Results 101 to 110 of about 3,300,951 (351)

A Potent Micron Neoantigen Tumor Vaccine GP‐Neoantigen Induces Robust Antitumor Activity in Multiple Tumor Models

Advanced Science, 2022
Therapeutic tumor neoantigen vaccines have been widely studied given their good safety profile and ability to avoid central thymic tolerance. However, targeting antigen‐presenting cells (APCs) and inducing robust neoantigen‐specific cellular immunity ...
Zhe Jing, Shuqing Wang, Keyuan Xu, Qian Tang, Wenjing Li, Wei Zheng, Haobo Shi, Kailing Su, Yanting Liu, Zhangyong Hong   +9 more
doaj   +1 more source

Therapeutic vaccination against HIV

Expert Review of Vaccines, 2004
The challenge for an immunotherapeutic vaccine is to increase antiviral responses in an increasingly immunocompromised host and to provide immunity to epitopes that have been neglected by the infected host. Therapeutic vaccination with structural and regulatory genes and proteins of HIV are reviewed. The most promising clinical results consist of short-
Britta, Wahren, Margaret, Liu
openaire   +2 more sources

Phase I clinical trial of an intranodally administered mRNA-based therapeutic vaccine against HIV-1 infection

AIDS (London), 2018
Objective: The efficacy of therapeutic vaccines against HIV-1 infection has been modest. New inerts to redirect responses to vulnerable sites are urgently needed to improve these results.
L. Leal, A. Guardo, S. Morón-López, M. Salgado, B. Mothe, C. Heirman, P. Pannus, G. Vanham, H. van den Ham, R. Gruters, A. Andeweg, S. van Meirvenne, J. Pich, J. Arnaiz, J. Gatell, C. Brander, K. Thielemans, J. Martinez-Picado, M. Plana, Felipe García   +19 more
semanticscholar   +1 more source

Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow, Nicola McKern, Vincent Oxenham, Kate Ahmad, Omar Ahmad   +4 more
wiley   +1 more source

Safety Profile of a Virus-Like Particle-Based Vaccine Targeting Self-Protein Interleukin-5 in Horses

Vaccines, 2020
Background: Insect bite hypersensitivity (IBH) is an eosinophilic allergic dermatitis of horses caused by type I/IVb reactions against mainly Culicoides bites.
Sigridur Jonsdottir, Victoria Fettelschoss, Florian Olomski, Stephanie C. Talker, Jelena Mirkovitch, Tanya Rhiner, Katharina Birkmann, Franziska Thoms, Bettina Wagner, Martin F. Bachmann, Thomas M. Kündig, Eliane Marti, Antonia Fettelschoss-Gabriel   +12 more
doaj   +1 more source

Five-year Follow-up of Chronic Hepatitis B Patients Immunized by Nasal Route with the Therapeutic Vaccine HeberNasvac

Euroasian Journal of Hepato-Gastroenterology, 2018
A novel therapeutic vaccine for chronic hepatitis B (CHB) treatment comprising the recombinant hepatitis B surface (HBsAg) and nucleocapsid (HBcAg) antigens has been developed.
Guillermo Fernández, Ana L Sanchez, Everardo Jerez, Luis E Anillo, F. Freyre, Jorge A Aguiar, Yamila León, Z. Cinza, Pablo A Diaz, Nelvis Figueroa, V. Muzio, Gerardo G Nieto, Y. Lobaina, Arı́stides Aguilar, E. Pentón, Julio C Aguilar   +15 more
semanticscholar   +1 more source

Nanomaterial-based delivery vehicles for therapeutic cancer vaccine development

Cancer Biology and Medicine, 2021
Nanomaterial-based delivery vehicles such as lipid-based, polymer-based, inorganics-based, and bio-inspired vehicles often carry distinct and attractive advantages in the development of therapeutic cancer vaccines.
Jie Liang, Xiao Zhao
semanticscholar   +1 more source

The temporal trends and short‐ and long‐term mortality of people with acute myocardial infarction and rheumatoid arthritis: a nationwide cohort study

Arthritis Care &Research, Accepted Article.
Aims We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analysed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalised with AMI between 2005 and 2019 from the MINAP registry, linked ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A Mamas   +8 more
wiley   +1 more source

Oral Immunization with a Multivalent Epitope-Based Vaccine, Based on NAP, Urease, HSP60, and HpaA, Provides Therapeutic Effect on H. pylori Infection in Mongolian gerbils

Frontiers in Cellular and Infection Microbiology, 2017
Epitope-based vaccine is a promising strategy for therapeutic vaccination against Helicobacter pylori (H. pylori) infection. A multivalent subunit vaccine containing various antigens from H. pylori is superior to a univalent subunit vaccine.
Le Guo, Le Guo, Le Guo, Hua Yang, Feng Tang, Runting Yin, Hongpeng Liu, Xiaojuan Gong, Jun Wei, Jun Wei, Ying Zhang, Guangxian Xu, Guangxian Xu, Kunmei Liu, Kunmei Liu   +14 more
doaj   +1 more source

Immunogenicity of targeted lentivectors [PDF]

, 2014
To increase the safety and possibly efficacy of HIV-1 derived lentivectors (LVs) as an anti-cancer vaccine, we recently developed the Nanobody (Nb) display technology to target LVs to antigen presenting cells (APCs).
Adotévi, Bennett, Bevan, Bhardwaj, Bhardwaj, Bhardwaj, Blander, Bonehill, Bonehill, Breckpot, Breckpot, Breckpot, Charleston, Chuah, Collins, Collins, Collins, Collins, Cosset, Diebold, Donckier, Eggermont, Enk, Figdor, Gajewski, Garcia, Groettrup, Inaba, Kast, Lahoutte, Lévy, McCullough, Medzhitov, Melief, Mellman, Mortha, Moser, Moser, Munn, Naldini, Neyns, Noguiez-Hellin, Nussenzweig, Palena, Raes, Reis e Sousa, Reiser, Reiser, Richardson, Romani, Roncarolo, Sakuma, Schroyens, Semesyuk, Song, Storm, Thielemans, Thielemans, Thielemans, Thielemans, Torretta, Turk, Van Kooyk, Wang, Wang, Yamaguchi, Yewdell, Yu   +67 more
core   +3 more sources