Results 41 to 50 of about 154,036 (328)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Estimating the Initial Mass of the Gaia–Enceladus Dwarf Galaxy with a Chemical Evolution Model
The Astrophysical JournalThis work investigates the initial mass and chemical evolution history of the Gaia–Enceladus dwarf galaxy. We combine spectroscopic data from APOGEE with astrometric data from Gaia Data Release 3 to identify Gaia–Enceladus candidate stars via a machine ...
Olcay Plevne, Furkan Akbaba
doaj +1 more source
Simulating the Milky Way is hard
EPJ Web of Conferences, 2012 The formation of the Milky Way in the currently accepted concordance cosmology presents a couple of pitfalls. Mostly, these involve the much reported overcooling problem.
Stinson G., Brook C.
doaj +1 more source
The Formalism of Milky-Way Antimatter-Domains Evolution
Galaxies, 2023 If baryosynthesis is strongly nonhomogeneous, macroscopic regions with antibaryon excess can be created in the same process from which the baryonic matter is originated. This exotic possibility can become real, if the hints to the existence of antihelium
Maxim Yu. Khlopov, Orchidea Maria Lecian
doaj +1 more source
This chapter reviews the three-dimensional structure, age, kinematics, and chemistry of the Milky Way (MW) region within ~2 kpc from its center (hereafter referred to as the 'bulge') from an observational perspective. While not exhaustive in citations, this review provides historical context and discusses the main controversies and limitations in the ...
Zoccali, Manuela, Valenti, Elena
openaire +2 more sources
Diffuse Ionized Gas in the Milky Way Disk [PDF]
, 2017 We analyze the diffuse ionized gas (DIG) in the first Galactic quadrant from l=18deg to 40deg using radio recombination line (RRL) data from the Green Bank Telescope. These data allow us to distinguish DIG emission from HII region emission and thus study
Anderson, L. D. +4 more
core +3 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
What Is Missing from the Local Stellar Halo?
The Astrophysical JournalThe Milky Way’s stellar halo, which extends to >100 kpc, encodes the evolutionary history of our Galaxy. However, most studies of the halo to date have been limited to within a few kiloparsecs of the Sun.
Katherine Sharpe +2 more
doaj +1 more source
Rotation curve of the Milky Way
EPJ Web of Conferences, 2012 We use SEGUE and Hipparcos data to restrict the behaviour of the rotation curve of the Milky Way in the solar neighbourhood. Then we construct a density model of the Milky Way which best reproduces the available observations of the rotation curve and is ...
Lee Y.S. +3 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source