Results 21 to 30 of about 8,099 (198)

A New Anticancer Semisynthetic Theobromine Derivative Targeting EGFR Protein: CADDD Study

open access: yesLife, 2023
A new lead compound has been designed as an antiangiogenic EGFR inhibitor that has the pharmacophoric characteristics to bind with the catalytic pocket of EGFR protein.
I. Eissa   +8 more
semanticscholar   +1 more source

Evaluation of theobromine content and the relationship between cocoa percentages in dark chocolates

open access: yesFunctional Foods in Health and Disease, 2023
Background: There are no specific regulations governing the labeling of dark chocolate or its bioactive component quantities.. The main alkaloid of the cocoa bean is theobromine. Chocolate is by far the main source of theobromine in the Western diet.
Fatma Hulyam Eren, S. Kabaran
semanticscholar   +1 more source

Efficacy of Theobromine and Its Metabolites in Reducing the Risk of Uric Acid Lithiasis

open access: yesInternational Journal of Molecular Sciences, 2023
Uric acid lithiasis accounts for about 10% of all types of renal lithiasis. The most common causes of uric acid lithiasis are low urinary pH, followed by high concentration of urinary uric acid, and low diuresis.
A. Costa-Bauzà   +3 more
semanticscholar   +1 more source

One-way or two-way sweet link between theobromine and depression?

open access: yesBMC Psychiatry, 2023
Theobromine is an abundant methylxanthine in cocoa/chocolate. A recent article in BMC Psychiatry concludes that theobromine consumption increases the risk of depression. In our opinion, it is difficult to make a correlation between dietary habits and the
Rafael Franco, Eva Martínez-Pinilla
doaj   +1 more source

Artificial Caries Lesion Characteristics after Secondary Demineralization with Theobromine-Containing Protocol

open access: yesMolecules, 2021
Developing artificial caries lesions with varying characteristics is needed to adequately study caries process in vitro. The objective of this study was to investigate artificial caries lesion characteristics after secondary demineralization protocol ...
Hani M. Nassar, Frank Lippert
doaj   +1 more source

A New Theobromine-Based EGFRWT and EGFRT790M Inhibitor and Apoptosis Inducer: Design, Semi-Synthesis, Docking, DFT, MD Simulations, and In Vitro Studies

open access: yesProcesses, 2022
The essential pharmacophoric structural properties were applied to design a new derivative of theobromine as an antiangiogenic EGFR inhibitor. The designed candidate is a (para-nitrophenyl)acetamide derivative of the natural alkaloid, theobromine (T-2 ...
E. Elkaeed   +9 more
semanticscholar   +1 more source

Caffeine, Paraxanthine, Theophylline, and Theobromine Content in Human Milk

open access: yesNutrients, 2022
This study aimed to assess the content of caffeine and its metabolites—paraxanthine, theophylline, and theobromine—in breast milk according to selected factors.
Aleksandra Purkiewicz   +3 more
semanticscholar   +1 more source

Temperature Effect of the Theobromine’s Electronic and Antioxidant Properties

open access: yesInternational Journal of Secondary Metabolite, 2019
Theobromine exists in cocoa, which has an antioxidant ingredient. It is also affect our nervous system. For this reason, it’s very important to know the properties of the theobromine.
Aslı Öztürk Kiraz
doaj   +1 more source

Uses of mid-infrared spectroscopy and chemometric models for differentiating between dried cocoa bean varieties [PDF]

open access: yesRevista Brasileira de Engenharia Agrícola e Ambiental, 2023
Generally, the taxonomic classification of cocoa beans is based on the theobromine/caffeine ratio determined using high-performance liquid chromatography (HPLC). However, this technique involves laborious and time-consuming calculations. Attenuated total
Gentil A. Collazos-Escobar   +3 more
doaj   +1 more source

Theobromine Effects on Enamel Surface Microhardness: In Vitro

open access: yesJournal of Dentistry Indonesia, 2013
Dental caries is still a dental health problem in Indonesia. Fluoride, one of the dental caries prevention material, but its safety and the danger of fluorosis is still debated. Theobromine is an alkaloid compound contained in cocoa beans. Theobromine is
Grace Syafira   +2 more
doaj   +1 more source

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