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TB and HIV Therapeutics: Pharmacology Research Priorities [PDF]

AIDS Research and Treatment, 2012
An unprecedented number of investigational drugs are in the development pipeline for the treatment of tuberculosis. Among patients with tuberculosis, co-infection with HIV is common, and concurrent treatment of tuberculosis and HIV is now the standard ...
Kelly E. Dooley, Peter S. Kim, Sharon D. Williams, Richard Hafner   +3 more
doaj   +2 more sources

Educating Medical Students on How to Prescribe Anti-Hyperglycaemic Drugs: A Practical Guide

Diabetology, 2023
In the light of the rapidly increasing global incidence of, and therapeutic arsenal for, diabetes type 2, this brief report underscores the need for advancements in clinical pharmacology and therapeutics (CPT) education with regard to diabetes type 2. We
Erik M. Donker, Andrej Belančić, Joost D. Piët, Dinko Vitezić, Jelle Tichelaar, on behalf of the Clinical Pharmacology and Therapeutics Teach the Teacher (CP4T) Program and the Early Career Pharmacologists of the European Association for Clinical Pharmacology and Therapeutics (EACPT)   +5 more
doaj   +1 more source

Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study

Journal of Diabetes Research, 2022
Aims. This study is aimed at clarifying the relationship between visit-to-visit variability of glycated hemoglobin (HbA1c) and the risk of diabetic kidney disease (DKD) and to identifying the most useful index of visit-to-visit variability of HbA1c ...
Yunyi Yan, Nozomi Kondo, Kentaro Oniki, Hiroshi Watanabe, Tadashi Imafuku, Yuki Sakamoto, Takuro Shigaki, Akari Maruyama, Hitomi Nakazawa, Tetsuya Kaneko, Ayami Morita, Akira Yoshida, Hitoshi Maeda, Toru Maruyama, Hideaki Jinnouchi, Junji Saruwatari   +15 more
doaj   +1 more source

Phytochemical Analysis, Acute Toxicity, as well as Antihyperglycemic and Antidiabetic Activities of Corchorus olitorius L. Leaf Extracts

The Scientific World Journal, 2022
Backgroundand Aim. Diabetes mellitus is a metabolic disorder that has no known cure with continuous endeavors to find a therapy for the condition. According to some studies, traditional leafy vegetables could prevent and manage diabetes by modifying the ...
Rebecca Nakaziba, Aloysius Lubega, Jasper Ogwal-Okeng, Paul E. Alele   +3 more
doaj   +1 more source

Time to Step Up: A Call to Action For the Clinical and Quantitative Pharmacology Community to Accelerate Therapeutics for COVID‐19

Clinical and Translational Science, 2020
The global response to finding therapeutics for coronavirus disease 2019 (COVID‐19) is chaotic even if well intentioned. There is an opportunity, but more importantly, an obligation for the global clinical and quantitative pharmacology community to come ...
Dan Hartman, Steven Kern, Fran Brown, Suzanne K. Minton, Craig R. Rayner   +4 more
doaj   +1 more source

Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes

Scientific Reports, 2023
The inaccessibility of human cardiomyocytes significantly hindered years of cardiovascular research efforts. To overcome these limitations, non-human cell sources were used as proxies to study heart function and associated diseases.
Kyla Bourque, Jace Jones-Tabah, Darlaine Pétrin, Ryan D. Martin, Jason C. Tanny, Terence E. Hébert   +5 more
doaj   +1 more source

Network Pharmacology-Based Strategy for the Investigation of the Anti-Obesity Effects of an Ethanolic Extract of Zanthoxylum bungeanum Maxim

Frontiers in Pharmacology, 2020
Network pharmacology is considered as the next paradigm in drug discovery. In an era when obesity has become global epidemic, network pharmacology becomes an ideal tool to discover novel herbal-based therapeutics with effective anti-obesity effects ...
Ying Wang, Song Hong Yang, Keying Zhong, Ting Jiang, Mi Zhang, Hiu Yee Kwan, Tao Su   +6 more
doaj   +1 more source

Ethnomedicinal applications, phytochemistry, and pharmacological properties of Laggera aurita Linn (Asteraceae): A Review

Bulletin of the National Research Centre, 2022
Background The plant Laggera aurita (Asteraceae) is a commonly utilized medicinal plant growing as a weed in African countries used in the treatment of many diseases.
Sa’adatu Muhammad Julde, Safiya Bala Borodo, Abubakar Sadiq Wada, Mubarak Hussaini Ahmad, Sani Malami, Lawal Alhassan Bichi   +5 more
doaj   +1 more source

A pharmacological characterization of Cannabis sativa chemovar extracts

Journal of Cannabis Research, 2020
Background Cannabis contains Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) as the primary constituents responsible for pharmacological activity.
Alykhan Devsi, Brett Kiyota, Theophile Ouellette, Andrew P. Hegle, Ricardo E. Rivera-Acevedo, Jasper Wong, Ying Dong, Michael K. Pugsley, Timothy Fung   +8 more
doaj   +1 more source

American Society for Pharmacology and Experimental Therapeutics Division for Pharmacology Education at EB2022—Meeting report

Pharmacology Research & Perspectives, 2022
The American Society for Pharmacology and Experimental Therapeutics (ASPET) held its annual meeting at the Experimental Biology 2022 conference in Philadelphia, PA on April 2–5, 2022.
Joe B. Blumer, Marieke Kruidering, Katharina Brandl, Brooks McPhail, Mark A. Simmons   +4 more
doaj   +1 more source