Results 111 to 120 of about 150,892 (276)

Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley   +1 more source

Terrell‐Penrose‐Effekt erstmals im Labor demonstriert: Ein Augenblick bei Lichtgeschwindigkeit

Physik in unserer Zeit, EarlyView.
Der Terrell‐Penrose‐Effekt beschreibt, wie ein Objekt erscheint, das sich gegenüber einem Beobachter relativistisch schnell bewegt. Ist die Lorentz‐Kontraktion sichtbar? Wegen der Zeitverzögerung der unterschiedlich langen Lichtwege von der Oberfläche des Objekts sollte es auf besondere Weise verformt erscheinen.
Philipp Haslinger, Dominik Hornof, Enar de Dios Rodríguez, Peter Schattschneider   +3 more
wiley   +1 more source

Extracellular vesicles transfer nuclear Abl-dependent and radiation-induced miR-34c into unirradiated cells to cause bystander effects. [PDF]

, 2018
Ionizing radiation (IR) not only activates DNA damage response (DDR) in irradiated cells but also induces bystander effects (BE) in cells not directly targeted by radiation.
Chan, Josolyn, Hwang, Amini, Rastogi, Shubhra, Wang, Jean YJ   +3 more
core  

The clashing of in situ and pre‐cast technologies—Western trends and local traditions in concrete engineering shaping shell construction in 20th‐century Hungary

Structural Concrete, EarlyView.
Abstract After a blossoming pre‐World War II (WWII) period, the concrete construction industry in then‐socialist Hungary existed in a relative isolation from the Western World during the mid‐20th century. In this paper, we focus on the body of work of one of the then newly established state‐owned design offices, IPARTERV, to show how the isolation ...
Orsolya Gáspár, Péter Haba
wiley   +1 more source

Advancing cancer therapy: new frontiers in targeting DNA damage response

Frontiers in Pharmacology
Genomic instability is a core characteristic of cancer, often stemming from defects in DNA damage response (DDR) or increased replication stress. DDR defects can lead to significant genetic alterations, including changes in gene copy numbers, gene ...
Jiekun Qian, Jiekun Qian, Guoliang Liao, Guoliang Liao, Maohui Chen, Maohui Chen, Ren-Wang Peng, Xin Yan, Jianting Du, Jianting Du, Renjie Huang, Renjie Huang, Maojie Pan, Maojie Pan, Yuxing Lin, Yuxing Lin, Xian Gong, Xian Gong, Guobing Xu, Guobing Xu, Bin Zheng, Bin Zheng, Chun Chen, Chun Chen, Zhang Yang, Zhang Yang   +25 more
doaj   +1 more source

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling

Viruses, 2017
Human papillomaviruses (HPV) require the activation of the DNA damage response (DDR) in order to undergo a successful life cycle. This activation presents a challenge for the virus and the infected cell: how does viral and host replication proceed in the
Molly L. Bristol, Dipon Das, Iain M. Morgan   +2 more
doaj   +1 more source

Derived stacks in symplectic geometry

, 2018
This is a survey paper on derived symplectic geometry, that will appear as a chapter contribution to the book "New Spaces for Mathematics and Physics", edited by Mathieu Anel and Gabriel Catren.
Calaque, Damien
core   +3 more sources

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

The Wind of Change: Mapping Wind Energy Growth and Multi‐Species Vulnerability in Sardinia, Mediterranean

Animal Conservation, EarlyView.
The rapid expansion of wind energy across the Mediterranean region calls for more advanced tools to assess and mitigate its impacts on biodiversity. In this study, we present an innovative approach combining 13‐year satellite imagery analysis and ecological modelling, to assess the spatiotemporal overlap between wind energy development and habitat ...
Chiara Costantino, Jacopo Cerri, Ilaria Fozzi, Davide De Rosa, Fiammetta Berlinguer   +4 more
wiley   +1 more source

Anticoagulant Rodenticides Contribute to a Decline in an Urban Carnivore

Animal Conservation, EarlyView.
Anticoagulant rodenticides (ARs) have been shown to negatively affect carnivores globally and are closely tied to human activity and development. We examined drivers of annual survival in bobcats persisting on a residentially developed barrier island over 16 years.
Meghan P. Keating, Catherine M. Bodinof Jachowski, Duane R. Diefenbach, James D. Jordan, Nicole M. Nemeth, Thomas R. Rainwater, Gregory K. Yarrow, David S. Jachowski   +7 more
wiley   +1 more source