Results 61 to 70 of about 61,831 (310)

A compendium and functional characterization of mammalian genes involved in adaptation to Arctic or Antarctic environments [PDF]

, 2017
Many mammals are well adapted to surviving in extremely cold environments. These species have likely accumulated genetic changes that help them efficiently cope with low temperatures.
A Babes, A Cardona, A Wells, A Zarbock, AC Bianco, AC Johnson, AE Locke, AM Hancock, AM Hancock, AM Hancock, C Brenker, CA Ottenheijm, CT Williams, DA Diesel, Denis M. Larkin, DF Rolfe, DL Ingram, E Eden, E Ramos-Sevillano, EA Tansey, EG Mourtzoukou, Elena V. Ignatieva, EV Ignatieva, EV Ignatieva, EV Ignatieva, F Li, FJ Wei, FM Petit, GG Giesbrecht, GJ Tattersall, H Kobayashi, HB Stoner, HJ Choi, HS Yim, I Turcan, IG Shabalina, J Dai, J Grosse-Onnebrink, J Simcox, J Stapley, JA McGrath, JL1 Salisbury, JM Bono, JY Park, K Hueffer, KC Wollenberg Valero, L Lin, L Pastenes, LM Boyden, LN Suri, M Bagheri Varzaneh, M Delahunty, M Fumagalli, M Ostrowski, M Sazzini, M Shiota, M Vornanen, MA Carrasco, MA Iakimenko, MA McAleer, MH Sedaghat, NA Abumrad, Nikolay S. Yudin, NT Loges, O Savolainen, P Librado, P Venditti, PF Scholander, PR1 Stabach, Q Zhao, R Corominas, RD Barrett, S Bröer, S Fan, S Hoban, S Labeit, S Liu, S Ma, SA Barnett, SA Savage, SF Bailey, SM González-Renteria, T Yoshida, V Kumar, VG Levitsky, VJ Lynch   +85 more
core   +2 more sources

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation

Molecular Metabolism, 2022
Objective: Genome-wide association studies identified ORMDL3 as an obesity-related gene, and its expression was negatively correlated with body mass index.
Yu Song, Wenying Zan, Liping Qin, Shuang Han, Lili Ye, Molin Wang, Baichun Jiang, Pan Fang, Qiji Liu, Changshun Shao, Yaoqin Gong, Peishan Li   +11 more
doaj  

THADA regulates the organismal balance between energy storage and heat production [PDF]

, 2017
Human susceptibility to obesity is mainly genetic, yet the underlying evolutionary drivers causing variation from person to person are not clear. One theory rationalizes that populations that have adapted to warmer climates have reduced their metabolic ...
Braeckman, Bart, Cakan-Akdogan, Gulcin, Frejno, Martin, Jabs, Markus, Males, Matilda, Moraru, Alexandra, Muelleder, Michael, Mueller, Sandra, Ralser, Markus, Strassburger, Katrin, Teleman, Aurelio A   +10 more
core   +2 more sources

Gluttony and thermogenesis revisited [PDF]

International Journal of Obesity, 1999
The evolutionary and biological significance of adaptive, homeostatic forms of heat production (thermogenesis) is reviewed. After summarizing the role and selective value of thermogenesis in body temperature regulation (shivering and non-shivering thermogenesis) and the febrile response to infection (fever), the review concentrates on diet-induced ...
openaire   +3 more sources

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo, Kexin Tong, Yeting Gan, Min Tang, Yuguo Niu, Kan Liu, Shihong Ni, Shangming Wu, Xiaoxue Jiang, Haizhou Jiang, Fei Xiao, Shanghai Chen, Wei Lv, Xiaoying Li, Feixiang Yuan, Feifan Guo   +15 more
wiley   +1 more source

The Raphe Pallidus and the Hypothalamic-Pituitary-Thyroid Axis Gate Seasonal Changes in Thermoregulation in the Hibernating Arctic Ground Squirrel (Urocitellus parryii)

Frontiers in Physiology, 2018
Thermoregulation is necessary to maintain energy homeostasis. The novel discovery of brown adipose tissue (BAT) in humans has increased research interests in better understanding BAT thermogenesis to restore energy balance in metabolic disorders.
Carla Frare, Carla Frare, Mackenzie E. Jenkins, Steven J. Soldin, Steven J. Soldin, Kelly L. Drew, Kelly L. Drew   +6 more
doaj   +1 more source

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

Consistency of metabolic responses and appetite sensations under postabsorptive and postprandial conditions [PDF]

, 2012
The present study aimed to investigate the reliability of metabolic and subjective appetite responses under fasted conditions and following consumption of a cereal-based breakfast. Twelve healthy, physically active males completed two postabsorption (PA)
Astbury, Atkinson, Atkinson, Bland, Blundell, Compher, Craig, De Castro, Emma J. Stevenson, Flint, Gibson, Hopkins, Isaksson, Javier T. Gonzalez, Katch, Levine, Miles, Penny L.S. Rumbold, Peracchi, Peronnet, Piers, Ping-Delfos, Raben, Rachel C. Veasey, Rosen, Segal, Stevenson, Stubbs, Stunkard, Weststrate   +29 more
core   +3 more sources

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Advanced NanoBiomed Research, EarlyView.
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska, Andre G. Skirtach, Anna M. Kaczmarek   +2 more
wiley   +1 more source