Results 31 to 40 of about 60,226 (297)

Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT MRPS14 (uS14m) is a nuclear‐encoded ribosomal protein important for mitochondria‐specific translation. To date, only a single individual with a recessive MRPS14‐related disorder (also known as COXPD38) has been reported. We report an additional subject possessing novel compound heterozygous MRPS14 variants (p.Asp37Asn, p.Asn60Asp). The subject
Maria Gabriela Otero, Christina Freeman, Ruchi Shah, Renkui Bai, Hong Cui, Marian Castro, Zachary Myers, Eric Choy, Derek Chan, Molly Easter, Sophia Y. Zhao, Madeline Babros, Ruchi Garg, Matthew Deardorff, Franklin Moser, Tyler Mark Pierson   +15 more
wiley   +1 more source

The Role of Thiamine and Effects of Deficiency in Dogs and Cats

Veterinary Sciences, 2017
Recent pet food recalls for insufficient dietary thiamine have highlighted the importance of adequate thiamine intake in dogs and cats, as thiamine is an essential dietary nutrient with a critical role in energy metabolism.
Georgia Kritikos, Jacqueline M. Parr, Adronie Verbrugghe   +2 more
doaj   +1 more source

Pumpkin, Cauliflower and Broccoli as New Carriers of Thiamine Compounds for Food Fortification

Foods, 2021
The aim of the study is to explore the possibility of vegetables being used as carriers of thiamine. The influence of carrier type (thiamine hydrochloride—TCh and thiamine pyrophosphate—TP) for the thiamine stability were investigated.
Krystyna Szymandera-Buszka, Justyna Piechocka, Agata Zaremba, Monika Przeor, Anna Jędrusek-Golińska   +4 more
doaj   +1 more source

Iron‐MOFs for Biomedical Applications

Advanced Healthcare Materials, Volume 14, Issue 8, March 25, 2025.
This review introduces the unique properties of iron‐based metal–organic frameworks (Fe‐MOFs), the advances in synthesis and formulation, and their state‐of‐the‐art applications in biomedicine. It discusses the challenges in transitioning Fe‐MOFs from research to clinical use, emphasizing the need for eco‐friendly production methods, and a deeper ...
Zhihao Yu, Mathilde Lepoitevin, Christian Serre   +2 more
wiley   +1 more source

Morphometric‐Assisted Prediction of Developmental Toxicity Using Stem Cell‐Based Embryo Models in Microwells

Advanced Healthcare Materials, EarlyView.
This proof‐of‐concept study involves high‐throughput teratogenicity screening of compounds using XEn/EpiCs, a 3D stem cell‐based embryo model, within microwells. The term ‘morphotoxicity’ is introduced to complement traditional cytotoxicity assays through automated feature extraction and machine‐learning‐assisted classification of morphologies.
Vinidhra Shankar, Athanasia Zoi Pappa, Clemens van Blitterswijk, Erik Vrij, Stefan Giselbrecht   +4 more
wiley   +1 more source

Enzymatic Asymmetric Synthesis of All Stereoisomers of Aliphatic, Vicinal Diols in Conventional and Non‐Conventional Media

Advanced Synthesis &Catalysis, Volume 367, Issue 8, April 15, 2025.
Abstract Chiral, vicinal diols are of high interest for academic research and industrial applications. For synthesizing chiral diols, enzymes are important catalysts due to their high selectivity and ability to work under tolerable temperature and no pressure.
Maria Nicolas, Jan‐Dirk Küsters‐Spöring, Chiara Aufderheide, Helen Traving, Carina Ronja Kipp, Victoria S. Pfennig, Carsten Bolm, Petra Siegert, Dörte Rother   +8 more
wiley   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Quorum Sensing Coordinates Carbon and Nitrogen Metabolism to Optimize Public Goods Production in Pseudomonas fluorescens 2P24

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Pseudomonas fluorescens 2P24 utilizes a LasI/LasR‐type quorum sensing (QS) system, MupI/MupR, to regulate carbon and nitrogen metabolism for optimal production of secondary metabolites as public goods, including 2,4‐diacetylphloroglucinol, mupirocin, and siderophores.
Jie Li, Mengxue Nie, Hongguang Ma, Xuanying Tao, Yanxia Sun, Xinyue Tu, Pingping Zhang, Li‐Qun Zhang, Rong Jia, Yong‐Xing He, Nannan Zhang, Honghua Ge   +11 more
wiley   +1 more source

The Drosophila melanogaster Gut Microbiota Provisions Thiamine to Its Host

mBio, 2018
The microbiota of Drosophila melanogaster has a substantial impact on host physiology and nutrition. Some effects may involve vitamin provisioning, but the relationships between microbe-derived vitamins, diet, and host health remain to be established ...
David R. Sannino, Adam J. Dobson, Katie Edwards, Esther R. Angert, Nicolas Buchon   +4 more
doaj   +1 more source

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

Advanced Science, EarlyView.
The molecular recognition of the sugar moiety of GD3 and Gb3 (globotriaosylceramide) derivatives by Siglec‐7 has been thoroughly studied offering insights for cancer diagnostics and therapies. A combination of structural biology techniques, nuclear magnetic resonance (NMR) spectroscopy, physicochemical analysis, and in silico methods suggested that ...
Cristina Di Carluccio, Luis Padilla‐Cortés, Marta Tiemblo‐Martìn, Giulia Roxana Gheorghita, Rosario Oliva, Linda Cerofolini, Alessandro Antonio Masi, Celeste Abreu, Hsin‐Kai Tseng, Antonio Molinaro, Pompea Del Vecchio, Ondřej Vaněk, Chun‐Cheng Lin, Roberta Marchetti, Marco Fragai, Alba Silipo   +15 more
wiley   +1 more source