Results 61 to 70 of about 38,411 (253)
Biology, 2021 l-asparaginase (EC 3.5.1.1) hydrolyzes l-asparagine to produce l-aspartate and ammonia and is widely found in microorganisms, plants, and some rodent sera. l-asparaginase used for industrial production should have good thermostability.
Xian Zhang +8 more
doaj +1 more source
Advanced Science, EarlyView.A bio‐inspired side‐chain branching strategy is developed to orchestrate a dual noncovalent conformational locking (NoCL) network, enabling the construction of perfectly planar NIR‐II phototheranostic aggregates. Such structural precision maximizes light‐harvesting efficiency and optimizes exciton dynamics, ensuring synchronized enhancements in NIR‐II ...
Cheng Lu +11 more
wiley +1 more source
Identification of novel neutralizing determinants for protection against HCV
Hepatology, EarlyView., 2022 Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua +12 more
wiley +1 more source
Advanced ScienceUnderstanding the mechanism underlying thermostabilization in naturally stable enzymes and enhancing the thermostability of unstable enzymes are crucial aspects in enzyme engineering.
Min Liao +9 more
doaj +1 more source
The influence of dipeptide composition on protein thermostability [PDF]
, 2004 In this work, the influence of dipeptide composition on protein thermostability was studied. After comparing the normalized dipeptide composition between mesophilic proteins and (hyper)thermophilic proteins, we concluded that when organism optimal growth
Yujie Cai +7 more
core +1 more source
Advanced Science, EarlyView.This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka +3 more
wiley +1 more source
Gas Atmosphere Formed in Casting by Full Mold Process
Archives of Metallurgy and Materials, 2014 A test mold was designed to investigate the full mold process. Pressure changes in a gap developing between the pattern made of foamed polystyrene and the raising column of liquid alloy were determined. Studies were conducted pouring molds with cast iron
Mocek J., Chojecki A.
doaj +1 more source
Aequorin mutants with increased thermostability
, 2014 Bioluminescent labels can be especially useful for in viv o and live animal studies due to the negligible bioluminescence background in cells and most animals, and the non-toxicity of bioluminescent reporter systems.
Dikici, Emre +4 more
core +1 more source
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Switching ATP‐Forming Phosphoryl‐Transfer Chemistry With a Restricted Set of Amino Acids
Angewandte Chemie, EarlyView.Constraints on amino acid composition relevant to prebiotic chemistry reshape enzyme chemistry by replacing the canonical mechanism within a conserved protein fold with a distinct ATP‐forming reaction, ADP disproportionation. Such constraints generate alternative catalytic solutions not observed in modern enzymes and point to chemically plausible early
Sota Yagi +3 more
wiley +2 more sources