Results 51 to 60 of about 26,595 (166)

A Strategy for Simultaneous Engineering of Interspecies Cross-Reactivity, Thermostability, and Expression of a Bispecific 5T4 x CD3 DART^® Molecule for Treatment of Solid Tumors

Antibodies
Background: Bispecific antibodies represent a promising class of biologics for cancer treatment. However, their dual specificity and complex structure pose challenges in the engineering process, often resulting in molecules with good functional but poor ...
Renhua R. Huang, Michael Spliedt, Tom Kaufman, Sergey Gorlatov, Bhaswati Barat, Kalpana Shah, Jeffrey Gill, Kurt Stahl, Jennifer DiChiara, Qian Wang, Jonathan C. Li, Ralph Alderson, Paul A. Moore, Jennifer G. Brown, James Tamura, Xiaoyu Zhang, Ezio Bonvini, Gundo Diedrich   +17 more
doaj   +1 more source

Rational protein design for enhancing thermal stability of industrial enzymes

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2018
Enzymes possessing many excellent properties such as high selectivity, consuming less energy, and producing less side products or waste have been widely applied as biocatalysts in pharmaceutical production and many industries such as biofuel ...
Le Quang Anh Tuan
doaj   +1 more source

A thermostable glucoamylase from a thermophilic Bacillus sp.: characterization and thermostability

Journal of Industrial Microbiology & Biotechnology, 2004
A thermostable glucoamylase (GA) showed optimum activity at 70 degrees C and pH 5.0. It was highly stable at pH 7.0. The half-life of the enzyme at pH 7.0 was 13, 8, and 3 h 40 min at 60, 65, and 70 degrees C respectively. The residual activity of the enzyme sample incubated at 5 psi (110 degrees C) for 30 min was about 32% of the control set ...
Rupinder K, Gill, Jagdeep, Kaur
openaire   +2 more sources

Isolation, Purification and In Vitro Characterization of a Newly Isolated Alkalophilic Phytase Produced by the Halophile Cobetia marina Strain 439 for Use as Animal Food Supplement

Fermentation
Economic development increases and brings about issues such as the secure supply of food in a sustainable way. Phytases are enzymes catalyzing phytate hydrolysis to release phosphorus in an inorganic form.
Ivanka Boyadzhieva, Kaloyan Berberov, Nikolina Atanasova, Nikolay Krumov, Lyudmila Kabaivanova   +4 more
doaj   +1 more source

The Structural Framework and Opening Appearance of the VP1-Pocket of Enteroviruses Correlated with Viral Thermostability

Pathogens
Enteroviruses (EVs and RVs) are prevalent worldwide and cause various diseases in humans, of which the VP1-pocket is a target of antivirals, with a lipid molecule as a pocket factor to stabilize the virion.
Xiaojing Lin, Jianhong Gan, Qiang Sun, Zi Li, Kun Qin, Yong Zhang, Yang Cao, Jianfang Zhou   +7 more
doaj   +1 more source

The unsung virtue of thermostability [PDF]

The Lancet, 2021
Capua I., Giaquinto C.
openaire   +2 more sources

Semi-Rational Engineering of Formate Dehydrogenase Reveals Loop Dynamics as a Key Determinant of Thermostability. [PDF]

Chembiochem
Boonkumkrong R, Soithongcharoen S, Mee-Udorn P, Chunthaboon P, Maenpuen S, Rungrotmongkol T, Watthaisong P, Tinikul R.   +7 more
europepmc   +1 more source

NbBayesLM: bayesian prediction of nanobody thermostability using protein language model. [PDF]

Front Bioinform
Shishir FS, Rudro R, Sarker B, Zhong C, Shomaji S.   +4 more
europepmc   +1 more source

Identification of thermostability-enhancing mutations in H9N2 avian influenza virus hemagglutinin. [PDF]

J Virol
Liu B, Yu H, Yan Z, Zou S, Guo J, Cai S, Hu Y, Yang Y, Yan Y, Liu H, Mei K, Li Z, Qin L, Li Y, Huang S, Wen F.   +15 more
europepmc   +1 more source

Keap1-Kelch-targeting protein-protein interaction inhibitors, but not reversibly-binding electrophiles, increase the thermostability of Keap1 in the cellular environment. [PDF]

RSC Chem Biol
Dayalan Naidu S, Dikovskaya D, Walker JM, Yee CLJ, Cafferkey AJ, Tatsuno M, Feng J, Moore TW, Johnson T, Honda T, Wells G, Suzuki T, Yamamoto M, Dinkova-Kostova AT.   +13 more
europepmc   +1 more source