Results 31 to 40 of about 65,595 (300)

Illumina Sequencing Approach to Characterize Thiamine Metabolism Related Bacteria and the Impacts of Thiamine Supplementation on Ruminal Microbiota in Dairy Cows Fed High-Grain Diets

Frontiers in Microbiology, 2017
The requirements of thiamine in adult ruminants are mainly met by ruminal bacterial synthesis, and thiamine deficiencies will occur when dairy cows overfed with high grain diet.
Xiaohua Pan, Xiaohua Pan, Xiaohua Pan, Fuguang Xue, Xuemei Nan, Zhiwen Tang, Kun Wang, Yves Beckers, Linshu Jiang, Benhai Xiong   +9 more
doaj   +1 more source

The role of thiamine as a resuscitator in patients with nonalcoholic medical and CNS disorders

Southwest Respiratory and Critical Care Chronicles, 2017
Thiamine (vitamin B1), a water-soluble vitamin, is an essential factor in cellular metabolism and fundamental cofactor in important biochemical cycles.
Mohamed Shehab-Eldin
doaj   +1 more source

Action of the Thiamine Antagonist Bacimethrin on Thiamine Biosynthesis [PDF]

Journal of Bacteriology, 2000
ABSTRACT Bacimethrin is an analog of the 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) moiety of thiamine and inhibits the growth of Salmonella enterica serovar Typhimurium on a defined medium. Two classes of mutants that had increased bacimethrin resistance were isolated and characterized.
J L, Zilles, L R, Croal, D M, Downs
openaire   +2 more sources

Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. [PDF]

PLoS ONE, 2012
Thiamine (Vitamin B1) is an essential vitamin that must be obtained from the diet for proper neurological function. At higher doses, thiamine and benfotiamine (S-benzoylthiamine O-monophosphate, BT)-a phosphorylated derivative of thiamine-have ...
Julie K Hurt, Jennifer L Coleman, Brendan J Fitzpatrick, Bonnie Taylor-Blake, Arlene S Bridges, Pirkko Vihko, Mark J Zylka   +6 more
doaj   +1 more source

THIAMINE DEFICIENCY AND ITS MANAGEMENT IN CRITICAL STATES

Вестник анестезиологии и реаниматологии, 2018
The level of thiamine in critically ill patients can be low due to the loss of fluid, nutrition disorders and increased metabolism. The deficiency of thiamine is associated with reduction of respiratory metabolism, increase in lactate level and ...
V. V. Lomivorotov, M. N. Deryagin, M. N. Abubakirov, E. V. Fominskiy, V. A. Nepomnyaschikh   +4 more
doaj   +1 more source

Thiamine-induced endocytosis of Thi7 appears to require TORC1 and Sit4 but is not inhibited by Npr1.

, 2019
(A) Localization of Thi7-GFP in WT, sit4Δ, and npr1Δ strains complemented with the pFL36-HIS3-LYS2 or pFL36-HIS3-MET15 plasmid grown in thiamine-free medium containing proline (10 mM) as the sole nitrogen source (“Pro–Thiamine”) or on ammonium-(38 mM ...
Pierre Morsomme (37850), Jennifer Villers (7553525), Ruddy Wattiez (113228), Sylvain Nootens (6259208), Jérôme Savocco (7553516), Mathilde Bausart (7553522), Xiaoqian Chen (4172719), Martine Prévost (193977), Wilhelmine Afokpa (7553519), Henri-François Renard (7553528)   +9 more
core   +1 more source

Thiamine and benfotiamine protect neuroblastoma cells against paraquat and β-amyloid toxicity by a coenzyme-independent mechanism

Heliyon, 2019
Background: Benfotiamine (BFT) is a synthetic thiamine precursor with high bioavailability. It is efficient in treating complications of type 2 diabetes and has beneficial effects in mouse models of neurodegenerative diseases.
Margaux Sambon, Aurore Napp, Alice Demelenne, Julie Vignisse, Pierre Wins, Marianne Fillet, Lucien Bettendorff   +6 more
doaj   +1 more source

A novel PET tracer 18F-deoxy-thiamine: synthesis, metabolic kinetics, and evaluation on cerebral thiamine metabolism status

EJNMMI Research, 2020
Background Some neuropsychological diseases are associated with abnormal thiamine metabolism, including Korsakoff–Wernicke syndrome and Alzheimer’s disease.
Changpeng Wang, Siwei Zhang, Yuefei Zou, Hongzhao Ma, Donglang Jiang, Lei Sheng, Shaoming Sang, Lirong Jin, Yihui Guan, Yuan Gui, Zhihong Xu, Chunjiu Zhong   +11 more
doaj   +1 more source

Exploring the bioavailability and bioactivity of thiamine versus allithiamine: studies in Drosophila melanogaster and mice

Frontiers in Nutrition
ObjectiveThiamine (vitamin B1) is an essential micronutrient involved in carbohydrate metabolism and mitochondrial function. Allithiamine, a lipid-soluble thiamine derivative, has been proposed to exhibit thiamine bioactivity.MethodsHere, we conducted ...
Sandra Nevermann, Hannah Weiß, Alexandra Fischer, Kai Lüersen, Keita Chikamoto, Daisuke Nakata, Yoshiyuki Ishida, Takahiro Furune, Keiji Terao, Gerald Rimbach   +9 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source