Results 181 to 190 of about 37,151 (264)

Six‐ and Twelve‐Month Changes in Body Composition and 24‐h Energy Expenditure After a Very Low‐Calorie Ketogenic Diet

open access: yesObesity, Volume 34, Issue 8, Page 1558-1568, August 2026.
ABSTRACT Objective This study assessed changes in body composition and 24‐h energy metabolism at 6 and 12 months after initiation of a 1‐month very low‐calorie ketogenic diet (VLCKD) in women with obesity. Methods Seventeen women with obesity who completed a 1‐month VLCKD underwent a 4‐week transition phase with carbohydrate reintroduction, followed by
Alessio Basolo   +10 more
wiley   +1 more source

TRPC6 governs brown adipose thermogenesis via a BMPR2-p38 MAPK signaling axis. [PDF]

open access: yesMol Metab
Xie D   +7 more
europepmc   +1 more source

Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity

open access: yesObesity, Volume 34, Issue 8, Page 1569-1582, August 2026.
Protein restriction, while meeting minimum requirements, induced weight loss and increased FGF21 in men with obesity under isocaloric conditions, without caloric restriction. ABSTRACT Objective Dietary protein reduction increases plasma fibroblast growth factor 21 (FGF21) and energy requirements in lean men under eucaloric conditions.
Aslak E. Lyster   +10 more
wiley   +1 more source

ASK1‐Induced FGF21 Synthesis in the Liver Prevents Obesity in Mice

open access: yesObesity, Volume 34, Issue 8, Page 1635-1646, August 2026.
ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is a stress‐induced hormone secreted by the liver. It has a beneficial role in the regulation of glucose and energy metabolism. Herein, we identify apoptosis signal regulating kinase 1 (ASK1) as an inducer of hepatic FGF21 synthesis.
Anne Goergen   +8 more
wiley   +1 more source

The GLP‐1–Mitochondria Axis in Metabolic Aging

open access: yesAging Cell, Volume 25, Issue 8, August 2026.
Glucagon‐like peptide‐1 receptor agonists engage AMPK–PGC‐1α signaling to remodel mitochondrial biogenesis, dynamics, and quality control, but downstream effects are context‐dependent and tissue‐specific rather than uniformly receptor‐proximal. Whether this proposed mitochondria‐incretin axis reflects a novel geroscience mechanism or indirect metabolic
Renin Chang   +3 more
wiley   +1 more source

Human Islet miR‐199a‐5p and miR‐214‐3p Associate With Donor Age, BMI, and Sex and Mediate Cellular Aging in Islet‐Derived Cells

open access: yesActa Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Objectives Human islets are widely researched to understand pathophysiological mechanisms leading to diabetes. Sex, age, and body mass index (BMI) are key donor traits influencing islet function, which is also regulated by an intricate network of microRNAs.
Wilson K. M. Wong   +18 more
wiley   +1 more source

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