Results 201 to 210 of about 3,300,951 (351)

The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy [PDF]

, 2014
Breckpot, Karine, De Smedt, Stefaan, Dewitte, Heleen, Heirman, Carlo, Lentacker, Ine, Thielemans, Kris, Van Lint, Sandra   +6 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

A hepatitis B virus-derived peptide combined with HBsAg exerts an anti-HBV effect in an HBV transgenic mouse model as a therapeutic vaccine. [PDF]

Front Immunol, 2023
Choi YM, Kim DH, Jang J, Kim BJ.
europepmc   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Circular RNA-based HPV16 therapeutic vaccine elicits potent and durable antitumor immunity. [PDF]

J Exp Clin Cancer Res
Zhou R, Li C, Xiang K, Cui L, Rong Y, Li L, Zhu M, Zeng J, Gao L.   +8 more
europepmc   +1 more source

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

Advanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta, Mette Galsgaard Malle, Emily Tsang, Marjan Omer, Mads K. Skaanning, Sarah Youssef, Jørgen Kjems, Kurt V. Gothelf   +7 more
wiley   +1 more source

Randomized field trial of a therapeutic vaccine against Trypanosoma cruzi natural infection in dogs and correlates for efficacy. [PDF]

NPJ Vaccines
Calderón-Quintal JA, Teh-Poot CF, Pech-Pisté LM, Martinez-Vega PP, Dzul-Huchim V, Torres-Acosta JF, Waleckx E, Villanueva-Lizama L, Ortega-Lopez J, Herrera C, Dumonteil E, Cruz-Chan JV.   +11 more
europepmc   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Erratum: Bio-nanoparticle based therapeutic vaccine induces immunogenic response against triple negative breast cancer. [PDF]

Am J Cancer Res
Bai X, Zhou Y, Lin Q, Huang CK, Zhang S, Carlson RI, Ghanbari H, Sun B, Wands JR, Dong X.   +9 more
europepmc   +1 more source

Investigation of the Optimal Prime Boost Spacing Regimen for a Cancer Therapeutic Vaccine Targeting Human Papillomavirus. [PDF]

Cancers (Basel), 2022
Da Silva DM, Martinez EA, Bogaert L, Kast WM.   +3 more
europepmc   +1 more source