Results 61 to 70 of about 1,969,671 (301)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Therapeutic vaccines [PDF]

Human Vaccines & Immunotherapeutics, 2013
Personalized therapy is directed at obtaining maximal therapeutic effect on diseased tissue with minimal off-target side effects. Many classes of therapeutics have attempted to reach this ideal, only to fall well short. Therapeutic vaccines represent a novel class of therapies that can induce a dynamic immune response that, in theory, can continue to ...
openaire   +2 more sources

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Therapeutic HPV DNA vaccines [PDF]

Immunologic Research, 2010
It is now well established that most cervical cancers are causally associated with HPV infection. This realization has led to efforts to control HPV-associated malignancy through prevention or treatment of HPV infection. Currently, commercially available HPV vaccines are not designed to control established HPV infection and associated premalignant and ...
Ken, Lin, Elena, Roosinovich, Barbara, Ma, Chien-Fu, Hung, T-C, Wu   +4 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

High awareness, inadequate practices: a cross-sectional KAP study on Chagas disease in an endemic Venezuelan community

Tropical Medicine and Health
Background Chagas disease, caused by Trypanosoma cruzi, remains a significant public health problem in Venezuela, with evidence of re-emerging transmission and increasing concern over non-vectorial routes such as oral and congenital transmission ...
Iván A. Escalante-Pérez, Fhabián S. Carrión-Nessi, Grecia de J. Erimee-Vieira, Mariana de J. de Marchis-Vento, Óscar D. Omaña-Ávila, Mario A. Dubuc-Ponte, Daniela I. Castro-Betancourt, Vanessa C. Sande-Mujica, Juan M. Contreras-Rengifo, Rachell A. Molina-Mendoza, Alejandro M. Loreto-Rodrigues, Juan C. Gomes-González, René Haddad-Soto, Daniela L. Mendoza-Millán, Belkisyolé Alarcón de Noya, David A. Forero-Peña   +15 more
doaj   +1 more source

Protocol for identifying stressed granulocytes from septic mice

STAR Protocols
Summary: Sepsis trains stressed granulocytes to boost nonspecific response and trigger a new wave of inflammation when facing secondary infection. Here, we present a protocol for a murine model of sepsis with secondary infection.
Yu Hao, Can Zhang, Fangyuan Li, Yang Fan, Kexin Chi, Hui Zeng, Ju Zhang   +6 more
doaj   +1 more source

Management of visceral leishmaniasis with therapeutic vaccines

, 2016
Visceral leishmaniasis (VL), a phlebotomine-borne neglected tropical disease, is caused by parasites of the Leishmania donovani complex. While L.
Ratnapriya, Sneha, Sahasrabuddhe, Amogh A., Dube, Anuradha, Rawat, Keerti, Joshi, Sumit, Yadav, Narendra K.   +5 more
core   +1 more source

Development of mRNA vaccines and their prophylactic and therapeutic applications

, 2021
Nucleic acid vaccines have attracted enormous attention for resolving the limitations of conventional vaccines using live attenuated viruses. Because nucleic acid vaccines can be produced rapidly in response to the emergence of new virus strains, they ...
이혁진, 이규리, 김민정
core   +1 more source