in barley and its dependence on ATR

Scientific Reports
DNA damage response (DDR) is an essential mechanism by which living organisms maintain their genomic stability. In plants, DDR is important also for normal growth and yield.
Jovanka Vladejić, Martin Kovacik, Jana Zwyrtková, Miriam Szurman-Zubrzycka, Jaroslav Doležel, Ales Pecinka   +5 more
doaj   +1 more source

Effect of the Buccal Gap Width on Alveolar Process Reduction Following Immediate Implant Placement: A Retrospective CBCT Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To evaluate the effect of the width of the buccal gap on the alveolar process reduction after immediate implant placement (IIP) at maxillary central incisor sites, compared to contralateral pristine tooth sites. Material and Methods Twenty‐eight subjects who were treated with IIP to replace a maxillary central incisor and presented ...
Maurício G. Araújo, Debora R. Dias, Ping Wang, Robert A. Levine   +3 more
wiley   +1 more source

Cellular Morphometric Analysis (CellMorph)—a comprehensive imaging‐based tool for quantifying cellular phenotype heterogeneity and dynamics across biological processes

The FEBS Journal, EarlyView.
CellMorph is a groundbreaking tool that allows researchers to analyze multiple features from single cells, including cell size and shape, cytosolic staining and subcellular texture, nuclear staining, and morphometry. By evaluating images from both bright‐field and fluorescence microscopy, it also tracks changes in living cells during key processes such
Henrique Quaiato de Oliveira, Solon Andrades da Rosa, Luiza Cherobini Pereira, Laura Boose de Mendonça, Juliete Scholl, Fabrício Figueiró, Thais Cardoso Bitencourt, Davi Piovesan Echevarria, João Luiz Aldinucci Buzzo, Jessica Boschini D'Agostin, Danieli Rosane Dallemole, Carolina Oliveira, Fernanda Simas, Fernanda Saez‐Calazans, Débora Santos‐Sousa, Guido Lenz, Eduardo C. Filippi‐Chiela   +16 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition

Cell Reports
Summary: Sequencing of neuroblastoma (NB) tumors has revealed genetic alterations in genes involved in DNA damage response (DDR) pathways. However, roles for specific alterations of DDR genes in pediatric solid tumors remain poorly understood. To address
Madeline N. Hayes, Sarah Cohen-Gogo, Lynn Kee, Xueting Xiong, Alex Weiss, Mehdi Layeghifard, Yagnesh Ladumor, Ivette Valencia-Sama, Anisha Rajaselvam, David R. Kaplan, Anita Villani, Adam Shlien, Daniel A. Morgenstern, Meredith S. Irwin   +13 more
doaj   +1 more source

The Information Content of Operational Effectiveness

Journal of Business Finance &Accounting, EarlyView.
ABSTRACT We address whether and why a firm's operational effectiveness, OpEff$\textit{OpEff}$, has information content for investors and what role that information plays in the price discovery process at quarterly earnings announcements. We measure OpEff$\textit{OpEff}$ using the cash conversion cycle (CCC) multiplied by −1, such that higher OpEff ...
Mary E. Barth, Jonathan Berkovitch, Doron Israeli   +2 more
wiley   +1 more source

Root surface biomodification in periodontal therapy: Biological rationale and clinical applications

Periodontology 2000, EarlyView.
Abstract Regenerative periodontal therapy aims to form new cementum, periodontal ligament, and alveolar bone, all sealed by gingival tissue. The root surface acts as the wound margin during this regeneration process. Root surface biomodification (root conditioning/root decontamination), therefore, seems instrumental in promoting surface decontamination
Muhammad H. A. Saleh, Debora R. Dias, Andrea Ravida, Hom‐Lay Wang   +3 more
wiley   +1 more source

Due Diligence Regulation and Sustainability Governance in Value Chains: Lessons From the South African Wine Sector

Regulation &Governance, EarlyView.
ABSTRACT A recent raft of due diligence regulation (DDR) addressing social and environmental conditions in global value chains (GVCs) has spread across the UK and Europe. An emerging literature on DDR highlights the politics of its formation. Yet, we know little about how existing sustainability governance along GVCs interacts with DDR or the wider ...
Matthew Alford, Reena das Nair, Margareet Visser, Stefano Ponte, Shingie Chisoro   +4 more
wiley   +1 more source

Contestation and Compromise in Shaping the European Union's Corporate Sustainability due Diligence Directive: Implications for Global Value Chain Governance

Regulation &Governance, EarlyView.
ABSTRACT This paper explores the European Union's Corporate Sustainability Due Diligence Directive (CS3D) in the context of ongoing debates on private and public governance of global value chains (GVCs). Conceptually, it draws on neo‐Gramscian perspectives to analyze how contestation and compromise between distinct stakeholders and dynamics of hegemony
Louise Curran, Matthew Alford, Khalid Nadvi   +2 more
wiley   +1 more source