Results 191 to 200 of about 37,151 (264)

Under Control? Mouse Models of Heat Exposure: A Systematic Review of Experimental Design and Methodology

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Mouse models are widely used to study heat‐related physiological responses as they provide insights relevant to human health. However, species differences (including nocturnal behavior) and standard housing below the thermoneutral zone (TNZ; 26°C–34°C) can confound comparisons.
Amina H. Rhaman, Leaf R. Kardol, Shane K. Maloney, Ebony Quintrell, Elizabeth Sorial, Shannon Morgan, Danielle J. Russell, Erin Kelty, Caitlin S. Wyrwoll   +8 more
wiley   +1 more source

Editorial: Targeting adipose tissue for the treatment of metabolic alterations. [PDF]

Front Pharmacol
Flori L, Ramos-Molina B, Calderone V, Martelli A.   +3 more
europepmc   +1 more source

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4953-4968, August 2026.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Myeloid GHSR Deficiency Protects Against Thermogenic Impairment in Aging Through Immune Remodeling of Brown Adipose Tissue. [PDF]

Cells
Han HW, Kim DM, Baratiboldaji R, Wang H, Liu Z, Shen Z, Jha DK, Teferra T, Septiningsih EM, Patil B, Sun Y.   +10 more
europepmc   +1 more source

Association of Physical Activity With All‐Cause and CVD Mortality Across Metabolic and Obesity Phenotypes

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7006-7017, August 2026.
ABSTRACT Aims To examine the independent and joint associations of metabolic status, obesity, and physical activity with all‐cause and cardiovascular disease (CVD) mortality across metabolic–obesity phenotypes. Materials and Methods We analysed 442 666 adults from the Korean National Health Insurance Service health screening cohort (2009–2012 ...
Yunmin Han, Younghwan Choi, Soomin Lee, Yeon Soo Kim   +3 more
wiley   +1 more source

Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms. [PDF]

Nat Commun
Wang C, He N, Wang S, Lei M, Yao J, Lin L, Ding X, Lin J, Chen Y, Long Q, Hui HX, Xie L, Chan YS, Cao N, Gu S, Hu W.   +15 more
europepmc   +1 more source

Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta‐Analyses

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6919-6926, August 2026.
ABSTRACT Aims The brain plays a critical role in controlling energy balance. Previous studies have mainly focused on dopaminergic mechanisms, whereas much less attention has been paid to serotonin during the emergence of overweight and obesity. Therefore, this study investigated the association between serotonin transporter (SERT) availability and ...
Kyoungjune Pak
wiley   +1 more source

The Physiological Significance of TRP and Piezo Channels as Physical Stimulus Sensors in Brown Adipocytes. [PDF]

Cells
Uchida K, Iwase M.
europepmc   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, Volume 293, Issue 15, Page 4489-4507, August 2026.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

C2CD5 in noradrenergic neurons regulates thermogenesis and lipid homeostasis via norepinephrine secretion. [PDF]

iScience
Gavini CK, Labouèbe G, Gorostidi F, Mansuy-Aubert V.   +3 more
europepmc   +1 more source