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The impact of dietary factors on the function of brown and beige adipose tissues—implications on health and disease [PDF]

Frontiers in Nutrition
The development of strategies that promote the activation of adaptive thermogenesis in brown and beige adipose tissues is expected to lead to advances in the prevention and treatment of obesity, diabetes, and cardiovascular diseases.
Bruna Bombassaro, Gabriela Batitucci, Marcela Reymond Simoes, Eliana P. Araujo, Eliana P. Araujo, Licio A. Velloso, Licio A. Velloso, Licio A. Velloso   +7 more
doaj   +2 more sources

Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner [PDF]

Journal of Translational Medicine
Adaptive thermogenesis driven by brown/beige adipose tissue has gained attention as a promising strategy for combating obesity. Histone methyltransferase SET and MYND Domain Containing 3 (Smyd3) is strongly associated with metabolic and cardiovascular ...
Meiling Shu, Youzhen Ma, Dandan Zhao, Chen Meng, Lang Chen, Leihao Wang, Jing Liu, Di Yang   +7 more
doaj   +2 more sources

Huddling behavior regulate adaptive thermogenesis in Brandt’s voles (Lasiopodomys brandtii) [PDF]

Cell & Bioscience
Background Brown adipose tissue (BAT) is the main site of non-shivering thermogenesis (NST) in small mammals, playing an important role in maintaining body temperature and energy balance. Huddling is a behavioral strategy for small rodents to save energy
Min Liu, De-Sheng Zou, Xue-Ying Zhang, De-Hua Wang   +3 more
doaj   +2 more sources

Identification of key genes regulating brown adipose tissue thermogenesis in goat kids (Capra hircus) by using weighted gene co-expression network analysis [PDF]

Frontiers in Veterinary Science
Brown adipose tissue (BAT) is crucial for the maintenance of body temperature in newborn animals through non-shivering thermogenesis (NST). However, which kind key genes involved in the regulation of BAT thermogenesis and the internal regulation ...
Minhao Li, Qingjun Zhu, Haili Yang, Yunyi Hu, Le Zhao, Yongju Zhao   +5 more
doaj   +2 more sources

Emerging roles of histone deacetylases in adaptive thermogenesis

Frontiers in Endocrinology, 2023
Brown and beige adipose tissues regulate body energy expenditure through adaptive thermogenesis, which converts energy into heat by oxidative phosphorylation uncoupling.
Ruonan Zhou, Ruonan Zhou, Yue Cao, Yue Cao, Yingying Xiang, Yingying Xiang, Penghua Fang, Wenbin Shang, Wenbin Shang   +8 more
doaj   +1 more source

Heat production and volatile biosynthesis are linked via alternative respiration in Magnolia denudata during floral thermogenesis

Frontiers in Plant Science, 2022
Floral thermogenesis is coupled with odor emission in known thermogenic plants. It is widely accepted that elevation in floral temperature can help release of volatile organic compounds (VOCs).
Ruohan Wang, Ruohan Wang, Ling Chen, Ling Chen, Yaping Jia, Yaping Jia, Liya Liu, Liwei Sun, Liwei Sun, Yujun Liu, Yujun Liu, Yun Li, Yun Li   +12 more
doaj   +1 more source

Brown adipocyte and browning thermogenesis: metabolic crosstalk beyond mitochondrial limits and physiological impacts

Adipocyte, 2023
Brown adipocytes were proposed to reverse metabolic conditions such as obesity and diabetes, which make them potential for therapeutic applications.
Van Thi-Tuong Nguyen, Vuong Van Vu, Phuc Van Pham   +2 more
doaj   +1 more source

A subpopulation of Bdnf-e1–expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control

Molecular Metabolism, 2020
Objective: Brown adipose tissue (BAT)–mediated thermogenesis plays a key role in energy homeostasis and the maintenance of body temperature. Previous work suggests that brain-derived neurotrophic factor (BDNF) is involved in BAT thermogenesis, but the ...
He You, Pengcheng Chu, Wei Guo, Bai Lu
doaj   +1 more source

AMPK in the Ventromedial Nucleus of the Hypothalamus: A Key Regulator for Thermogenesis

Frontiers in Endocrinology, 2020
Obesity has become a global health issue, but effective therapies remain very limited. Adaptive thermogenesis promotes weight loss by dissipating energy in the form of heat, thereby representing a promising target to counteract obesity.
Hailan Liu, Hailan Liu, Yong Xu, Yong Xu, Fang Hu   +4 more
doaj   +1 more source

Transcriptome Profiles of the Liver in Two Cold-Exposed Sheep Breeds Revealed Different Mechanisms and Candidate Genes for Thermogenesis

Genetics Research, 2021
Cold-induced thermogenesis plays an important role in the survival of lambs exposed to low air temperatures. The liver produces and mediates heat production in mammals; however, to date, little is known about the role of liver genes in cold-induced ...
Dan Jiao, Kaixi Ji, Wenqiang Wang, Hu Liu, Jianwei Zhou, A. Allan Degen, Yunsheng Zhang, Ping Zhou, Guo Yang   +8 more
doaj   +1 more source