Results 61 to 70 of about 65,595 (300)

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Physiological Mechanisms and Life History Trade‐Offs in Salmonids Shape In‐Tissue Correlations of an Essential Micronutrient

Ecology and Evolution
The lack of a fitness‐based theory of micronutrient allocation to specific tissues hinders understanding of the ultimate causes of mass juvenile mortality due to thiamine (vitamin B1) deficiency, which is an emerging threat to marine and coastal ...
Maciej Jan Ejsmond, Vittoria Todisco, Marc M. Hauber, Kjetil Hindar, Samuel Hylander   +4 more
doaj   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

Chronic Diseases and Translational Medicine, EarlyView.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian, Dan Nie, Qianyi Gao, Xingbo Mo, Huan Zhang   +4 more
wiley   +1 more source

Usefulness of central venous saturation as a predictor of thiamine deficiency in critically ill patients: a case report

Journal of Intensive Care, 2017
Background Central venous oxygen saturation (ScvO2) reflects the balance of oxygen delivery and consumption. Low ScvO2 indicates the presence of inadequate oxygen delivery, while high ScvO2 indicates reduced oxygen consumption and is sometimes associated
Genri Numata, Satoshi Kodera, Hiroyuki Kiriyama, Atsuko Nakayama, Eisuke Amiya, Arihiro Kiyosue, Masaru Hatano, Eiki Takimoto, Masafumi Watanabe, Issei Komuro   +9 more
doaj   +1 more source

Associations Between Microbial Depletion and Autonomic Dysregulation in Binge‐Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The interplay between the gut microbiome and autonomic nervous system remains unexplored in binge‐eating disorder (BED). We aimed to explore specific microbial alterations in BED and examine their potential association with cardiac vagal tone as a distinct bio‐behavioral phenotype.
Shuang Liang, Esben Strodl, Leanne Barron, Matthew Bambling, Luis Vitetta   +4 more
wiley   +1 more source

The Drosophila melanogaster Gut Microbiota Provisions Thiamine to Its Host

mBio, 2018
The microbiota of Drosophila melanogaster has a substantial impact on host physiology and nutrition. Some effects may involve vitamin provisioning, but the relationships between microbe-derived vitamins, diet, and host health remain to be established ...
David R. Sannino, Adam J. Dobson, Katie Edwards, Esther R. Angert, Nicolas Buchon   +4 more
doaj   +1 more source

Thiamine-Starved Lactococcus lactis for Producing Food-Grade Pyruvate

Lactococcus lactis is a safe lactic acid bacterium widely used in dairy fermentations. Normally, its main fermentation product is lactic acid; however, L. lactis can be persuaded into producing other compounds, e.g., through genetic engineering. Here, we
Christian Solem (538116), Shuangqing Zhao (17998379)   +1 more
core   +1 more source

Thiamine and thiamine monophosphate (TMP) in breast-milk by quartiles of whole blood thiamine diphosphate (TDP).

, 2013
Thiamine and thiamine monophosphate (TMP) in breast-milk by quartiles of whole blood thiamine diphosphate (TDP).
Hans Konrad Biesalski (317336), Sue Jean Lee (317335), François Henry Nosten (317338), Verena Ilona Carrara (17223), Wolfgang Stuetz (317333), Rose McGready (17231)   +5 more
core   +1 more source

Strategies on Designing Thiamine Analogues for Inhibition of Thiamine Diphosphate (ThDP)-dependent Enzymes: Systematic Investigation through Scaffold Switching and C2-Functionalisation

, 2023
Thiamine diphosphate (ThDP), the bioactive form of vitamin B1, is an essential coenzyme needed for processes of cellular metabolism in all organisms.
Emma S. , Rudge, Alex, Turner, Finian James, Leeper, Rimsha, Irfan, Terence C. S., Ho, Rawia A. A. , Hamid, Amjid , Iqbal, Anna K. H. , Hirsch, Alex H. Y., Chan   +8 more
core   +1 more source

Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease. [PDF]

PLoS ONE, 2017
BACKGROUNDThiamine metabolites and activities of thiamine-dependent enzymes are impaired in Alzheimer's disease (AD).OBJECTIVETo clarify the mechanism for the reduction of thiamine diphosphate (TDP), an active form of thiamine and critical coenzyme of ...
Xiaoli Pan, Shaoming Sang, Guoqiang Fei, Lirong Jin, Huimin Liu, Zhiliang Wang, Hui Wang, Chunjiu Zhong   +7 more
doaj   +1 more source