Results 71 to 80 of about 39,448 (266)

Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy

Journal of Advanced Research
Introduction: Promoting adipose thermogenesis is considered as a promising therapeutic intervention in obesity. However, endeavors to develop anti-obesity medications by targeting the canonical thermogenesis regulatory pathway, particularly β3-adrenergic
Sijia Lu, Quanxin Jiang, Peihui Zhou, Limin Yin, Ning Wang, Junting Xu, Qiqi Qian, Mijia Tao, Hanrui Yin, Liu Han, Yunqing Gu, Fei Gao, Junli Liu, Suzhen Chen   +13 more
doaj   +1 more source

Peach Kernel Oil Modulates Lipid Metabolism Disorder in ApoEa CRISPR/Cas9 Gene‐Disrupted Zebrafish

Food Frontiers, EarlyView.
In this study, we used CRISPR/Cas9 gene editing technology to establish a lipid metabolism disorder model of ApoEa mutant zebrafish. We applied peach kernel oil to this model and studied the mechanism of peach kernel oil regulating lipid disorder in combination with transcriptomics.
Lei Xia, Yuemi Mo, Yuntian Duan, Hu Liang, Yulu Li, Wanruo Wan, Minghuang Luo, Qianhua Li, Xueni Wang, Qing Chen, Zhengcai Du, Xiaotao Hou, Fan Zhang, Jiagang Deng, Erwei Hao   +14 more
wiley   +1 more source

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

Food Frontiers, EarlyView.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu, Haoyu Li, Youyou Zheng, Xiaoqian Chen, Xuzhi Wan, Pan Zhuang, Wei Jia, Jianxin Yao, Haoyin Liu, Hongbo Shi, Xunan Lin, Yu Zhang, Jingjing Jiao   +12 more
wiley   +1 more source

Gut Microbiota–Metabolism Axis Shapes the Individual Metabolic Phenotype of Different Microbiota‐Accessible Carbohydrates

Food Frontiers, EarlyView.
Specific MAC bioactivities are associated with gut biotransformation. ABSTRACT Increasing the intake of microbiota‐accessible carbohydrates (MACs) has emerged as a promising nutritional strategy for preventing metabolic diseases. However, the consistency of their beneficial effects remains unclear, hindering their optimized application.
Na‐Na Zhang, Guo‐Quan Shao, Xin‐Xin Guo, Jing‐Yi Zhang, Yang Li, Li‐Li Wang, Yue Zhang, Feng‐Zhong Wang, Li‐Tao Tong   +8 more
wiley   +1 more source

Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice [PDF]

, 2022
Andrea Benzi, Sonia Spinelli, Laura Sturla, Markus Heine, Alexander W. Fischer, Friedrich Koch‐Nolte, Hans‐Willi Mittrücker, Andreas H. Guse, Antonio De Flora, Jöerg Heeren, Santina Bruzzone   +10 more
openalex   +1 more source

Impacts of Diets and Food Plans in Health and Diseases—A Narrative Review

Food Safety and Health, EarlyView.
This review emphasizes different diet types, providing insights into their nutritional content and health effects. Vegetarian and vegan diets, ketogenic diets, Mediterranean diets, Western diets, pescatarian diets, flexitarian diets, and territorial diversified diets are discussed, highlighting their influences on health, and diseases.
Md. Mahbubar Rahman, Manisha Pandit, Bhawana Thukral, Morshed M. Khandoker   +3 more
wiley   +1 more source

Lipid‐Lowering Potential of Food Formulations Based on Culinary‐Treated Flours of Dioscorea bulbifera (Dana) in Obese and Hyperlipidemic Rats

Food Safety and Health, EarlyView.
This graphical abstract highlights the nutritional management of obesity through food formulations based on the two varieties (white and black) of Dioscorea bulbifera yams that has undergone culinary treatments (boiling and braising). The results show that white Dioscorea bulbifera showed the best properties compared to black after the culinary ...
Fossouo Towa Patrik Florent, Maffo Tazoho Ghislain, Tekou Florian Amel, Kenfack Justine Odelonne, Zokou Ronice, Dangang Bossi Donald Séverin, Womeni Hilaire Macaire   +6 more
wiley   +1 more source

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

Nature Communications, 2020
Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electron ...
Yingzhong Li, Nikola A. Ivica, Ting Dong, Dimitrios P. Papageorgiou, Yanpu He, Douglas R. Brown, Marianna Kleyman, Guangan Hu, Walter W. Chen, Lucas B. Sullivan, Amanda Del Rosario, Paula T. Hammond, Matthew G. Vander Heiden, Jianzhu Chen   +13 more
doaj   +1 more source

Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals

, 2023
Daniel P. Singh, Luke Pearce, Rocky H. Choi, Aldo Meizoso‐Huesca, Stefan G. Wette, John W. Scott, C. R. Lamboley, Robyn M. Murphy, Bradley S. Launikonis   +8 more
openalex   +2 more sources

Is thermogenesis really needed for brown adipose tissue–mediated metabolic benefit?

The Journal of Clinical Investigation, 2022
Brown adipose tissue (BAT) dissipates energy in the form of heat and functions as a metabolic sink for lipids, glucose, and branched-chain amino acids. Enhanced BAT thermogenesis is thought to tightly couple with beneficial energy metabolism. However, in
Jin-Seon Yook, Shingo Kajimura
doaj   +1 more source