Results 61 to 70 of about 5,021 (275)

A Systematic Review on Main Chemical Constituents of Papaver bracteatum

open access: yesJournal of Medicinal Plants, 2015
Papaver bracteatum Lindly (Papaveraceae) is an endemic species of Iran which has economic importance in drug industries. The main alkaloid of the plant is thebaine which is used as a precursor of the semi-synthetic and synthetic compounds including ...
M Soleymankhani   +5 more
doaj  

Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway.

open access: yesJournal of Structural Biology, 2018
Thebaine 6-O-demethylase (T6ODM) from Papaver somniferum (opium poppy), which belongs to the non-heme 2-oxoglutarate/Fe(II)-dependent dioxygenases (ODD) family, is a key enzyme in the morphine biosynthesis pathway.
A. Kluza   +7 more
semanticscholar   +2 more sources

Endophytic Consortium With Diverse Gene-Regulating Capabilities of Benzylisoquinoline Alkaloids Biosynthetic Pathway Can Enhance Endogenous Morphine Biosynthesis in Papaver somniferum

open access: yesFrontiers in Microbiology, 2019
Secondary metabolite biosynthesis in medicinal plants is multi-step cascade known to be modulated by associated endophytes. While a single endophyte is not able to upregulate all biosynthetic steps, limiting maximum yield achievement.
Tania Ray   +5 more
doaj   +1 more source

A novel plasmid‐based experimental system in Saccharomyces cerevisiae that enables the introduction of 10 different plasmids into cells

open access: yesFEBS Open Bio, Volume 14, Issue 12, Page 1955-1971, December 2024.
We developed the Saccharomyces cerevisiae strains termed Δ10 that exhibit auxotrophic behavior for 10 different nutrients and the plasmids with auxotrophic markers for use in Δ10 strains. Δ10 strains were able to maintain 10 types of plasmids by auxotrophic selection.
Geyao Dong   +2 more
wiley   +1 more source

Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

open access: yesNature Communications, 2016
Opiates—the gold standard for pain relief—are currently produced by extraction from opium poppies. Here the authors show that bacteria can serve as an efficient and flexible platform for the production of opiates by demonstrating the total synthesis of ...
Akira Nakagawa   +9 more
doaj   +1 more source

In Vitro Polyploidy Induction in Persian Poppy (Papaver bracteatum Lindl.)

open access: yesCaryologia, 2020
Papaver bracteatum Lindl. grows as a wild perennial medicinal plant in Northern Iran and is known mainly for its high amounts of the pharmaceutically valuable alkaloid of thebaine. In vitro production of tetraploid P.
Saeed Tarkesh Esfahani   +2 more
doaj   +1 more source

Structural analysis of a ligand‐triggered intermolecular disulfide switch in a major latex protein from opium poppy

open access: yesActa Crystallographica Section D, Volume 80, Issue 9, Page 675-685, September 2024.
Crystal structures of two cysteine‐to‐serine mutants of PR10‐10 help to reveal how a ligand‐induced conformational change is coupled to the formation of intermolecular disulfide bonds in plant pathogenesis‐related family 10 proteins involved in the biosynthesis of benzylisoquinoline alkaloids.Several proteins from plant pathogenesis‐related family 10 ...
Samuel C. Carr   +2 more
wiley   +1 more source

Strangers in a foreign land: ‘Yeastizing’ plant enzymes

open access: yesMicrobial Biotechnology, Volume 17, Issue 9, September 2024.
Many plant secondary metabolic enzymes need to be re‐engineered for optimal performance in yeast platforms due to poor adaptation to the foreign cellular environment. We highlight the challenges in ‘yeastizing’ plant enzymes and propose a data‐driven framework for learning the yeastizing rules from natural protein sequence variations.
Kristen Van Gelder   +3 more
wiley   +1 more source

The Effect of L-tyrosine on Thebaine Production in Cell Suspension Culture of Iranian Poppy (Papaver bracteatum)

open access: yesJournal of Medicinal Plants, 2016
Background: Using of elicitors and different compounds in cell suspension culture is an effective strategy for enhancement and improvement of important secondary metabolites production in in vitro conditions.
R Farjaminezhad   +3 more
doaj  

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