Results 41 to 50 of about 70,377 (295)
Angewandte Chemie, EarlyView.The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang +6 more
wiley +2 more sources
The role of thiamine as a resuscitator in patients with nonalcoholic medical and CNS disorders
Southwest Respiratory and Critical Care Chronicles, 2017 Thiamine (vitamin B1), a water-soluble vitamin, is an essential factor in cellular metabolism and fundamental cofactor in important biochemical cycles.
Mohamed Shehab-Eldin
doaj +1 more source
Journal of Intensive Care, 2022 Highlights Thiamine, co-supplementation of thiamine and vitamin C and co-administration of hydrocortisone, vitamin C and thiamine (HVT) had no significant effect on free days of ventilation and ICU length of stay.
Nafiseh Shokri-mashhadi +4 more
doaj +1 more source
An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation
Angewandte Chemie, EarlyView.YcaO‐catalyzed thioamidation of the ribosomal subunit protein uL16 is widespread in Pseudomonadota bacteria. We identify the iron–sulfur cluster cysteine desulfurase IscS as the sulfur donor via an IscS persulfide and observe direct IscS–uL16 interactions.
Yanqing Xue +2 more
wiley +2 more sources
THIAMINE DEFICIENCY AND ITS MANAGEMENT IN CRITICAL STATES
Вестник анестезиологии и реаниматологии, 2018 The level of thiamine in critically ill patients can be low due to the loss of fluid, nutrition disorders and increased metabolism. The deficiency of thiamine is associated with reduction of respiratory metabolism, increase in lactate level and ...
V. V. Lomivorotov +4 more
doaj +1 more source
Thiamine biosynthesis gene expression analysis in Elaeis guineensis during interactions with Hendersonia toruloidea [PDF]
, 2017 Thiamine plays an indispensable role as a cofactor in many metabolic reactions in all living organisms. The active form, thiamine pyrophosphate (TPP) functions as a cofactor in important metabolic reactions including glycolysis, pentose phosphate pathway
Yusof, Zetty Norhana Balia +2 more
core +1 more source
Biochemistry of thiamine and thiamine phosphate compounds
, 2021 peer reviewedThiamine (vitamin B1) is an essential molecule for all living organisms. It is the precursor for several phosphorylated derivatives, the most important being the coenzyme thiamine diphosphate (ThDP).
Lucien Bettendorff +3 more
core +1 more source
Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. [PDF]
PLoS ONE, 2012 Thiamine (Vitamin B1) is an essential vitamin that must be obtained from the diet for proper neurological function. At higher doses, thiamine and benfotiamine (S-benzoylthiamine O-monophosphate, BT)-a phosphorylated derivative of thiamine-have ...
Julie K Hurt +6 more
doaj +1 more source
Heliyon, 2019 Background: Benfotiamine (BFT) is a synthetic thiamine precursor with high bioavailability. It is efficient in treating complications of type 2 diabetes and has beneficial effects in mouse models of neurodegenerative diseases.
Margaux Sambon +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou +6 more
wiley +1 more source