Results 101 to 110 of about 173,239 (326)

Galactic Chemical Evolution Models Favor an Extended Type Ia Supernova Delay-time Distribution

The Astrophysical Journal
Type Ia supernovae (SNe Ia) produce most of the Fe-peak elements in the Universe and therefore are a crucial ingredient in galactic chemical evolution models.
Liam O. Dubay, Jennifer A. Johnson, James W. Johnson   +2 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

He Awa Whiria: The Tidal Streams of Interstellar Objects

The Astrophysical Journal
Upcoming surveys are likely to discover a new sample of interstellar objects (ISOs) within the solar system, but questions remain about the origin and distribution of this population within the Galaxy.
John C. Forbes, Michele T. Bannister, Chris Lintott, Angus Forrest, Simon Portegies Zwart, Rosemary C. Dorsey, Leah Albrow, Matthew J. Hopkins   +7 more
doaj   +1 more source

The Circular Velocity Curve of the Milky Way from 5 to 25 kpc [PDF]

Astrophysical Journal, 2018
We measure the circular velocity curve vc(R) of the Milky Way with the highest precision to date across Galactocentric distances of 5 ≤ R ≤ 25 kpc. Our analysis draws on the six-dimensional phase-space coordinates of ≳23,000 luminous red giant stars, for
A. Eilers, D. Hogg, H. Rix, M. Ness
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Milky Way Is a Less Massive Galaxy—New Estimates of the Milky Way’s Local and Global Stellar Masses

The Astrophysical Journal Letters
Stellar mass is the most fundamental property of a galaxy. While it has been robustly measured for millions of external galaxies, it remains poorly constrained for the Milky Way because of the strong selection effect from our inside perspective.
Jianhui Lian, Tao Wang, Qikang Feng, Yang Huang, Helong Guo   +4 more
doaj   +1 more source

The incorrect rotation curve of the Milky Way

, 2015
In the fundamental quest of the rotation curve of the Milky Way, the tangent-point (TP) method has long been the simplest way to infer velocities for the inner, low latitude regions of the Galactic disk from observations of the gas component. We test the
Chemin, Laurent, Renaud, Florent, Soubiran, Caroline   +2 more
core   +3 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Milky Way disk

, 2015
This review summarises the invited presentation I gave on the Milky Way disc. The idea underneath was to touch those topics that can be considered hot nowadays in the Galactic disk research: the reality of the thick disk, the spiral structure of the ...
Carraro, Giovanni
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source