Results 21 to 30 of about 85,969 (275)

A PGC1α-dependent myokine that drives browning of white fat and thermogenesis

Nature, 2012
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α).
P. Boström, Jun Wu, Mark P. Jedrychowski, Anisha Korde, L. Ye, J. Lo, K. Rasbach, E. Boström, J. Choi, J. Long, S. Kajimura, M. C. Zingaretti, B. Vind, H. Tu, S. Cinti, K. Højlund, S. Gygi, B. Spiegelman   +17 more
semanticscholar   +1 more source

AMPK in the Ventromedial Nucleus of the Hypothalamus: A Key Regulator for Thermogenesis

Frontiers in Endocrinology, 2020
Obesity has become a global health issue, but effective therapies remain very limited. Adaptive thermogenesis promotes weight loss by dissipating energy in the form of heat, thereby representing a promising target to counteract obesity.
Hailan Liu, Hailan Liu, Yong Xu, Yong Xu, Fang Hu   +4 more
doaj   +1 more source

Transcriptome Profiles of the Liver in Two Cold-Exposed Sheep Breeds Revealed Different Mechanisms and Candidate Genes for Thermogenesis

Genetics Research, 2021
Cold-induced thermogenesis plays an important role in the survival of lambs exposed to low air temperatures. The liver produces and mediates heat production in mammals; however, to date, little is known about the role of liver genes in cold-induced ...
Dan Jiao, Kaixi Ji, Wenqiang Wang, Hu Liu, Jianwei Zhou, A. Allan Degen, Yunsheng Zhang, Ping Zhou, Guo Yang   +8 more
doaj   +1 more source

Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue

Nature Metabolism, 2021
Beiging of white adipose tissue (WAT) is associated with an increase of anti-inflammatory M2-like macrophages in WAT. However, mechanisms through which M2-like macrophages affect beiging are incompletely understood.
Yi-Na Wang, Yan Tang, Zhihui He, Hong Ma, Linyuan Wang, Yang Liu, Qi-qi Yang, Dongning Pan, Cuiqing Zhu, S. Qian, Q. Tang   +10 more
semanticscholar   +1 more source

UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes

Frontiers in Endocrinology, 2020
Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient ...
K. Ikeda, Tetsuya Yamada
semanticscholar   +1 more source

Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats

Scientific Reports, 2021
The role of central orexin in the sympathetic control of interscapular brown adipose tissue (iBAT) thermogenesis has been established in rodents. Stimulatory doses of caffeine activate orexin positive neurons in the lateral hypothalamus, a region of the ...
L. Van Schaik, C. Kettle, R. Green, W. Sievers, M. W. Hale, H. R. Irving, D. R. Whelan, J. A. Rathner   +7 more
doaj   +1 more source

Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway

International Journal on Biological Sciences, 2021
Pharmacological stimulation of adipose tissue remodeling and thermogenesis to increase energy expenditure is expected to be a viable therapeutic strategy for obesity.
Yingxi Xu, Tianhao Yu, Guo-Yi Ma, Li-xia Zheng, Xue Jiang, Fan Yang, Zhuo Wang, Na Li, Zheng He, Xiaoyu Song, D. Wen, J. Kong, Yang Yu, Liu Cao   +13 more
semanticscholar   +1 more source

Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation

Molecular Metabolism, 2022
Objective: Genome-wide association studies identified ORMDL3 as an obesity-related gene, and its expression was negatively correlated with body mass index.
Yu Song, Wenying Zan, Liping Qin, Shuang Han, Lili Ye, Molin Wang, Baichun Jiang, Pan Fang, Qiji Liu, Changshun Shao, Yaoqin Gong, Peishan Li   +11 more
doaj   +1 more source

Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue [PDF]

, 2007
In response to cold, norepinephrine (NE)-induced triacylglycerol hydrolysis (lipolysis) in adipocytes of brown adipose tissue (BAT) provides fatty acid substrates to mitochondria for heat generation (adaptive thermogenesis).
Bianco, Antonio C., Christoffolete, Marcelo A., D'Eon, Tara M., Greenberg, Andrew S., Imachi, Hitomi, Miyoshi, Hideaki, Obin, Martin S., Perfield, James W., II, Ribeiro, Miriam O., Rogers, Nicole H., Souza, Sandra C., Stancheva, Zlatina S., Strissel, Katherine J.   +12 more
core   +1 more source

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

Nature Communications, 2021
Obesity results from a caloric imbalance between energy intake, absorption and expenditure. In both rodents and humans, diet-induced thermogenesis contributes to energy expenditure and involves the activation of brown adipose tissue (BAT). We hypothesize
Bo Wang, E. Tsakiridis, Shuman Zhang, A. Llanos, Eric M. Desjardins, Julian M. Yabut, Alexander E Green, Emily A. Day, Brennan K Smith, J. Lally, Jianhan Wu, A. Raphenya, Krishna A Srinivasan, A. McArthur, S. Kajimura, J. S. Patel, M. Wade, K. Morrison, A. Holloway, G. Steinberg   +19 more
semanticscholar   +1 more source