Results 41 to 50 of about 1,969,671 (301)

Therapeutic dendritic cell vaccines engineered with antigen‐biomineralized Bi2S3 nanoparticles for personalized tumor radioimmunotherapy

Aggregate, 2022
Therapeutic vaccines, an exciting development in cancer immunotherapy, share the goal of priming of personalized antigen‐specific T‐cell response by precise antigen presentation of dendritic cells (DCs), but major obstacles include insufficient antigen ...
Huan Yu, Haoxiang Guo, He Zu, Heng Ding, Subin Lin, Yangyun Wang, Leshuai W Zhang, Yong Wang   +7 more
doaj   +1 more source

New Approaches to Dendritic Cell-Based Therapeutic Vaccines Against HIV-1 Infection

Frontiers in Immunology, 2022
Due to the success of combined antiretroviral therapy (cART) in recent years, the pathological outcome of Human Immunodeficiency Virus type 1 (HIV-1) infection has improved substantially, achieving undetectable viral loads in most cases.
Marisierra Espinar-Buitrago, Marisierra Espinar-Buitrago, Ma Angeles Muñoz-Fernández, Ma Angeles Muñoz-Fernández, Ma Angeles Muñoz-Fernández, Ma Angeles Muñoz-Fernández   +5 more
doaj   +1 more source

Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus [PDF]

, 2020
The success in preventing hepatitis B virus and human papillomavirus infections by means of vaccination paves the way for the development of other vaccines to prevent sexually transmitted infections (STIs) such as gonorrhoea, syphilis, chlamydia, herpes ...
McIntosh, Edwin David G.
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy

OncoImmunology, 2017
Purpose: Although local oncolytic viral therapy (OVT) may enhance tumor lysis, antigen release, and adaptive immune responses, systemic antitumor responses post-therapy are limited. Adoptive immunotherapy with autologous dendritic cells (DC) and cytokine-
Jun Ren, William R. Gwin, Xinna Zhou, Xiaoli Wang, Hongyan Huang, Ni Jiang, Lei Zhou, Pankaj Agarwal, Amy Hobeika, Erika Crosby, Zachary C. Hartman, Michael A. Morse, Kevin H. Eng, H. Kim Lyerly   +13 more
doaj   +1 more source

Potential Therapeutic Target and Vaccines for SARS-CoV-2

, 2023
The coronavirus has become the most interesting virus for scientists because of the recently emerging deadly SARS-CoV-2. This study aimed to understand the behavior of SARS-CoV-2 through the comparative genomic analysis with the closest one among the ...
Kholoud F. Ghazawi, Tarig A. Gamar, Mohamed A. Hussain, Ahmed Ashour, Ahmed Osman Mohamed, Aisha A. Alhaddad, Yusra Saleh Andijani, Asmaa E. Sherif, Bashir Abdrhman Bashir, Mohamed M. Hassan, Abdelaziz Elgaml, Elmuaiz Gasmalbari, Samar F. Miski, Wadah Osman, Bayan E. Ainousah, Gamal A. Mohamed, Sabrin R. M. Ibrahim   +16 more
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Cancer vaccines: Enhanced immunogenic modulation through therapeutic combinations

, 2017
Therapeutic cancer vaccines have gained significant popularity in recent years as new approaches for specific oncologic indications emerge. Three therapeutic cancer vaccines are FDA approved and one is currently approved by the EMA as monotherapy with ...
Collins, Julie M., Marijo Bilusic, Gatti-Mays, Margaret E., Julie M. Collins, Jason M. Redman, Margaret E. Gatti-Mays, Redman, Jason M., Bilusic, Marijo   +7 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery

mBio, 2017
Drug-resistant mycobacterial infections are a serious global health challenge, leading to high mortality and socioeconomic burdens in developing countries worldwide.
Dirk Bald, Cristina Villellas, Ping Lu, Anil Koul   +3 more
doaj   +1 more source