Results 41 to 50 of about 60,963 (256)

Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease. [PDF]

PLoS ONE, 2017
BACKGROUNDThiamine metabolites and activities of thiamine-dependent enzymes are impaired in Alzheimer's disease (AD).OBJECTIVETo clarify the mechanism for the reduction of thiamine diphosphate (TDP), an active form of thiamine and critical coenzyme of ...
Xiaoli Pan, Shaoming Sang, Guoqiang Fei, Lirong Jin, Huimin Liu, Zhiliang Wang, Hui Wang, Chunjiu Zhong   +7 more
doaj   +1 more source

A novel multiparameter sensor for shake flask cultivations: Online biomass, dissolved oxygen, and fluorescence monitoring for comprehensive bioprocess characterization

Biotechnology Progress, EarlyView.
Abstract Shake flasks are one of the most widely used cultivation vessels in biotechnological process development. To improve the process understanding, new technologies have been reported for online monitoring of different parameters like oxygen, pH, or biomass in the last couple of years.
Lara Strehl, Anna‐Lena Kuhn, Kyra Hoffmann, Marcel Mann, Jørgen Barsett Magnus   +4 more
wiley   +1 more source

Scientific Opinion on the safety and efficacy of vitamin B1 (thiamine mononitrate) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG

EFSA Journal, 2011
Thiamine mononitrate administered via feed or water for drinking is safe for the target animals having a wide margin of safety. The use of thiamine mononitrate as an additive in animal nutrition is safe for consumers. Since no data on inhalation toxicity
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols

ChemBioChem, EarlyView.
Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen, Lucrezia Lanza, Francesco Presini, Pier Paolo Giovannini, Michael Müller   +4 more
wiley   +1 more source

Thiamine administration may increase survival benefit in critically ill patients with myocardial infarction

Frontiers in Nutrition, 2023
BackgroundMyocardial infarction (MI) is a common cardiovascular disease (CVD) in critically ill patients, leading to 17% mortality in the intensive care unit (ICU) setting. Patients with CVD frequently suffer from thiamine insufficiency, thereby thiamine
Suru Yue, Suru Yue, Jia Wang, Jia Wang, Yumei Zhao, Yumei Zhao, Enlin Ye, Dongdong Niu, Jiasheng Huang, Xiaolin Li, Yiling Hu, Xuefei Hou, Xuefei Hou, Jiayuan Wu, Jiayuan Wu   +14 more
doaj   +1 more source

Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis

Plant Molecular Biology, 2007
Thiamin pyrophosphate (TPP) is an essential enzyme cofactor required for the viability of all organisms. Whether derived from exogenous sources or through de novo synthesis, thiamin must be pyrophosphorylated for cofactor activation. The enzyme thiamin pyrophosphokinase (TPK) catalyzes the conversion of free thiamin to TPP in plants and other ...
Ajjawi, Imad, Rodriguez-Milla, Miguel Angel, Cushman, John, Shintani, David K   +3 more
openaire   +5 more sources

Biosynthesis of Ephedrine Initiated by Pyridoxal Phosphate‐Dependent Formation of Cathinone

ChemBioChem, EarlyView.
An alternative pathway to ephedra alkaloids via (S)–cathinone is investigated in plants. This pathway circumvents the formation of 1‐phenylpropane‐1,2‐dione as an intermediate, which has been part of the predominantly postulated biosynthetic pathway for the last decades. This alternative pathway involves an enzymatic pyridoxal phosphate (PLP)‐dependent
Karina Witte, Anne Behrens, Hannes M. Schwelm, Volker Auwärter, Michael Müller   +4 more
wiley   +1 more source

Perovskite Quantum Dots: Fabrication, Degradation, and Enhanced Performance Across Solar Cells, Optoelectronics, and Quantum Technologies

Carbon Energy, EarlyView.
Metal halide perovskite quantum dots (PQDs) have been extensively explored due to their unique optical/optoelectronic properties such as tunable wavelength, narrow emission, and high photoluminescence quantum efficiency. This critical review article is an overview of the fabrication methods, degradation mechanisms of PQDs and explores strategies for ...
Sikandar Aftab, Zeeshan Ali, M. Imtiaz Hussain, Mohammed A. Assiri, Najaf Rubab, Faruk Ozel, Erdi Akman   +6 more
wiley   +1 more source

Beriberi (thiamine deficiency) and high infant mortality in northern Laos.

PLoS Neglected Tropical Diseases, 2015
BackgroundInfantile beriberi (thiamine deficiency) occurs mainly in infants breastfed by mothers with inadequate intake of thiamine, typically among vulnerable populations.
Hubert Barennes, Khouanheuan Sengkhamyong, Jean Pascal René, Maniphet Phimmasane   +3 more
doaj   +1 more source

Two Key Ferredoxins for Nitrogen Fixation Have Different Specificities and Biophysical Properties

Chemistry – A European Journal, EarlyView.
Two ferredoxins, FdC and FdN, are collectively essential for the process of nitrogen fixation by the iron nitrogenase in R. capsulatus. We explore the biophysical factors, through spectroscopic and structural characterizations, which determine ferredoxin functionality and pathway specificity. The structure of FdC (PDB: 9I2A) and model of FdN (AF‐D5ARY6)
Holly Addison, Pascal Pfister, Ana Lago‐Maciel, Tobias J. Erb, Antonio J. Pierik, Johannes G. Rebelein   +5 more
wiley   +1 more source