Results 41 to 50 of about 15,087 (252)

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. [PDF]

, 2018
A constellation of metabolic disorders, including obesity, dysregulated lipids, and elevations in blood glucose levels, has been associated with cardiovascular disease and diabetes. Analysis of data from recently published genome-wide association studies
Abad, Janna, Calvert, Meredith E, Chen, Eugene C, Chen, Ligong, Chien, Huan-Chieh, Giacomini, Kathleen M, King, Sarah, Krauss, Ronald M, Liang, Xiaomin, Luo, Qi, Mifune, Arias, Norheim, Frode, Piao, Meiling, Yee, Sook Wah, Zou, Ling   +14 more
core   +3 more sources

Scientific Opinion on the safety and efficacy of vitamin B1 (thiamine mononitrate and thiamine hydrochloride) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products

EFSA Journal, 2011
Thiamine mononitrate administered via feed and thiamine hydrochloride via water for drinking are safe for the target animals having a wide margin of safety.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. [PDF]

, 2016
ObjectivesThiamin deficiency is highly prevalent in patients with sepsis, but the mechanism by which sepsis induces thiamin deficiency is unknown. This study aimed to determine the influence of various severity of sepsis on carrier-mediated intestinal ...
Fang, Liwei, Said, Hamid M, Sassoon, Catherine S, Subramanian, Veedamali S, Zhu, Ercheng   +4 more
core   +2 more sources

Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis [PDF]

, 2015
Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be ...
Andrey, Vovk, Contestabile, Roberto, DI SALVO, Martino Luigi, Garik, Mkrtchyan, Lucien, Bettendorff, Parroni, Alessia, Thilo, Kaehne, Vasily, Aleshin, Victoria, Bunik, Yulia, Parkhomenko   +9 more
core   +1 more source

The Effect of Thiamine Concentration on the Antioxidative Activity Indices in Tea Extracts

Antioxidants, 2019
The aim of the study was to determine correlations between the concentration of thiamine in systems and indicators of the antioxidative activity of ethanol tea extracts in the presence of soybean oil.
Justyna Piechocka, Krystyna Szymandera-Buszka, Joanna Kobus-Cisowska, Anna Gramza-Michałowska, Anna Jędrusek-Golińska   +4 more
doaj   +1 more source

Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes [PDF]

, 2012
Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy.
A Adaikalakoteswari, A AntonySunil, A Makino, A Turano, Anindita Das, AO Phillips, B Ashokkumar, B Dutta, B Sihag, BR Chamberlain, CME Tallaksen, Daniel Zehnder, ED Schleicher, Fang Zhang, G Gastaldi, GLJ Page, Guerman Molostvov, H Lum, H Smithline, HM Said, I Hubatsch, J Rieck, James R. Larkin, JC Reidling, JC Reidling, JC Reidling, JD Eudy, KA Robinson, Lisa Godfrey, MJ Boulware, MJ Ryan, MW Pfaffl, N Rabbani, N Rabbani, N Takahashi, N Tasevska, Naila Rabbani, Paul J. Thornalley, PJ Thornalley, R Babaei-Jadidi, S Sander, SM Nabokina, VS Subramanian   +42 more
core   +2 more sources

Generation of Lamprey Monoclonal Antibodies (Lampribodies) Using the Phage Display System. [PDF]

, 2019
The variable lymphocyte receptors (VLRs) consist of leucine rich repeats (LRRs) and comprise the humoral antibodies produced by lampreys and hagfishes.
Amemiya, Chris T, Hansen, John D, Hassan, Khan MA, Herrin, Brantley R   +3 more
core   +2 more sources

Auto-adhesive transdermal drug delivery patches using beetle inspired micropillar structures [PDF]

, 2013
The patch described in this paper combines the principles of wet adhesion, which is a widely adopted biological adhesion system in nature, with transdermal drug delivery.
Prausnitz, Guy, Ball, Patel, Stork, Federle, Autumn, Jiao, Gorb, Autumn, Kesel, Bauchhenss, Walker, Gorb, Homann, Hiller, Federle, Autumn, Kwon, Mahdavi, Lee, Glass, Yanek, Lawrence, Malcolm, Saito, Stamatialis, Kajihara, Maeda, Kohnen, Homma, Woolfson, Valenta, Valenta, Park, Chen, Kuo, Persson, Peressadko, Spolenak, Petrisor, Barry, Sloan, Snorradottir, Vane, Goldstein, Kearney, Sift Carter   +47 more
core   +4 more sources

Re-emergence of thiamine deficiency disease in the Pacific islands (2014-15): A case-control study. [PDF]

PLoS ONE, 2018
BackgroundFrom late 2014 multiple atolls in Kiribati reported an unusual and sometimes fatal illness. We conducted an investigation to identify the etiology of the outbreak on the most severely affected atoll, Kuria, and identified thiamine deficiency ...
Eric J Nilles, Atarota Manaia, Bineta Ruaia, Clare Huppatz, Catherine Ward, Peter George, Christiaan Sies, Alessio Cangiano, James Sejvar, André Reiffer, Teatoa Tira   +10 more
doaj   +1 more source

Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population.

PLoS ONE, 2012
BackgroundThe provision of high doses of thiamine may prevent thiamine deficiency in the post-partum period of displaced persons.Methodology/principal findingsThe study aimed to evaluate a supplementation regimen of thiamine mononitrate (100 mg daily) at
Wolfgang Stuetz, Verena Ilona Carrara, Rose McGready, Sue Jean Lee, Hans Konrad Biesalski, François Henry Nosten   +5 more
doaj   +1 more source