Results 91 to 100 of about 150,892 (276)
Advanced Science, EarlyView.Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo +20 more
wiley +1 more source
Cancer Medicine, 2020 Background Defects in DNA damage repair (DDR) system may lead to genomic instability and manifest as increased immunogenicity. DDR deficiency is prevalent in ovarian cancer (OvCa); however, the association of DDR mutation with immune profiles in OvCa ...
Wenjuan Tian +13 more
doaj +1 more source
Fluid Dynamical Profiles and Constants of Motion from d-Branes [PDF]
, 1999 Various fluid mechanical systems enjoy a hidden, higher-dimensional dynamical Poincare symmetry, which arises owing to their descent from a Nambu-Goto action.
Jackiw, R., Polychronakos, A. P.
core +4 more sources
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source
Genes and DiseasesDNA damage repair (DDR) genes play critical roles in maintaining genome stability. However, they are prone to genetic variation, of which pathogenic variation (PV) is a predisposing factor for high risk of cancer development in modern humans. Knowing the
Jiaheng Li +11 more
doaj +1 more source
Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
The way the definite determiner affects quantifiers in Basque [PDF]
, 2012 Based on Basque data (and in line with Etxeberria & Giannakidou 2010, to appear), this paper argues that the domain for quantifiers in certain languages is restricted overtly by a definite determiner (D).
Etxeberria, Urtzi
core +2 more sources
Advanced Science, EarlyView.This study achieves the synergistic integration of self‐powered sensing and edge AI acceleration to establish a real‐time fault diagnosis system. The proposed TENG‐based self‐powered bearing sensor (NSE‐TBS) and FPGA‐accelerated edge AI framework fundamentally break through the inherent limitations of conventional monitoring systems, including complex ...
Kehui Zhu +7 more
wiley +1 more source
Trust and glycemic control in black patients with diabetic retinopathy: A pilot study [PDF]
, 2019 Diabetic retinopathy (DR) is more prevalent in blacks than whites because, compared to whites, blacks on average have worse glycemic control. Both of these racial disparities reflect differences in sociocultural determinants of health, including ...
Casten, Robin J., Rovner, Barry W.
core +1 more source
Hopf-cyclic cohomology of the Connes-Moscovici Hopf algebras with infinite dimensional coefficients
, 2017 We discuss a new strategy for the computation of the Hopf-cyclic cohomology of the Connes-Moscovici Hopf algebra $\mathcal{H}_n$. More precisely, we introduce a multiplicative structure on the Hopf-cyclic complex of $\mathcal{H}_n$, and we show that the ...
Aliabadi, F. Yazdani +2 more
core +1 more source