Results 111 to 120 of about 44,512 (277)

Anticoagulant Rodenticides Contribute to a Decline in an Urban Carnivore

Animal Conservation, EarlyView.
Anticoagulant rodenticides (ARs) have been shown to negatively affect carnivores globally and are closely tied to human activity and development. We examined drivers of annual survival in bobcats persisting on a residentially developed barrier island over 16 years.
Meghan P. Keating, Catherine M. Bodinof Jachowski, Duane R. Diefenbach, James D. Jordan, Nicole M. Nemeth, Thomas R. Rainwater, Gregory K. Yarrow, David S. Jachowski   +7 more
wiley   +1 more source

Advancing cancer therapy: new frontiers in targeting DNA damage response

Frontiers in Pharmacology
Genomic instability is a core characteristic of cancer, often stemming from defects in DNA damage response (DDR) or increased replication stress. DDR defects can lead to significant genetic alterations, including changes in gene copy numbers, gene ...
Jiekun Qian, Jiekun Qian, Guoliang Liao, Guoliang Liao, Maohui Chen, Maohui Chen, Ren-Wang Peng, Xin Yan, Jianting Du, Jianting Du, Renjie Huang, Renjie Huang, Maojie Pan, Maojie Pan, Yuxing Lin, Yuxing Lin, Xian Gong, Xian Gong, Guobing Xu, Guobing Xu, Bin Zheng, Bin Zheng, Chun Chen, Chun Chen, Zhang Yang, Zhang Yang   +25 more
doaj   +1 more source

Sofortresonanzen DDR Fernsehen 8. Woche 1989 (SFR 8/89)

, 2011
Zuschauerbeteiligung und Fernsehverhalten. Themen: Sehbeteiligung und Bewertung der Sendungen in der Woche vor der Befragung; Zusatzfragen: Unterhaltungs- und Realitätsgehalt des Films POLIZEIRUF 110: VARIANTE TRAMPER und Gefallen der Schauspieler ...
Staatliches Komitee f\ufcr Fernsehen beim Ministerrat der DDR, Abteilung Soziologische Forschung, Berlin
core   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Anti-tumor effects of the eIF4A inhibitor didesmethylrocaglamide and its derivatives in human and canine osteosarcomas

Scientific Reports
Inhibition of translation initiation using eIF4A inhibitors like (−)-didesmethylrocaglamide [(−)-DDR] and (−)-rocaglamide [(−)-Roc] is a potential cancer treatment strategy as they simultaneously diminish multiple oncogenic drivers.
Janet L. Oblinger, Jack Wang, Georgia D. Wetherell, Garima Agarwal, Tyler A. Wilson, Nicole R. Benson, Joelle M. Fenger, James R. Fuchs, A. Douglas Kinghorn, Long-Sheng Chang   +9 more
doaj   +1 more source

Sofortresonanzen DDR Fernsehen 51. Woche 1989 (SFR 51/89)

, 2011
Zuschauerbeteiligung und Fernsehverhalten. Themen: Sehbeteiligung und Bewertung der Sendungen in der Woche vor der Befragung; Zusatzfragen: Bewertung der Sendung AUSSENSEITER – SPITZENREITER; Gesamteindruck von dem Film DIE GESTUNDETE ZEIT; Gefallen der
Staatliches Komitee f\ufcr Fernsehen beim Ministerrat der DDR, Abteilung Soziologische Forschung, Berlin
core   +1 more source

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

Cancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah, Mackenzie M. Mayhew, Jacob Sellers, Russell G. Witt   +3 more
wiley   +1 more source

Sofortresonanzen DDR Fernsehen 2. Woche 1988 (SFR 2/88)

, 2011
Zuschauerbeteiligung und Fernsehverhalten. Themen: Sehbeteiligung und Bewertung der Sendungen in der Woche vor der Befragung; Zusatzfragen: Meinung zur Sendung DER VOGEL; Rezeption der Sendereihe COMPUTERSTUNDE; Zufriedenheit mit der Sendung ...
Staatliches Komitee f\ufcr Fernsehen beim Ministerrat der DDR, Abteilung Soziologische Forschung, Berlin
core   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

From Combat to Community: a Study of how Community-based Approach to Disarmament, Demobilisation, and Reintegration (DDR) can Contribute More Effectively to Peacebuilding: The Case of Sierra Leone [PDF]

, 2010
The disarmament, demobilization and reintegration (DDR) of ex-combatants is one of the vital elements of peacebuilding with the objective of reconciling ex-combatants into communities and reducing the likelihood of renewed violence.
Asiedu, Victor Odame
core