Results 41 to 50 of about 60,226 (297)

Usefulness of central venous saturation as a predictor of thiamine deficiency in critically ill patients: a case report

Journal of Intensive Care, 2017
Background Central venous oxygen saturation (ScvO2) reflects the balance of oxygen delivery and consumption. Low ScvO2 indicates the presence of inadequate oxygen delivery, while high ScvO2 indicates reduced oxygen consumption and is sometimes associated
Genri Numata, Satoshi Kodera, Hiroyuki Kiriyama, Atsuko Nakayama, Eisuke Amiya, Arihiro Kiyosue, Masaru Hatano, Eiki Takimoto, Masafumi Watanabe, Issei Komuro   +9 more
doaj   +1 more source

Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease. [PDF]

PLoS ONE, 2017
BACKGROUNDThiamine metabolites and activities of thiamine-dependent enzymes are impaired in Alzheimer's disease (AD).OBJECTIVETo clarify the mechanism for the reduction of thiamine diphosphate (TDP), an active form of thiamine and critical coenzyme of ...
Xiaoli Pan, Shaoming Sang, Guoqiang Fei, Lirong Jin, Huimin Liu, Zhiliang Wang, Hui Wang, Chunjiu Zhong   +7 more
doaj   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Development and Breeding of Herbicide‐Resistant Sorghum for Effective Cereal‐Legume Intercropping

Advanced Science, EarlyView.
This study identified two SbALS mutations (A93T and S624N) conferring robust herbicide resistance in sorghum, facilitating efficient weed control. Structural analysis revealed that imazamox resistance is mediated by disrupted herbicide binding. Furthermore, 126 imazamox resistant soybean varieties are screened for sorghum‐soybean intercropping ...
Sanyuan Tang, Jiayang Shi, Xuefeng Li, Mingliang Yang, Chao Li, Dan Zhang, Sen Yang, Cuo Mei, Zuyong Luo, Li Zhang, Wanke Zhang, Chunrui Zhang, Chenbo Zhu, Xiaowei Ma, Ran Xia, Yuhang Chen, Jinsong Zhang, Qingshan Chen, Shouyi Chen, Qi Xie, Feifei Yu   +20 more
wiley   +1 more source

Scientific Opinion on the safety and efficacy of vitamin B1 (thiamine mononitrate) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG

EFSA Journal, 2011
Thiamine mononitrate administered via feed or water for drinking is safe for the target animals having a wide margin of safety. The use of thiamine mononitrate as an additive in animal nutrition is safe for consumers. Since no data on inhalation toxicity
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis

Plant Molecular Biology, 2007
Thiamin pyrophosphate (TPP) is an essential enzyme cofactor required for the viability of all organisms. Whether derived from exogenous sources or through de novo synthesis, thiamin must be pyrophosphorylated for cofactor activation. The enzyme thiamin pyrophosphokinase (TPK) catalyzes the conversion of free thiamin to TPP in plants and other ...
Ajjawi, Imad, Rodriguez-Milla, Miguel Angel, Cushman, John, Shintani, David K   +3 more
openaire   +5 more sources

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, Volume 100, Issue S4, Page 30-50, June 2025.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel, Julie McLaughlin, Marta Frigeni   +2 more
wiley   +1 more source

Beriberi (thiamine deficiency) and high infant mortality in northern Laos.

PLoS Neglected Tropical Diseases, 2015
BackgroundInfantile beriberi (thiamine deficiency) occurs mainly in infants breastfed by mothers with inadequate intake of thiamine, typically among vulnerable populations.
Hubert Barennes, Khouanheuan Sengkhamyong, Jean Pascal René, Maniphet Phimmasane   +3 more
doaj   +1 more source

Cooperative Photometallobiocatalysis: Nonheme Fe‐Enzyme‐Catalyzed Enantioconvergent RadicalDecarboxylative Azidation, Thiocyanation and Isocyanation of Redox‐Active Esters

Angewandte Chemie International Edition, Accepted Article.
Cooperative catalysis with an enzyme and a smallmolecule photocatalyst has very recently emerged as a potentially general activation mode to advance novel biocatalytic reactions with synthetic utility. Herein, we report cooperative photobiocatalysis involving an engineered nonheme Fe enzyme and a tailored photoredox catalyst as a unifying strategy for ...
Yang Yang, Liu-Peng Zhao, Ken Lin, Pei-Pei Xie, Huichong Liu, Hengye Xiang, Xin Liu, Yunlong Zhao, Peng Liu   +8 more
wiley   +1 more source