Results 71 to 80 of about 154,036 (328)
Insight Into the Formation of the Milky Way Through Cold Halo Substructure. I. The ECHOS of Milky Way Formation [PDF]
, 2009 We identify ten -- seven for the first time -- elements of cold halo substructure (ECHOS) in the volume within 17.5 kpc of the Sun in the inner halo of the Milky Way.
Abadi +98 more
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Milky Way and other spiral galaxies
EPJ Web of Conferences, 2012 Cosmologists have often considered the Milky Way as a typical spiral galaxy, and its properties have considerably influenced the current scheme of galaxy formation.
Wang J.L. +5 more
doaj +1 more source
, 2015 This review summarises the invited presentation I gave on the Milky Way disc. The idea underneath was to touch those topics that can be considered hot nowadays in the Galactic disk research: the reality of the thick disk, the spiral structure of the ...
Carraro, Giovanni
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Gaussian Process Methods for Very Large Astrometric Data Sets
The Astrophysical JournalWe present a novel nonparametric method for inferring smooth models of the mean velocity field and velocity dispersion tensor of the Milky Way from astrometric data.
Timothy Hapitas +3 more
doaj +1 more source
Lessons from the Milky Way: the Kapteyn Universe
, 2014 Jacobus Cornelius Kapteyn (1851-1922) presented a model for the distribution of stars in space together with a dynamical interpretation in terms of an equilibrium between the gravitational field of the stars and their random motion and rotation.
van der Kruit, P. C.
core +1 more source
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
On the Formation of Planets in the Milky Way’s Thick Disk
The Astrophysical JournalExoplanet demographic surveys have revealed that close-in (≲1 au) small planets orbiting stars in the Milky Way’s thick disk are ∼50% less abundant than those orbiting stars in the Galactic thin disk.
Tim Hallatt, Eve J. Lee
doaj +1 more source
Dynamical Models for the Milky Way
, 1996 The only way to map the Galaxy's gravitational potential $\Phi({\bf x})$ and the distribution of matter that produces it is by modelling the dynamics of stars and gas. Observations of the kinematics of gas provide key information about gradients of $\Phi$
Binney, James, Dehnen, Walter
core