Results 51 to 60 of about 60,226 (297)

Characterization of the pattern of development of key compounds contributing to aroma quality of chicken meat and their metabolic markers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Eight major aroma‐contributing compounds (nonanal, octanal, dimethyl tetrasulfide, hexanal, 1‐octen‐3‐ol, (E)‐2‐nonenal, heptanal, and (E,E)‐2,4‐decadienal) were identified by electronic nose and GC‐O‐MS analysis, and their content increased with age.
Yanke Wang, Xiaojing Liu, Yongli Wang, Zhengxiao He, Guiping Zhao, Jie Wen, Huanxian Cui   +6 more
wiley   +1 more source

Investigation of a broad‐spectrum micronutrient formulation as a possible precipitant of pharmacokinetic micronutrient–drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Aims Daily broad‐spectrum micronutrients are being used by the general public and formulations are receiving research interest in mental health settings. Despite concerns about combining medicines and broad‐spectrum micronutrients in mental health care, there have not been any formal evaluations of potential interactions.
Bess M. Kew, Matthew P. Doogue, Richard McNeill, Mei Zhang, Julia J. Rucklidge, Christopher M. Frampton, Roger T. Mulder, Ben Beaglehole   +7 more
wiley   +1 more source

Sigma Factors as Potential Targets to Enhance Recombinant Protein Expression

Biotechnology and Bioengineering, Volume 122, Issue 6, Page 1598-1607, June 2025.
ABSTRACT The transcriptional factors control the expression of many genes and represent an important layer of complexity in cell factories. However, the effect of individual sigma factor deletions from a biomanufacturing perspective has not been addressed. In this contribution, growth, green fluorescence protein (GFP) expression, and oxygen consumption
Laura Pohlen, Emily García, Luz María Martínez, Noemí Flores, Jochen Büchs, Guillermo Gosset, Alvaro R. Lara   +6 more
wiley   +1 more source

High‐sensitivity real‐time monitoring of pH and respiration activity unveils metabolic dynamics in shake flask cultures

Biotechnology Progress, Volume 41, Issue 2, March/April 2025.
Abstract Erlenmeyer shake flasks are widely used during the first steps of bioprocess development. Despite their broad application in academia and industry, shake flasks usually lack standardized and user‐friendly online monitoring techniques. In this work, the pH and Respiratory Activity MOnitoring System (pH‐RAMOS) for the non‐invasive online ...
Burak Sarikaya, Karsten Günster, Luca Antonia Grebe, Eva Forsten, Katharina Hürter, Jochen Büchs, Jørgen Magnus   +6 more
wiley   +1 more source

Thiamine Metabolites and Dementia? [PDF]

EBioMedicine, 2016
The determinants of amyloid deposition in the brain, increased intracerebral phosphorylated tau, hippocampal atrophy, and loss of synapses in areas of brain (the pathogenic determinants of most dementia) remain undetermined except for Mendelian genetic disorders and higher risk of both amyloid deposition and dementia among individuals who carry the ...
openaire   +4 more sources

Online monitored characterization of Phocaeicola vulgatus for organic acid production using anaerobic microtiter plate cultivations

Biotechnology Progress, Volume 41, Issue 2, March/April 2025.
Abstract Phocaeicola vulgatus (formerly Bacteroides vulgatus), an anaerobic gut bacterium, produces several organic acids. Research on P. vulgatus is still in its infancy. However, a detailed understanding of P. vulgatus growth and metabolism is essential for its assessment as an organic acid producer.
Laura Keitel, Benjamin Schick, Gino Pohen, Stanislav Yordanov, Jochen Büchs   +4 more
wiley   +1 more source

A novel multiparameter sensor for shake flask cultivations: Online biomass, dissolved oxygen, and fluorescence monitoring for comprehensive bioprocess characterization

Biotechnology Progress, EarlyView.
Abstract Shake flasks are one of the most widely used cultivation vessels in biotechnological process development. To improve the process understanding, new technologies have been reported for online monitoring of different parameters like oxygen, pH, or biomass in the last couple of years.
Lara Strehl, Anna‐Lena Kuhn, Kyra Hoffmann, Marcel Mann, Jørgen Barsett Magnus   +4 more
wiley   +1 more source

Thiamine and benfotiamine protect neuroblastoma cells against paraquat and β-amyloid toxicity by a coenzyme-independent mechanism

Heliyon, 2019
Background: Benfotiamine (BFT) is a synthetic thiamine precursor with high bioavailability. It is efficient in treating complications of type 2 diabetes and has beneficial effects in mouse models of neurodegenerative diseases.
Margaux Sambon, Aurore Napp, Alice Demelenne, Julie Vignisse, Pierre Wins, Marianne Fillet, Lucien Bettendorff   +6 more
doaj  

Pre-analytical challenges from adsorptive losses associated with thiamine analysis

Scientific Reports
Thiamine (vitamin B1) is an essential vitamin serving in its diphosphate form as a cofactor for enzymes in the citric acid cycle and pentose-phosphate pathways.
Katie A. Edwards, Eileen A. Randall, Patricia C. Wolfe, Clifford E. Kraft, Esther R. Angert   +4 more
doaj   +1 more source

The Structural Permissiveness of Triosephosphate Isomerase (TpiA) of Escherichia coli

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
The enzyme triosephosphate isomerase has a typical (βα)8‐barrel superfold with eight βα units, linked together by loops which wrap around to form a cylinder of parallel β‐strands (β‐barrel) surrounded by a layer of parallel α‐helices. Such loops L1–L3 are candidates for insertion of extra amino acids, but genetic analyses shown in this work reveals ...
Belén Calles, Borja Pitarch, Víctor de Lorenzo   +2 more
wiley   +1 more source