Results 51 to 60 of about 34,352 (291)

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Shoshin Beriberi Induced by Long-Term Administration of Diuretics: A Case Report

Case Reports in Cardiology, 2014
Previous studies have suggested that diuretic therapy for heart failure may lead to thiamine deficiency due to the increased urinary thiamine excretion.
Naoki Misumida, Hisashi Umeda, Mitsunori Iwase   +2 more
doaj   +1 more source

Development and Breeding of Herbicide‐Resistant Sorghum for Effective Cereal‐Legume Intercropping

Advanced Science, EarlyView.
This study identified two SbALS mutations (A93T and S624N) conferring robust herbicide resistance in sorghum, facilitating efficient weed control. Structural analysis revealed that imazamox resistance is mediated by disrupted herbicide binding. Furthermore, 126 imazamox resistant soybean varieties are screened for sorghum‐soybean intercropping ...
Sanyuan Tang, Jiayang Shi, Xuefeng Li, Mingliang Yang, Chao Li, Dan Zhang, Sen Yang, Cuo Mei, Zuyong Luo, Li Zhang, Wanke Zhang, Chunrui Zhang, Chenbo Zhu, Xiaowei Ma, Ran Xia, Yuhang Chen, Jinsong Zhang, Qingshan Chen, Shouyi Chen, Qi Xie, Feifei Yu   +20 more
wiley   +1 more source

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel, Julie McLaughlin, Marta Frigeni   +2 more
wiley   +1 more source

A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern [PDF]

Open Veterinary Journal, 2017
Thiamine is a water-soluble vitamin, which participates in several vital metabolic pathways involved in energy metabolism and neurotransmitter synthesis of mammals.
Floriana Gernone, Mario Ricciardi
doaj   +1 more source

Thiamine deficiency : A case presentation and literature review [PDF]

, 2014
This case examines the complicated hospital course of a patient ultimately diagnosed with thiamine deficiency. The presentation, diagnostic work up, and treatment of a 53-year-old male with a history of schizoaffective disorder, pituitary adenoma status ...
Easter, Alyssa, Katta, Natraj
core  

Balancing Doses of EL222 and Light Improves Optogenetic Induction of Protein Production in Komagataella phaffii

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Komagataella phaffii, also known as Pichia pastoris, is a powerful host for recombinant protein production, in part due to its exceptionally strong and tightly controlled PAOX1 promoter. Most K. phaffii bioprocesses for recombinant protein production rely on PAOX1 to achieve dynamic control in two‐phase processes.
Shannon M. Hoffman, Sebastián Espinel‐Ríos, Sarah K. Kwartler, Makoto A. Lalwani, José L. Avalos   +4 more
wiley   +1 more source

Reduced brain mammillary body volumes and memory deficits in adolescents who have undergone the Fontan procedure. [PDF]

, 2020
BackgroundAdolescents with single ventricle heart disease (SVHD) who have undergone the Fontan procedure show cognitive/memory deficits. Mammillary bodies are key brain sites that regulate memory; however, their integrity in SVHD is unclear. We evaluated
Cabrera-Mino, Cristina, Halnon, Nancy J, Kumar, Rajesh, Lewis, Alan B, Moye, Stefanie, Pike, Nancy A, Roy, Bhaswati, Singh, Sadhana, Woo, Mary A   +8 more
core  

Enterohemorrhagic Escherichia coli infection inhibits colonic thiamin pyrophosphate uptake via transcriptional mechanism. [PDF]

, 2019
Colonocytes possess a specific carrier-mediated uptake process for the microbiota-generated thiamin (vitamin B1) pyrophosphate (TPP) that involves the TPP transporter (TPPT; product of the SLC44A4 gene).
Anandam, Kasin Yadunandam, Sabui, Subrata, Said, Hamid M, Subramanian, Sreya, Thompson, Morgan M   +4 more
core   +1 more source

Perovskite Quantum Dots: Fabrication, Degradation, and Enhanced Performance Across Solar Cells, Optoelectronics, and Quantum Technologies

Carbon Energy, EarlyView.
Metal halide perovskite quantum dots (PQDs) have been extensively explored due to their unique optical/optoelectronic properties such as tunable wavelength, narrow emission, and high photoluminescence quantum efficiency. This critical review article is an overview of the fabrication methods, degradation mechanisms of PQDs and explores strategies for ...
Sikandar Aftab, Zeeshan Ali, M. Imtiaz Hussain, Mohammed A. Assiri, Najaf Rubab, Faruk Ozel, Erdi Akman   +6 more
wiley   +1 more source